DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and HERC5

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	420	Identity:	115/420 - (27%)
Similarity:	194/420 - (46%)	Gaps:	65/420 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 QGLLEGADLLPKYRRDLVGK--LRALRTELQ-----TMQPQSGHCRLEVSRNEIFEESYRLIMKM 722
            |.|||   :|.|..|....|  ||:...|.:     .::|...   |.|.||.:.|:....:.:.
Human   719 QALLE---MLKKLHRSKKHKAYLRSAAIEEERESEFALRPTFD---LTVRRNHLIEDVLNQLSQF 777

  Fly   723 RAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSG---- 783
            ..:|:||.|.|.|.||.|.|.|||.:|:.:.|..||:.|:||:|.|           |:..
Human   778 ENEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMY-----------PEGASCMW 831

  Fly   784 --VNP--DHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTW 844
              |.|  :...|| |.|...|:::|:.:..:..|....:|:||::..:|.|::.:.|||.::|..
Human   832 FPVKPKFEKKRYF-FFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQT 895

  Fly   845 MLESNISGIIESTFSVENNSFGALVVH------ELKPGGASIPVTEENKREYVKLYVNYRFMRGI 903
            :|:.. ....|..|.:..|      ||      .|.|.|:||.|.:.|||:||..|:||.|...:
Human   896 LLDDE-GDNFEEVFYIHFN------VHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSV 953

  Fly   904 EQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNET-TQVLWFWQ 967
            :..:...::||.::....:::.|...||:.||.|.:..|...:..|.|.:...|.: ..::.||:
Human   954 KAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWK 1018

  Fly   968 VVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVP---TQNLP-KAHT 1028
            .....:.|.:.:.|.|:||:.|:.::.              |..:.:|...|   .:..| :|.|
Human  1019 AFHKLTLEEKKKFLVFLTGTDRLQMKD--------------LNNMKITFCCPESWNERDPIRALT 1069

  Fly  1029 CFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ||:.:.||.|.|.:.:.:.|.:|:....||
Human  1070 CFSVLFLPKYSTMETVEEALQEAINNNRGF 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	101/374 (27%)
		HECTc	726..1058	CDD:214523	96/350 (27%)
HERC5	XP_011530324.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810