DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Wwp2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	1094	Identity:	333/1094 - (30%)
Similarity:	464/1094 - (42%)	Gaps:	333/1094 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FAKVQVDG-------TGQVYSTEISKSSLDPKWNAHYDLFLGIGDAITITVWNQRKIHKGSGFLG 94
            :.:|.|||       ||:    .|..|.|  .||....|.:.....:.:.||:...:.  :..||
Mouse    41 YVEVAVDGLPSETKKTGK----RIGSSEL--LWNEIIVLNVTAQSHLDLKVWSCHTLR--NELLG 97

  Fly    95 CVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPS--SGNPLAIV--GPSGD 155
            ...:...|:  ||..|      ||:.       ..|:.::|.:::..|  ||..|.|.  ||:.|
Mouse    98 TASVNLSNV--LKNNG------GKME-------NTQLTLNLQTENKGSVVSGGELTIFLDGPTVD 147

  Fly   156 VRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHN 220
            :          .|:|.|                   |...|..:.|....|..|.:|:.||
Mouse   148 L----------GSVPNG-------------------SAVTDGSQPPSRESSGTAIAPETRH---- 179

  Fly   221 GNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTT 285
                  |.|     ||.|.     |.|||        ..|||         ..::.|...::..:
Mouse   180 ------QPP-----STNCF-----GGRSR--------THRHS---------GGSARTATAASEQS 211

  Fly   286 PGKKTSS----SNSSSAGGRTLEQRPTNEPATPTS-----------STTSASVRLHSNDNHVKTP 335
            ||.:...    .||||:|   |.....||..||.|           |..:|::.:.||.|...
Mouse   212 PGARNRHRQPVKNSSSSG---LANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTS-- 271

  Fly   336 KHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAA--QPQSASNGWTQEDAATTTSPS 398
                   .|.:|||           ...:..||||.....||  .|.:...||.|.:.
Mouse   272 -------LPAQSTP-----------AEGEEASTSGTQQLPAAAQAPDALPAGWEQREL------- 311

  Fly   399 TTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSR 463
                                      .||.|:..:.|             |..|..:|
Mouse   312 --------------------------PNGRVYYVDHN-------------TKTTTWER------- 330

  Fly   464 QQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQ 528
                                                              .||||:|.||..:|:
Mouse   331 --------------------------------------------------PLPPGWEKRTDPRGR 345

  Fly   529 VYFYHIPTGVSTWHDP--RIPRDFD------------TQHLTL-------------DAIGPLPSG 566
            .|:....|..:||..|  ...|:::            .||.:.             |.:||||.|
Mouse   346 FYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPG 410

  Fly   567 WEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPP------TSAA-------NAGTP 618
            ||:|:. :||||:|:||.||||:.|||..|    ||:...:||      ||..       |
Mouse   411 WEKRQD-NGRVYYVNHNTRTTQWEDPRTQG----MIQEPALPPGWEMKYTSEGVRYFVDHN---- 466

  Fly   619 APPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVG 683
                                         |.|||...|.   |....|..:|:.  ..|.|....
Mouse   467 -----------------------------TRTTTFKDPR---PGFESGTKQGSP--GAYDRSFRW 497

  Fly   684 KLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAR 748
            |....|. |........|.::.|||..:||:|::.||.|:..|:|:||.:..:|||||||||:||
Mouse   498 KYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561

  Fly   749 EWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGF 813
            ||..|||.|:|||.|.||:|:..::|.|||||.|.:|||||:||.|:||.:.:|::||..:|.||
Mouse   562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGF 626

  Fly   814 TTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGG 877
            |.||||::|||..||.|:|.:||:.:.|:.|:.|:|:... :|..|..:....|.:..||||.||
Mouse   627 TLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGG 691

  Fly   878 ASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSID 942
            .:|.||||||.||:.|..::||.||:|:|..|...||.|:.|...||.|||:||||::.|:..||
Mouse   692 ENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 756

  Fly   943 VNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGP 1007
            ::||:.|...:|.|..:.|:.||||||:...:|.|.||||||||:.|:|:.||..|.||.   ||
Mouse   757 MSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN---GP 818

  Fly  1008 RLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            :.|.|........  ||::||||||:|||||::|:.|.:||..|:|||.||..|
Mouse   819 QKFCIDRVGKETW--LPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	23/104 (22%)
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736	13/33 (39%)
		WW	562..594	CDD:197736	20/31 (65%)
		HECTc	702..1058	CDD:238033	174/356 (49%)
		HECTc	726..1058	CDD:214523	165/332 (50%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	29/123 (24%)
		PRK07003	<149..>299	CDD:235906	52/228 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		52/228 (23%)
		WW	302..331	CDD:366073	10/131 (8%)
		WW	332..361	CDD:366073	12/28 (43%)
		WW	407..435	CDD:366073	17/28 (61%)
		WW	447..477	CDD:238122	10/65 (15%)
		HECTc	516..868	CDD:238033	175/356 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750