DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and wwc3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	311	Identity:	74/311 - (23%)
Similarity:	115/311 - (36%)	Gaps:	62/311 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 LDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTL-DAIG-PLPSGWEQRKTASG 575
            |.||||:|......|:|::....|..::|.|   |||..|:.||. |.:| .||.|||.......
Zfish    15 LPLPPGWEEARDYDGRVFYIDHNTRQTSWID---PRDRITKPLTFADCVGDELPLGWEVVYDQQV 76

  Fly   576 RVYFVDHNNRTTQFTDPRLSGSILQ--MIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQA 638
            .||::||.|:|||..:||......|  |::...|....|.||            ......:..|.
Zfish    77 GVYYIDHINKTTQIENPRTQWRQEQERMLKEYLVVAQEALNA------------KKEMYQIKQQR 129

  Fly   639 TPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKY-------RRDLVGKLR----ALRTEL 692
            ...:..........|...:|.:.....|....|...|..       ||:.:.:|:    .:|.||
Zfish   130 LELAQQEMQLFNQLTQDDNRSITSSHSGSSSNAKYDPDQIKAEIACRRERLSRLKQELAQMRQEL 194

  Fly   693 Q-------TMQPQSGHCRLEVSR-------NEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDY 743
            |       |:|        |:.|       |...:|:..:..::|:  ::|.:....|..:.| .
Zfish   195 QYKEMGVETLQ--------EIDRKMSSSQTNYKLDEAQAIFSELRS--IKKAISTGEKERQDL-I 248

  Fly   744 GGVAREWLHLLS--REMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYF 792
            ..:|:..|:...  .|:.|....|........||     |:|...|.:..|
Zfish   249 QSLAKLTLNFCDSINEVTNNAESLADSCSVQQYT-----DAGCQTDLMGEF 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	10/31 (32%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033	19/100 (19%)
		HECTc	726..1058	CDD:214523	14/69 (20%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809	10/31 (32%)
		WW	64..93	CDD:278809	13/28 (46%)
		C2_Kibra	677..800	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810