DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and nedd4l

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	1165	Identity:	364/1165 - (31%)
Similarity:	523/1165 - (44%)	Gaps:	266/1165 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YPRRNGTHKVRITILCARNL----ARKDLFRLPD---PFAKVQVD-------GTGQVYSTEISKS 56
            |||      :|:....::.|    |...|..:|:   |.::::.:       ..|..:.....::
Zfish   265 YPR------IRLERSTSQPLQPRGAPSRLGSMPNLHAPISEMETESDFIENGAQGCTFKIRKEQN 323

  Fly    57 SLDPKWNAHY----------DLFLGIGDAIT-------ITVWNQRKIHKGSG-----FLGCVRIP 99
            |..||:..::          :..:.||.|.|       |.:...:..|..:|     |||.|.:|
Zfish   324 SQQPKFKIYFSQGGEHSPILERNISIGKAPTCSNPQAHIGLDRPKNGHFNNGQTRDDFLGQVDVP 388

  Fly   100 AFNIQSLKGAGFQRLDLGK---LSP-DDDELVRGQIIISL--LSKDGPSSGNPLAIVGPSGDVRG 158
            ..::.: :....:|....|   |.| .....|:|.:.:.:  |.|:|.....       ||::|.
Zfish   389 LTHLPT-EDPAMERPYTFKDFLLRPRSHKSRVKGYLRLKMAYLPKNGGHEEE-------SGEMRE 445

  Fly   159 PSEDDSSEDS--------------LPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHA 209
            .:|.....||              ||.||||:..:.||.|||||..::|||.||....||.
Zfish   446 EAEGWEVTDSTDPGSQRPQQLLPPLPPGWEEKVDNLGRTYYVNHNNRTTQWKRPSSVDVVS---- 506

  Fly   210 TSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVG---K 271
                   .|.|.|.              ...:....||       ....|||.:|.|.:..   :
Zfish   507 -------ETENDNQ--------------LRQINQEAHR-------VFRSRRHISEDLENEQLDIR 543

  Fly   272 ENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSST----TSASVRLHSNDNHV 332
            :......|:| ...|...|...|.|.:|..:|        |.|.|||    ...|:||
Zfish   544 DIDDSWEPIS-EEDPTLLTDGLNHSLSGPSSL--------AMPLSSTPDFSDEISLRL------- 592

  Fly   333 KTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSP 397
             :....|||..|..|:..     |::::...::.|.:...|.||..|....:..|:...|.|.:.
Zfish   593 -SLAPDTNGEIPGPSSAV-----QSHLSSRLRSSSMTDGVSDQAQPPTPTQSSQTRRTRAQTVTG 651

  Fly   398 STTTSPPRHSQSPPTPNISP-------PASVTPSANGN------------VHSPNANSTPAGSGG 443
            ...|..|..|.:..||.:.|       |...|...|.|            .|:.:..||...:.|
Zfish   652 VEDTMSPSASYALTTPGLPPGWEERKDPKGRTYYVNHNNRSTTWTRPILQQHTEDGASTSVAAVG 716

  Fly   444 GSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRG---TRNGGTSGGG------------GGGGS 493
            |:   |||||...:...||....|....|.||...   |.:....|..            ....|
Zfish   717 GA---TAATPPASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPLEGANNVPIRRAVKDTFSNPQS 778

  Fly   494 GQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRI--PRDFDTQHLT 556
            .|....::....::|.:.|  ||||:|||....|:.:|....:..:||.|||:  |....|: .:
Zfish   779 PQPSPYSSPKTQHKANQSF--LPPGWEMRIAPNGRPFFIDHNSRTTTWEDPRLKYPVHMRTK-AS 840

  Fly   557 LDA--IGPLPS-----GWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAAN 614
            ||.  :||||:     |||:|..|.||.:::||||:.||:.||||.
Zfish   841 LDPGDLGPLPNLPEEPGWEERVHADGRTFYIDHNNKKTQWEDPRLQ------------------- 886

  Fly   615 AGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRR 679
                :|....||.|                                                |.|
Zfish   887 ----SPAITGPAVP------------------------------------------------YSR 899

  Fly   680 DLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKD-MRKRLMVKFKGEEGLDY 743
            :...|....|.:|:..........:::.||.|||||||.||.::..| ::.||.::|:.|:||||
Zfish   900 EFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESEKGLDY 964

  Fly   744 GGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGV-NPDHLSYFHFVGRTLGIAVFHGH 807
            |||||||..|||:||.||.||||:||..|:|||||||:||: |.||||||.|:||..|:||:||.
Zfish   965 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGK 1029

  Fly   808 CLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHE 872
            .|||.|..||||.:|.|.|||.|:|.||.:.:.||.|:||::.:. ::..|.::.::||.....:
Zfish  1030 LLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLRFCIDEDNFGQTYQVD 1093

  Fly   873 LKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGG 937
            |||.|:.:.||.:||:||:.|.:.:||:..:::|..|..:||.||||..|::.|||.||||::.|
Zfish  1094 LKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCG 1158

  Fly   938 ISSIDVNDWRNNTRLK--HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQG 1000
            :..:||||||.:|..|  :|.|... :.|||:.|....:|.|.||||||||:||||:.||..|.|
Zfish  1159 LGDVDVNDWRQHTVYKNGYCPNHPV-IQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG 1222

  Fly  1001 STGAVGPRLFTIHL--TADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            |.   ||:||||..  |.|    .||:|||||||:|||.|||::.|.:||..|||...||
Zfish  1223 SN---GPQLFTIEQWGTPD----KLPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGF 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	28/160 (18%)
		WW	169..198	CDD:278809	16/28 (57%)
		WW	514..546	CDD:197736	13/31 (42%)
		WW	562..594	CDD:197736	18/36 (50%)
		HECTc	702..1058	CDD:238033	182/361 (50%)
		HECTc	726..1058	CDD:214523	171/337 (51%)
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325	12/56 (21%)
		WW	473..499	CDD:306827	14/25 (56%)
		WW	669..698	CDD:306827	5/28 (18%)
		WW	798..829	CDD:197736	13/30 (43%)
		WW	856..885	CDD:238122	15/28 (54%)
		HECTc	946..1275	CDD:214523	171/337 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840