DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smurf and SMURF1

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_065162.1 Gene:SMURF1 / 57154 HGNCID:16807 Length:757 Species:Homo sapiens


Alignment Length:1087 Identity:458/1087 - (42%)
Similarity:566/1087 - (52%) Gaps:369/1087 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 RRNGTH-KVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLG 71
            ||||:. |:|:|:|||:|||:||.|||||||||:.|||:||.:||:..|::||||||.||||::|
Human     7 RRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVG 71

  Fly    72 IGDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIIS 134
            ..|:|||:|||.:||||  |:|||||||:.:..|..||..|:|||||.||:|.|.:.|||||::|
Human    72 KTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVS 136

  Fly   135 LLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPR 199
            |.::|...:|      |...|.||..|::                 |.||               
Human   137 LQTRDRIGTG------GSVVDCRGLLENE-----------------GTVY--------------- 163

  Fly   200 QPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTE 264
                                                                             
Human   164 ----------------------------------------------------------------- 163

  Fly   265 ILSSVGKENTSPTTPVSA-TTTPGKKTSSSNSSSAGG--RTLEQRPTNEPATPTSSTTSASVRLH 326
                   |::.|..|:|. ...|...|.|:.:::.||  |.:|        :|:......:.||.
Human   164 -------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVE--------SPSQDQRLQAQRLR 213

  Fly   327 SND--NHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQE 389
            :.|  ..::||:::.:||..||                                           
Human   214 NPDVRGSLQTPQNRPHGHQSPE------------------------------------------- 235

  Fly   390 DAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPG 454
                                                                             
Human   236 ----------------------------------------------------------------- 235

  Fly   455 QRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGY 519
                                                                        ||.||
Human   236 ------------------------------------------------------------LPEGY 240

  Fly   520 EMRTTQQGQVYFYHIPTGVSTWHDPRIPR--------------DF----------DTQHLTLDAI 560
            |.|||.||||||.|..||||||||||||.              :|          |...:..|.:
Human   241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDEL 305

  Fly   561 GPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATP 625
            ||||.|||.|.|.|||:|||||||||||||||||...:           ........|:.|...|
Human   306 GPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIM-----------NHQCQLKEPSQPLPLP 359

  Fly   626 ATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADL-LPKYRRDLVGKLRALR 689
            :                                      :|.||..:| ..:|.||||.||:.||
Human   360 S--------------------------------------EGSLEDEELPAQRYERDLVQKLKVLR 386

  Fly   690 TELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLL 754
            .||...|||:||||:||||.||||||||.|||||.||::|||||||:|||||||||||||||:||
Human   387 HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLL 451

  Fly   755 SREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYK 819
            ..|||||.|||||||.|:.|.|||||||.:|||||||||||||.:|:||||||.::||||.||||
Human   452 CHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYK 516

  Fly   820 QLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTE 884
            |||.|||.|.|:|.|||:||:||.|:||::|:.:::.||.||:|:||.::.|||||.|.::||||
Human   517 QLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTE 581

  Fly   885 ENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNN 949
            |||:|||:||||:|||||||.|||||||||.||||.|||:|||::||||:|||:..||:|||::|
Human   582 ENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSN 646

  Fly   950 TRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHL 1014
            ||||||..::..|.||||.||::..|.|||||||||||:|||||||:||||||||.|||||||||
Human   647 TRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL 711

  Fly  1015 TADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
             .|..|.|||||||||||||:||||:|:.|.:||..|||||||||||
Human   712 -IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 76/122 (62%)
WW 169..198 CDD:278809 3/28 (11%)
WW 514..546 CDD:197736 24/31 (77%)
WW 562..594 CDD:197736 26/31 (84%)
HECTc 702..1058 CDD:238033 258/355 (73%)
HECTc 726..1058 CDD:214523 238/331 (72%)
SMURF1NP_065162.1 C2_Smurf-like 14..138 CDD:176028 77/123 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..237 13/219 (6%)
WW 236..267 CDD:197736 24/30 (80%)
WW 307..339 CDD:197736 26/31 (84%)
HECTc 399..754 CDD:238033 258/355 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 475 1.000 Domainoid score I442
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 694 1.000 Inparanoid score I686
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46051
OrthoDB 1 1.010 - - D103319at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm41581
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - LDO PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X2041
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

Return to query results.
Submit another query.