Protein Alignment Smurf and hectd2

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_009304826.1
• Gene: hectd2 / 562999
• ZFINID: ZDB-GENE-100405-3
• Length: 756
• Species: Danio rerio
• Alignment Length: 623
• Identity: 170/623 - (27%)
• Similarity: 261/623 - (41%)
• Gaps: 135/623 - (21%)

  Fly   538 VSTWHDPRIPRDFDTQHLTLDA-IGPLPSGWEQRKTASG-RVYFVDHNNRTTQFTDPRLSGSILQ 600
            |:..:|..:....|||...|.. |..|...|:..:|... |.|||...|  .|:|.|........
Zfish   170 VNIVYDALLHTPADTQKSVLKGIINSLLREWKGPRTKDDLRAYFVLVQN--PQYTSPATYVIYAH 232

  Fly   601 MIRRGTVPPTSAANAGT---------------------------------PAPPSATPATPSAAA 632
            ::|:      .||.|..                                 ||.|...|.....:.
Zfish   233 LLRQ------IAALAEADHHFLMHWFKKLPQKRFKQLVERLQLFITTRLFPAKPEELPPMAKCSW 291

  Fly   633 AVPPQATPASNATPTTLTTTTNPPHRIVP--DLPQGLLEGADLLPKY------------------ 677
            .: |.||...:......:.::.|   |:|  |.....|:..|.:..|
Zfish   292 WI-PSATKVLSLLNAANSISSAP---IIPFTDFYNLTLDHIDFMEDYHTWQVHGNSNRFTFCQFP 352

  Fly   678 ------------------------RRDLVGKL-RALRTELQTMQPQSGHCRLEVSRNEIFEESYR 717
                                    |:.||.|: |..|.::..:     ...::|.|.::..:|..
Zfish   353 FILSTVVKKAIIQRDSEQQMISMARQTLVDKVSRRQRVDMSLL-----FLNIKVRRLQLVSDSLD 412

  Fly   718 LIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDS 782
            .:.:.|| |::|:|.|.|.||.|||.||:.:||..||.|::.:..||:|.|.::.    |....|
Zfish   413 ELSRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMFTYVKES----QCYWFS 472

  Fly   783 GVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPI--------------TLGDIEG 833
            ....|:.|.|..||..:|:||::...||..|....||:||..||              ||.|::.
Zfish   473 SWKCDNYSEFRLVGALMGLAVYNSITLDIRFPPCVYKKLLTPPIVPCDLDTPVGMATLTLDDLQQ 537

  Fly   834 VDPDLHRSLTWML--ESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVN 896
            :.|||...|..:|  |.|:.....:||.|.....|.:..:.|||||..||||..|::|||:||::
Zfish   538 IMPDLAHGLGELLSYEGNVEEDFYTTFQVFQEELGVVKAYNLKPGGDKIPVTNLNRKEYVQLYID 602

  Fly   897 YRFMRGIEQQFLALQKGFCELIPSH---LLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNE 958
            :...:.|.:||.|...||..:..|:   ||||   .|:|:::.|..::|:...:...:.:..:..
Zfish   603 FLLNKSIYRQFAAFYHGFHSVCASNALMLLRP---EEVEILVCGSPNLDMGSLQRVVQYEGYSKT 664

  Fly   959 TTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNL 1023
            ...:..||.||.::..|::.:||.|.|||.|||:.|...|......:           ||.|..|
Zfish   665 DPTIRAFWDVVLAFPLELQKKLLHFTTGSDRVPVGGMADLNFKISKI-----------DVSTDWL 718

  Fly  1024 PKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            |.:|||||:|.||||::.:.|..|||.|:....||.:|
Zfish   719 PVSHTCFNQICLPPYKSKKELRQKLTIAISNAEGFGLE 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	2/7 (29%)
		WW	562..594	CDD:197736	11/32 (34%)
		HECTc	702..1058	CDD:238033	125/374 (33%)
		HECTc	726..1058	CDD:214523	120/350 (34%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	126/375 (34%)
		HECTc	420..753	CDD:214523	120/350 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810