DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and arel1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	191/725 - (26%)
Similarity:	281/725 - (38%)	Gaps:	165/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 SSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRY----ASAAIAAANQAARPF--LDLPPGY 519
            |:|...:.:.|.|:|.|...|  .|.||...|....|    ..|.:.:..|....|  |.|..|
Frog   121 STRNVMKVAFTVRKSGRYQIN--ISIGGLNIGHSPYYKIFSPGAVVPSKTQIVSHFSTLVLKCG- 182

  Fly   520 EMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIG--PLPSGWEQRKTASGRVYFVDH 582
            |..|.|.       :|......|.....:|.::..|||..:|  .:..|..|....||      .
Frog   183 EQHTLQV-------VPRDQYGNHTSDSLKDLESYILTLSELGVVGVADGCLQVSVCSG------S 234

  Fly   583 NNR---------------TTQFTDPRLSGSILQMI----RRGTVPPTSAANAGTPA-------PP 621
            .||               |.:|....::....|:|    ...|:...:.:.:|...       ||
Frog   235 QNRVLLHLALLQTGCFQATLRFQGLPINNGNFQIIVLTDGEKTIVDNNVSRSGVGVFFEGYLYPP 299

  Fly   622 SATPATPSAAAAVPPQATPASNATPTTLTTTTNP----------------------PHRIV---- 660
            |::|..|....:........|||...|:.....|                      |.|:.
Frog   300 SSSPNIPGQHRSSSTSNDEESNADGHTVDRLKKPKKVYFYITPKQLSVKEFYLRIIPWRLFTFRV 364

  Fly   661 ----------PDLPQGLL-----EGAD------------LLPKYRRDL---VG-------KLRAL 688
                      ||...|||     :|..            :...:.|.|   :|       |:...
Frog   365 CPGTKFLYLPPDPLHGLLSLQVDDGLQPPIEISCKDRNIMAATFTRFLHLNIGGSETFQDKVTFF 429

  Fly   689 RTELQTMQPQSGHCR--LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWL 751
            :.||:.:..:...|:  |:|:|:.:.|.|.|......|.|..|...|.|:.||.||:||..|||.
Frog   430 QKELRQIHCKKTRCKVTLKVNRHSLLESSLRATRNFSASDWCKNFEVVFQDEEALDWGGPRREWF 494

  Fly   752 HLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPD-HLSYFHFVGRTLGIAVFHGHCLDGG--- 812
            .|:.:.:.:....||....|.:..| ::|:....|: .:..:.|.||.:|..:|.. .|.||
Frog   495 ELICKTLFDTNNQLFIRFSDSNQGL-VHPNPCRPPNIRVKLYEFAGRVVGKCLFES-SLGGGCEQ 557

  Fly   813 -----FTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGAL---- 868
                 ||..|..|::...:.....|..|||..::....:.:|  .:|::..|.....:|..
Frog   558 LVRARFTRSFLAQIIGLRMHYKYFETDDPDFFQTKVQYILTN--DVIDTELSFAEEKYGRAGQLE 620

  Fly   869 VVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELEL 933
            .|.||.|||:.|.||.|||..|:.|..|:|....:.::.....||..||:|.:||..|||.||||
Frog   621 KVVELIPGGSQILVTNENKVYYLNLLANHRLSNQVREEVDHFLKGLNELVPDNLLGIFDENELEL 685

  Fly   934 VIGGISSIDVND-----------WRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGS 987
            ::.|...|.|.|           |....::         :.|||.||.|.:.|..||||||.|||
Frog   686 LMCGTGHIAVQDFQAHAVVIGGSWHFREKV---------MSWFWAVVSSLTQEELARLLQFTTGS 741

  Fly   988 SRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQ-NLPKAHTCFNRIDLPPYETYQLLCDKLTQA 1051
            |::|..||.||..|...:|.           ||. .||.||||||::.||.|::|:.:...|..|
Frog   742 SQLPPGGFAALSPSFQIIGS-----------PTHGTLPTAHTCFNQLCLPTYDSYEEMHKMLKLA 795

  Fly  1052 VEETC-GFAV 1060
            :.|.| ||.:
Frog   796 ISEGCEGFGM 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	7/31 (23%)
		WW	562..594	CDD:197736	8/46 (17%)
		HECTc	702..1058	CDD:238033	125/383 (33%)
		HECTc	726..1058	CDD:214523	117/357 (33%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210	11/33 (33%)
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	125/380 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910