DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and wwtr1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001032785.1	Gene:	wwtr1 / 568008	ZFINID:	ZDB-GENE-051101-1	Length:	391	Species:	Danio rerio

Alignment Length:	287	Identity:	64/287 - (22%)
Similarity:	96/287 - (33%)	Gaps:	86/287 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SSGNPLAIVGPSGDVRGPSE------------DDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQ 194
            |..:|.::..|:|.|.|||.            |.:.|..||.|||...|.||:.|::||..|.|.
Zfish    77 SRSSPASLQLPAGSVSGPSPGRLHSHTRHQSCDVAEELPLPPGWEMAFTPNGQKYFLNHIEKITT 141

  Fly   195 WDRPR------------------------------QPGVVGSSHATSPQQRHNTHNGNSGDRQAP 229
            |..||                              ||.:|.:..|...||:|..........|.|
Zfish   142 WHDPRKSMTPSVAQLSLHNQVSNTASIQQRSMALSQPNLVLNQQAHQQQQQHLQQQQQQVPVQVP 206

  Fly   230 AGPTRSTTCTNLMN-----NGHRSRDLSVTASDER--RHSTEILSS--------VGKENTSPTTP 279
            ....:..:...:||     :..:.|...:....||  |...|::..        :..:|..|..|
Zfish   207 VQAPQQQSSQPMMNLSAQQHQQKMRLQRIQMERERIQRRQEELMRQEVALRQLPMDSDNLPPVAP 271

  Fly   280 VSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAP 344
                      ...|.:.|||     ..|.|          ||...|:|...|.:.....:.....
Zfish   272 ----------AIGSPAMSAG-----NMPNN----------SADPFLNSGPYHSREQSTDSGLGLG 311

  Fly   345 PESTPTSPTGQQNYVNGNAQNGSTSGN 371
            ..|.||:|   ::::| |.::..|..|
Zfish   312 CYSIPTTP---EDFLN-NMEDMDTGEN 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	14/28 (50%)
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
wwtr1	NP_001032785.1	WW	115..146	CDD:197736	14/30 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810