Protein Alignment Smurf and Wwc2

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_598552.2
• Gene: Wwc2 / 52357
• MGIID: 1261872
• Length: 1187
• Species: Mus musculus
• Alignment Length: 553
• Identity: 121/553 - (21%)
• Similarity: 192/553 - (34%)
• Gaps: 144/553 - (26%)

  Fly   492 GSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLT 556
            ||||                 |.||.|:|......|:|::....|..::|.|   |||..|:.|:
Mouse     6 GSGQ-----------------LPLPRGWEEARDYDGKVFYIDHNTRRTSWID---PRDRLTKPLS 50

  Fly   557 L-DAIG-PLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLS--GSILQMIRRGTVPPTSAANAGT 617
            . |.:| .||.|||.........|::||.|:|||..|||..  |...:|::    ...|.|....
Mouse    51 FADCVGDELPWGWEAGFDPQIGAYYIDHINKTTQIEDPRKQWRGEQEKMLK----DYLSVAQDAL 111

  Fly   618 PAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLV 682
            ..............|....:....::|.....::.|:            |..|:....||..|:
Mouse   112 RTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTS------------LFSGSSSSTKYDPDI- 163

  Fly   683 GKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKG---------- 737
                 |:.|:.|.|     .|::..:.|:......|:.|.:..:..:::..|..|
Mouse   164 -----LKAEISTTQ-----LRVKKLKRELSHMKQELLYKQQGFETLQQIDEKMSGGQSGYELNEA 218

  Fly   738 ----------EEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYF 792
                      .:.:..|...::.| :.|...|..::.|.|........|:.:|   || .|||
Mouse   219 KAILTELKSIRKAISSGEKEKQDL-MQSLAKLQERFHLDQNMGSSEPDLRSSP---VN-SHLS-- 276

  Fly   793 HFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIEST 857
                       .....||.|..|..          .||| ||     ||     .||::..:..:
Mouse   277 -----------LSRQTLDAGSQTSI----------SGDI-GV-----RS-----RSNLAEKVRLS 309

  Fly   858 FSVE--NNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIP- 919
            ...|  ..|...|.:...|..|.:.|...:.::|.:.| :|.:.....|.||:..||...|.:.
Mouse   310 LQYEEAKRSMANLKIELSKLDGEAWPGALDIEKEKLML-INEKEELLKELQFITPQKRSQEELER 373

  Fly   920 -----SHLLRPFDERELELVIGGIS-----SIDVNDWRNN--TRLKHCTNETTQVLWFWQVVESY 972
                 .||     |.||....|..|     .:.:.:.|..  .:|:..|..||.:   :..::|.
Mouse   374 LEAERQHL-----EEELMAARGSPSRALTERLKLEEKRKELLQKLEETTKLTTSL---YSQLQSL 430

  Fly   973 SSEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
            ||.    .|...:|||      ..:|..|.|::
Mouse   431 SSS----TLSMSSGSS------LGSLASSRGSL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/31 (29%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033	69/339 (20%)
		HECTc	726..1058	CDD:214523	65/315 (21%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809	9/31 (29%)
		WW	59..88	CDD:278809	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..464		6/22 (27%)
		C2_Kibra	699..822	CDD:176062
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..963
		Phage_Nu1	<1088..>1146	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900