DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and LOC556872

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_021334149.1	Gene:	LOC556872 / 556872	-ID:	-	Length:	1472	Species:	Danio rerio

Alignment Length:	736	Identity:	147/736 - (19%)
Similarity:	241/736 - (32%)	Gaps:	218/736 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 AGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGW 173
            ||...:.:...||.....:||              ||..|:....|..||.....|      |.|
Zfish   243 AGASSVPVHTSSPSQSRNLRG--------------GNTSALENGLGPRRGARVRGS------ENW 287

  Fly   174 EERRTDNGRVYYVNHATK--STQW--------DRPRQPGVVGSSHA------------------- 209
            |...:|:|..||.:|..|  |:.|        |....|..:  ||:
Zfish   288 EMMYSDSGNAYYKDHHLKPSSSSWLNRRAHSRDNVCMPEYI--SHSCIWQSLTDLQSQCVQVAEF 350

  Fly   210 ---TSPQQRHNTHN--------------GNSGDRQ-------APAGPTRSTTCTNL--MNN---- 244
               .|..:..:.|.              |.|..|:       .|.||:...|...|  :|:
Zfish   351 TDQPSELRGFSVHTRLVKGARGFGFNIVGGSRRREFLQIYSITPGGPSTLNTADILVYINDTCVL 415

  Fly   245 GHRSRD-LSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPT 308
            |:..:| :.:..:....|:.:|:...|......:......:.| :.|:|.|          |.|.
Zfish   416 GYSHKDVVEMLKAIPIGHTVDIMVRRGYPMLYNSEGCPKMSNP-RLTASQN----------QSPH 469

  Fly   309 NEPATPTSSTTSASV---RLHSNDN---------------HVKTPKH--QTNGHAPPESTPTSPT 353
            ..|.|.|.....|.:   :||.|.|               .|:..:.  ..||::||.::|..|.
Zfish   470 LPPPTTTQPQAQAPLPYAQLHLNHNSPPWADFDRGSSRNLRVRASRFSLDANGNSPPFASPPRPP 534

  Fly   354 GQQNYVNGNAQNGSTSGNGSGQAAQPQSA--------SNGWTQEDAATTT--------------S 396
                    ::..|| :|.|||....|::|        :...:|.|:...:              :
Zfish   535 --------SSYQGS-NGYGSGFLRPPRTARSIRRLQSAELASQSDSEVVSAIGSHRASFIRNHNN 590

  Fly   397 PSTTTSPP------RHSQSPPTPNISPPASVTPSANGNVHSPNANSTP---AGSGGGSRSYTAAT 452
            .|.:|.||      :.|:|..:.:..||.|..|       .|:...:|   :.|.||.|.|:...
Zfish   591 NSLSTPPPLRLHSFKSSESDLSSSTPPPISRLP-------LPHTELSPGPVSFSPGGGRRYSHLR 648

  Fly   453 PGQRS-----------------QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASA 500
            ..|.|                 ...:|...|..:|:  ..|.|..:.....|.||..:|......
Zfish   649 KPQNSMLTPPSSVHSDGPYFTFNGTASASSGSPNSS--IPSPGALSAVIGSGVGGMAAGGELVPV 711

  Fly   501 AIAAANQAAR-PFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLP 564
            |:|...:.:. .|.....|:..|.|...:|:.:....|:.:..........|.|.|:...:..:
Zfish   712 ALAKCERGSNMGFSVTAGGHGGRQTLVKKVWDHRQCNGLQSGDAVVKINGADVQSLSFAQVQRI- 775

  Fly   565 SGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGT-VPPTSAANAGTP-------APP 621
               .|..|..|.|..:.:...:.....|       ..:||.| .||.||:::..|       :..
Zfish   776 ---LQEHTKKGEVILLVYRGPSNYSNSP-------SSVRRLTPPPPRSASDSEVPFTDSMPLSRN 830

  Fly   622 SATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGAD----LLPKYR---R 679
            |.||.:|:...:...|:|...::.|.|||..           |:..:...|    |.|:.:   :
Zfish   831 SLTPPSPALVRSSLVQSTSFLDSVPVTLTLE-----------PRDWMSSEDGGTVLSPRVKTEEK 884

  Fly   680 DLVGKLRALRTELQTMQPQSG 700
            :....||....||: .:|..|
Zfish   885 EQPPALRGYEVELK-RKPGEG 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	6/25 (24%)
		WW	169..198	CDD:278809	12/38 (32%)
		WW	514..546	CDD:197736	5/31 (16%)
		WW	562..594	CDD:197736	5/31 (16%)
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
LOC556872	XP_021334149.1	PDZ_signaling	24..88	CDD:238492
		NK	111..>190	CDD:327404
		PDZ_signaling	365..440	CDD:238492	13/74 (18%)
		PDZ	722..791	CDD:238080	13/72 (18%)
		PDZ_signaling	893..980	CDD:238492	4/13 (31%)
		PDZ_signaling	1017..1093	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900