DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and HERC5

DIOPT Version :10

Sequence 1:NP_523779.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_057407.2 Gene:HERC5 / 51191 HGNCID:24368 Length:1024 Species:Homo sapiens


Alignment Length:374 Identity:103/374 - (27%)
Similarity:177/374 - (47%) Gaps:52/374 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQY 768
            |.|.||.:.|:....:.:...:|:||.|.|.|.||.|.|.|||.:|:.:.|..||:.|:||:|.|
Human   683 LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMY 747

  Fly   769 SRDDHYTLQINPDSG------VNP--DHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
                       |:..      |.|  :...|| |.|...|:::|:.:..:..|....:|:||::.
Human   748 -----------PEGASCMWFPVKPKFEKKRYF-FFGVLCGLSLFNCNVANLPFPLALFKKLLDQM 800

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVH------ELKPGGASIPVTE 884
            .:|.|::.:.|||.::|..:|:.. ....|..|.:..|      ||      .|.|.|:||.|.:
Human   801 PSLEDLKELSPDLGKNLQTLLDDE-GDNFEEVFYIHFN------VHWDRNDTNLIPNGSSITVNQ 858

  Fly   885 ENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNN 949
            .|||:||..|:||.|...::..:...::||.::....:::.|...||:.||.|.:..|...:..|
Human   859 TNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKN 923

  Fly   950 TRLKHCTNET-TQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIH 1013
            .|.:...|.: ..::.||:.....:.|.:.:.|.|:||:.|:.::.              |..:.
Human   924 ARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKD--------------LNNMK 974

  Fly  1014 LTADVP---TQNLP-KAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            :|...|   .:..| :|.|||:.:.||.|.|.:.:.:.|.:|:....||
Human   975 ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_523779.1 C2_Smurf-like 14..135 CDD:176028
PRP40 155..>283 CDD:227435
WW 169..198 CDD:459800
WW 514..546 CDD:197736
WW 562..594 CDD:197736
HECTc 702..1058 CDD:238033 101/372 (27%)
HERC5NP_057407.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
RCC1 1 96..155
ATS1 <140..346 CDD:444065
RCC1 2 156..208
RCC1 3 209..260
RCC1 4 262..312
RCC1 5 314..364
HECTc 681..1024 CDD:238033 103/374 (28%)
Blue background indicates that the domain is not in the aligned region.

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