DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and hecw1b

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_021336549.1	Gene:	hecw1b / 563730	ZFINID:	ZDB-GENE-060503-2	Length:	1555	Species:	Danio rerio

Alignment Length:	1421	Identity:	363/1421 - (25%)
Similarity:	539/1421 - (37%)	Gaps:	431/1421 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DYPRRNGTHKV---RITILCARNLARKDLFRLPDPFAKVQV-----------DGTGQVYSTEISK 55
            |.|:..|..::   .::...|..| :|.:|..|||:.|:.:           ...||...:.|..
Zfish   202 DVPQSQGRRRLISFSLSDFQATGL-KKGMFFNPDPYLKIAIHPGKHSIFPALPHHGQEKRSGIVC 265

  Fly    56 SSLDPKWNAHYDLFLGI-GDAITITVWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD 115
            ::::|.|......|:.: .|.:.|.|.::    |.|.|  .|||.:.:|...:......|.:.:.
Zfish   266 NTINPVWQRERFNFVSLPTDVLEIEVKDKFAKSRPIIK--RFLGKLSMPVQRLLEKHAIGDRVVS 328

  Fly   116 --LGKLSPDDDELVRGQI-----IISLLSKDGP----SSGNPLAIVGPSGDVRGPSEDDSSEDSL 169
              ||:..|  .|.|.||:     |.|.:..|..    |:..|:|.......   |..:|:.  ||
Zfish   329 YTLGRRLP--TEHVSGQLQFRFEITSSIHPDDEDMSLSTEQPVAAAEAQAQ---PQAEDTM--SL 386

  Fly   170 PEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPA---- 230
            ..|..|...|..        |.|.:.....:.|...::.|...::.........|:..|.|
Zfish   387 DLGAPELPLDGD--------TASVEMPMDVESGQSCAAEADVIEEECLEEEQQEGEAAAAAAAME 443

  Fly   231 -GPTRSTTCTNLMN--NGHRSRD------LSVTASDERRHSTEILSSVGKENTSPTTPVSAT--- 283
             ..|.:...|.:::  ||....:      .:..:||.|         .|:|:.:.:.|..|:
Zfish   444 QSETNAEETTQVLDPINGAEEEEAENNCAFAEESSDAR---------AGEEDEAISDPQPASEEP 499

  Fly   284 -------------TTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTP 335
                         |||.:|....:...:...|:......||.||.|.    .:|:|...:.:...
Zfish   500 DADLEEDCSLRIRTTPRRKPRPCSLPVSELETVIASACGEPETPRSH----YIRIHHLLHSLPAT 560

  Fly   336 KHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTT 400
            :.||...|.||  |..|.|.:.                   ...:....|.|.||.|.|.:....
Zfish   561 QPQTGDSAGPE--PDRPMGVEE-------------------EDEEEEEEGVTLEDHALTPNGPRR 604

  Fly   401 TSPPRHSQ------------------------SPPTPNISPPA---SVTPSANGNVHSPNANSTP 438
            |.|...|.                        :..:|::||.|   .::|.|:|.:.:.:.:|
Zfish   605 TLPRSRSHERLSDLIQMLDGDGHPLGAEGQTGNQRSPDLSPVACCSHMSPRASGPIRAQSLDS-- 667

  Fly   439 AGSGGGSRSYTAATPGQRSQRRSSRQQG--------EESSTRRRSSRG-------------TRNG 482
                 ..||.:.....|..:....:..|        |:.:..|....|             :.:|
Zfish   668 -----ARRSESTVFSSQDDEDEMEQPNGILGSETETEQGAQCREPGDGSCQWEEAPDSHVQSPHG 727

  Fly   483 GTSGGGGGGGSGQRYASAAI--AAANQ--AAR------PFLD--LPPGYEMRTTQQGQVYFYHIP 535
            ....|...|.||:|......  .|.:|  |.|      |.:|  |||.:|.|....|:|::....
Zfish   728 IVGNGEVAGPSGRRECPLPCNHPAVSQLPALRPDPHHYPTIDEPLPPNWEARIDSHGRVFYVDHI 792

  Fly   536 TGVSTWHDP-------------------RIPRDFDT----------------------------- 552
            ...:||..|                   ::.|.:.|
Zfish   793 NRTTTWQRPTSAATPDGLRRSGSVQQMEQLNRRYQTIQRTMATERREEESGSPRNDRTANTETDS 857

  Fly   553 ----------------------------------------------------------QHLTL-- 557
                                                                      :|:.|
Zfish   858 PLQTNELRRDTSCSPGHCQKITLLLQSPAVKFITHPEFFTVLHANYGAYRMFTNSSCLKHMVLKI 922

  Fly   558 ------------------------DAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRL---S 595
                                    ||...||.|||.:....|:.:|||||:|.|.|.|||:   :
Zfish   923 RRDARNFERYQHNRDLVTFLNRFADAQLELPRGWEIKTDPQGKSFFVDHNSRATTFIDPRIPLQN 987

  Fly   596 GSI---------LQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAV--PPQATPASNATPTTL 649
            |.:         ||.:|..:....|..:........|.|.. |..||:  ..|..|...|....:
Zfish   988 GRLPNHLTHRQHLQRLRSYSAGEASEVSRTRGVSLLARPGN-SLVAAIRNQSQQEPVPLAYNDKI 1051

  Fly   650 TTTTNPP-----------------------HRI-------------------------------V 660
            ......|                       |.|                               |
Zfish  1052 VAFLRQPNIFEVLQERQPSFARNHSLKDKVHHIRTEGTQRLEKLSCDADLVMLLSLFEEDIMSYV 1116

  Fly   661 P-----------------DLPQ---GLLEGADLLP-------------------KYRRDLVGKLR 686
            |                 ..||   |.||...|:|                   .||||...|||
Zfish  1117 PLASFHPGFNFSPRCSPGSSPQNSPGFLERTPLVPACCLSGESSPGTQRARAPAPYRRDFEAKLR 1181

  Fly   687 ALRTELQT----MQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGV 746
            ....:|:.    ..|  |..:|.|.|:.:.|.::..:|....|:: |.:|.:.|.|||||||.|.
Zfish  1182 NFYRKLEAKGYGQGP--GKIKLIVRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGP 1244

  Fly   747 AREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDG 811
            :||:..|||:|:.||.||||:||.:|.||:||:|.|....:||.:|.|.||.||:|:.|.:.||.
Zfish  1245 SREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDA 1309

  Fly   812 GFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPG 876
            .||.||||.||..|..|.|:|.:|.:.|:||.||.|::|:.:::.||:|....||.:...|||.|
Zfish  1310 FFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKENDITDVLDLTFTVNEEVFGQVTERELKSG 1374

  Fly   877 GASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSI 941
            |.::.|||:||:||::..|.:|..||:.||..||.:||.|::.|.|:..||.|||||||.|.:.|
Zfish  1375 GTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTAEI 1439

  Fly   942 DVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
            |:|||||||..:...::...|: |||..||.:::|.|.||||||||:|.||.:||.||:||.|.
Zfish  1440 DLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSSVPYEGFTALRGSNGL- 1503

  Fly  1006 GPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
              |.|.|.....:  .:||:|||||||:|||||.:|.:|.:||..|||||..|.:|
Zfish  1504 --RRFCIEKWGKI--TSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE 1555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	33/146 (23%)
		WW	169..198	CDD:278809	6/28 (21%)
		WW	514..546	CDD:197736	11/52 (21%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	171/357 (48%)
		HECTc	726..1058	CDD:214523	165/333 (50%)
hecw1b	XP_021336549.1	HECW_N	73..192	CDD:318711
		C2_NEDL1-like	213..349	CDD:176073	32/140 (23%)
		WW	771..803	CDD:197736	10/31 (32%)
		WW	952..983	CDD:197736	16/30 (53%)
		HECTc	1223..1552	CDD:214523	165/333 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810