Protein Alignment Smurf and Wwc2

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001102581.1
• Gene: Wwc2 / 498630
• RGDID: 1559427
• Length: 1194
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 122/552 - (22%)
• Similarity: 195/552 - (35%)
• Gaps: 142/552 - (25%)

  Fly   492 GSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLT 556
            ||||                 |.||.|:|......|:|::....|..::|.|   |||..|:.|:
  Rat     6 GSGQ-----------------LPLPRGWEEARDYDGKVFYIDHNTRRTSWID---PRDRLTKPLS 50

  Fly   557 L-DAIG-PLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLS--GSILQMIRRGTVPPTSAANAGT 617
            . |.:| .||.|||.........|::||.|:|||..|||..  |...:|::    ...|.|....
  Rat    51 FADCVGDELPWGWEAGFDPQIGAYYIDHINKTTQIEDPRKQWRGEQEKMLK----DYLSVAQDAL 111

  Fly   618 PAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLV 682
            ..............|....:....::|.....::.|:            |..|:....||..|:
  Rat   112 RTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTS------------LFSGSSSSTKYDPDI- 163

  Fly   683 GKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKG---------- 737
                 |:.|:.|.:     .|::..:.|:.:....|:.|.:..:..:::..|..|
  Rat   164 -----LKAEISTTR-----LRVKKLKRELSQMKQELLYKQQGFETLQQIDEKMSGGQSGYELSEA 218

  Fly   738 ----------EEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYF 792
                      .:.:..|...::.| :.|...|..::.|.|........|:.:|   || .|||
  Rat   219 KAILTELKSIRKAISSGEKEKQDL-MQSLAKLQERFHLDQNMGSSEPDLRCSP---VN-SHLS-- 276

  Fly   793 HFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIEST 857
                       .....||.|..|..          .||| ||     ||     .||::..:..:
  Rat   277 -----------LSRQTLDAGSQTSI----------SGDI-GV-----RS-----RSNLAEKVRLS 309

  Fly   858 FSVE--NNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPS 920
            ...|  ..|...|.:...|..|.:.|...:.::|.:.| :|.:.....|.||:..||    ....
  Rat   310 LQYEEAKRSMANLKIELSKLDGEAWPGALDVEKEKLML-INEKEELLKELQFITPQK----RTQD 369

  Fly   921 HLLRPFDER---ELELVIG-GISS------IDVNDWRNN--TRLKHCTNETTQVLWFWQVVESYS 973
            .|.|...||   |.|||.. |:.|      :.:.:.|..  .:|:..|..||   :.:..::|.|
  Rat   370 ELERLEAERQRLEEELVAARGLPSRALAERLKLEEKRKELLQKLEETTKLTT---YLYSQLKSLS 431

  Fly   974 SEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
            |.    .|...:|||      ..:|..|.|::
  Rat   432 SS----TLSMSSGSS------LGSLASSRGSL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/31 (29%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033	71/338 (21%)
		HECTc	726..1058	CDD:214523	67/314 (21%)
Wwc2	NP_001102581.1	WW	12..41	CDD:278809	9/31 (29%)
		WW	59..88	CDD:278809	12/28 (43%)
		DUF342	<283..385	CDD:302792	31/127 (24%)
		YlqD	351..>420	CDD:287979	18/72 (25%)
		C2_Kibra	699..822	CDD:176062
		Phage_Nu1	<1095..>1153	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900