Protein Alignment Smurf and SMURF2

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_073576.1
• Gene: SMURF2 / 64750
• HGNCID: 16809
• Length: 748
• Species: Homo sapiens
• Alignment Length: 1059
• Identity: 477/1059 - (45%)
• Similarity: 589/1059 - (55%)
• Gaps: 322/1059 - (30%)

  Fly     8 RRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGI 72
            ||||..|:|:|:|||:||.:||.||||||||||.|||:||.:||:..|::||||||.||||::|.
Human     7 RRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGK 71

  Fly    73 GDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISL 135
            .|::||:|||.:||||  |:|||||||:.:..|..||..|:|||||.||.|:|::.|||||::||
Human    72 SDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSL 136

  Fly   136 LSKDGPSSGNPLAIVGPSGDVRGPSEDDSS---EDSLPEGWEERRTDNGRVYYVNHATKSTQWDR 197
            .|:|.         :|..|.|     .|.|   ::.||:|||||||.:||:.|:||.|::|||:|
Human   137 QSRDR---------IGTGGQV-----VDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWER 187

  Fly   198 PRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHS 262
            |.:|                     :.:..:|..|
Human   188 PTRP---------------------ASEYSSPGRP------------------------------ 201

  Fly   263 TEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHS 327
               ||....||    ||:|.|          |.::.|                   .|:..||
Human   202 ---LSCFVDEN----TPISGT----------NGATCG-------------------QSSDPRL-- 228

  Fly   328 NDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAA 392
            .:..|::.:|                  :||::..
Human   229 AERRVRSQRH------------------RNYMSRT------------------------------ 245

  Fly   393 TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRS 457
                         |..:||
Human   246 -------------HLHTPP---------------------------------------------- 251

  Fly   458 QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMR 522
                                                                    |||.|||.|
Human   252 --------------------------------------------------------DLPEGYEQR 260

  Fly   523 TTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTT 587
            |||||||||.|..||||||||||:|||.  .::..:.:||||.|||.|.||:|||||||||||||
Human   261 TTQQGQVYFLHTQTGVSTWHDPRVPRDL--SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTT 323

  Fly   588 QFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTT 652
            ||||||||.::..::.|..                              |..........:|
Human   324 QFTDPRLSANLHLVLNRQN------------------------------QLKDQQQQQVVSL--- 355

  Fly   653 TNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYR 717
                   .||..:.|     .:|:|:||||.||:.||.||...|||:||||:||||.||||||||
Human   356 -------CPDDTECL-----TVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYR 408

  Fly   718 LIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDS 782
            .:||||.||:.||||:||:|||||||||||||||:|||.|||||.||||||||||.|||||||||
Human   409 QVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDS 473

  Fly   783 GVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLE 847
            .|||:||||||||||.:|:||||||.:|||||.|||||||.|.|||.|:|.||||||.||.|:||
Human   474 AVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE 538

  Fly   848 SNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQK 912
            ::|:|:::.||.||:|::|.::.|||||.|.||||.||||:|||:||||:||:||||.|||||||
Human   539 NDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQK 603

  Fly   913 GFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMR 977
            ||.|:||.|||:.|||:||||:|.|:..||||||:.||||||||.::..|.|||:.||.:..|.|
Human   604 GFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERR 668

  Fly   978 ARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQ 1042
            ||||||||||||||||||:|||   ||.|||||||| ..|..|.|||||||||||||:||||:|:
Human   669 ARLLQFVTGSSRVPLQGFKALQ---GAAGPRLFTIH-QIDACTNNLPKAHTCFNRIDIPPYESYE 729

  Fly  1043 LLCDKLTQAVEETCGFAVE 1061
            .|.:||..|:|||||||||
Human   730 KLYEKLLTAIEETCGFAVE 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	75/122 (61%)
		WW	169..198	CDD:278809	18/28 (64%)
		WW	514..546	CDD:197736	26/31 (84%)
		WW	562..594	CDD:197736	27/31 (87%)
		HECTc	702..1058	CDD:238033	257/355 (72%)
		HECTc	726..1058	CDD:214523	238/331 (72%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028	76/123 (62%)
		HUL4	<159..745	CDD:227354	384/888 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146214
Domainoid	1	1.000	475	1.000	Domainoid score	I442
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41490
Inparanoid	1	1.050	694	1.000	Inparanoid score	I686
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46051
OrthoDB	1	1.010	-	-		D103319at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm41581
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X2041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800