DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and plekha7a

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	738	Identity:	141/738 - (19%)
Similarity:	226/738 - (30%)	Gaps:	261/738 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVG 205
            |.:|.|:    .||.:        ....||.||||..|..|..::::|..::|.:..|    |.|
Zfish    39 PRTGQPV----NSGHM--------IRSDLPSGWEEGFTKEGASFFIDHNQRTTTFIHP----VTG 87

  Fly   206 SSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVG 270
                     :.:|.|.:...:..|.|                            |...:..|::.
Zfish    88 ---------QISTENSDFRLQDQPGG----------------------------RMLKQPSSTIS 115

  Fly   271 KENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPT------SSTTSASVRLHSND 329
            :.:|:.||....:|:..|.:.||....:.|:. :......|:.|.      ....|:.:||....
Zfish   116 EASTTVTTSTVDSTSGSKGSRSSGRVHSFGKR-DHAIKRNPSXPVVVRGWLYKQDSSGMRLWKRK 179

  Fly   330 NHV----------KTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQ-----AAQP 379
            ..|          .:.:....|..|..|...:|.|.::::   ::..:.....:|.     :|..
Zfish   180 WFVLADFCLFYYKDSREESVLGSIPLPSYTIAPVGPEDHI---SRKYAFKAEHTGMRTYYFSADT 241

  Fly   380 QSASNGWTQ--EDAA---TTTSPSTTTSPPRH--------------------------------- 406
            |...|||.:  ..||   |.|........|.|
Zfish   242 QEDMNGWVRAMNQAALMQTHTVKRDECGHPDHVNVSEKLKKQAVPQTNHINSYVIPKPEVIQSDG 306

  Fly   407 --------------------------SQSPPT---------PNISPPASVTPSANGN-VHSP--- 432
                                      .:||.:         |..:||:.|...|... |.:|
Zfish   307 LPEDKREGFVGEVEIQVTPREMEQARGKSPASRVVEVEVLAPGSTPPSRVASRAPSRAVSTPPVV 371

  Fly   433 NANSTPAGSGGGSRSYTAATPGQRS----QRRSSRQQGE----------------ESSTRRRSSR 477
            ..|.||....|.......|||..::    ||||:.:|.|                ||:..||:..
Zfish   372 QRNGTPIEQNGMPGCQRGATPSAQTPVQVQRRSTLEQVENWVKVQKEERHGLVSTESTVPRRTPP 436

  Fly   478 GTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWH 542
            .....||.         .:|.|....:......|...||..|:....:.......|..|...|.|
Zfish   437 IHPKYGTM---------DKYQSLPKTSRQSPPAPHHQLPSEYKYSHDRLNHFQKIHGHTKRPTTH 492

  Fly   543 DPRIPRDFDTQHLTLDAIGPLPSGWEQRK-----TASGRVY--FVDHNNRTTQF-TDPRLSGSIL 599
            |..:.:.|:               |:||:     :....||  ..|::...:.. .:|.:|.|:
Zfish   493 DNTVWQLFE---------------WQQRQQFRHGSPFAPVYTPAPDYSTAVSSTRNNPDVSRSV- 541

  Fly   600 QMIRRGTVPPTSAANAGTPAPPSA------TPATPSAAAAVPP-QATPASNATPTTLTTTTNPPH 657
                  :|||| .|:...|.||.|      .|.||:....|.| :..|.....|      :|.||
Zfish   542 ------SVPPT-LADIPPPGPPGARLMSPRRPHTPAERVTVRPLEDRPIVEVPP------SNSPH 593

  Fly   658 RIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVS----RNEIFEESYRL 718
            |               |..|:...:        |.::| |.|.:....||    |.:..:::|
Zfish   594 R---------------LRSYKSATI--------ERRSM-PPSAYITHTVSAPSLRGKTADDTY-- 632

  Fly   719 IMKMRAKDMRKRLMVKFKGEEGL 741
               |..|...:.|.:|..|.|.|
Zfish   633 ---MHLKKGLEYLDLKVSGTEAL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	10/28 (36%)
		WW	514..546	CDD:197736	8/31 (26%)
		WW	562..594	CDD:197736	7/39 (18%)
		HECTc	702..1058	CDD:238033	11/44 (25%)
		HECTc	726..1058	CDD:214523	5/16 (31%)
plekha7a	NP_001129715.1	WW	55..84	CDD:278809	10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148		12/78 (15%)
		PH_PEPP1_2_3	153..256	CDD:270068	17/105 (16%)
		PH	159..255	CDD:278594	15/98 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384		11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577		19/76 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900