DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Smurf2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	1059	Identity:	474/1059 - (44%)
Similarity:	582/1059 - (54%)	Gaps:	322/1059 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGI 72
            ||||..|:|:|:|||:||.:||.||||||||||.|||:||.:||:..|::||||||.||||::|.
Mouse     7 RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGK 71

  Fly    73 GDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISL 135
            .|::||:|||.:||||  |:|||||||:.:..|..||..|:|||||.||.|:|::.|||||::||
Mouse    72 SDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSL 136

  Fly   136 LSKDGPSSGNPLAIVGPSGDVRGPSEDDSS---EDSLPEGWEERRTDNGRVYYVNHATKSTQWDR 197
            .|:|.         :|..|.|     .|.|   ::.||:|||||||.:||:.|:||.|::|||:|
Mouse   137 QSRDR---------IGTGGQV-----VDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWER 187

  Fly   198 PRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHS 262
            |.:|
Mouse   188 PTRP------------------------------------------------------------- 191

  Fly   263 TEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHS 327
                   ..|.:||..|:|...                      ..|.|.|.|:..|..    ||
Mouse   192 -------ASEYSSPGRPLSCFV----------------------DENTPITGTNGATCG----HS 223

  Fly   328 NDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAA 392
            :|..:...:.::..|             :||::..
Mouse   224 SDPRLAERRVRSQRH-------------RNYMSRT------------------------------ 245

  Fly   393 TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRS 457
                         |..:||
Mouse   246 -------------HLHTPP---------------------------------------------- 251

  Fly   458 QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMR 522
                                                                    |||.|||.|
Mouse   252 --------------------------------------------------------DLPEGYEQR 260

  Fly   523 TTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTT 587
            |||||||||.|..||||||||||:|||.  .::..:.:||||.|||.|.||:|||||||||||||
Mouse   261 TTQQGQVYFLHTQTGVSTWHDPRVPRDL--SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTT 323

  Fly   588 QFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTT 652
            ||||||||.::..::.|.............|..|..|..                      ||
Mouse   324 QFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTEC----------------------LT-- 364

  Fly   653 TNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYR 717
                                 :|:|:||||.||:.||.||...|||:||||:||||.||||||||
Mouse   365 ---------------------VPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYR 408

  Fly   718 LIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDS 782
            .:||||.||:.||||:||:|||||||||||||||:|||.|||||.||||||||||.|||||||||
Mouse   409 QVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDS 473

  Fly   783 GVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLE 847
            .|||:||||||||||.:|:||||||.:|||||.|||||||.|.|||.|:|.||||||.||.|:||
Mouse   474 AVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE 538

  Fly   848 SNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQK 912
            ::|:|:::.||.||:|::|.::.|||||.|.|||||||||:|||:||||:||:||||.|||||||
Mouse   539 NDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQK 603

  Fly   913 GFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMR 977
            ||.|:||.|||:.|||:||||:|.|:..|||:||:.||||||||.::..|.|||:.||.:..|.|
Mouse   604 GFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERR 668

  Fly   978 ARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQ 1042
            ||||||||||||||||||:|||   ||.|||||||| ..|..|.|||||||||||||:||||:|:
Mouse   669 ARLLQFVTGSSRVPLQGFKALQ---GAAGPRLFTIH-QIDACTNNLPKAHTCFNRIDIPPYESYE 729

  Fly  1043 LLCDKLTQAVEETCGFAVE 1061
            .|.:||..|:|||||||||
Mouse   730 KLYEKLLTAIEETCGFAVE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	75/122 (61%)
		WW	169..198	CDD:278809	18/28 (64%)
		WW	514..546	CDD:197736	26/31 (84%)
		WW	562..594	CDD:197736	27/31 (87%)
		HECTc	702..1058	CDD:238033	257/355 (72%)
		HECTc	726..1058	CDD:214523	238/331 (72%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028	76/123 (62%)
		WW	159..188	CDD:278809	18/28 (64%)
		WW	252..283	CDD:197736	25/30 (83%)
		WW	298..330	CDD:197736	27/31 (87%)
		HECTc	393..745	CDD:238033	257/355 (72%)
		HECTc	420..745	CDD:214523	237/328 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836314
Domainoid	1	1.000	477	1.000	Domainoid score	I424
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41490
Inparanoid	1	1.050	705	1.000	Inparanoid score	I656
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46051
OrthoDB	1	1.010	-	-		D103319at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm43628
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X2041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800