Protein Alignment Smurf and NEDD4

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001271267.1
• Gene: NEDD4 / 4734
• HGNCID: 7727
• Length: 1319
• Species: Homo sapiens
• Alignment Length: 1038
• Identity: 323/1038 - (31%)
• Similarity: 448/1038 - (43%)
• Gaps: 314/1038 - (30%)

  Fly    92 FLGCVRIPAFNI--------------------QSLKG--AGFQRLDLGKL-----SPDD-----D 124
            |||.|.:|.:.:                    :|.|.  .|:.||.:..|     |.||     :
Human   521 FLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAE 585

  Fly   125 ELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHA 189
            ||..|.:::     |.|.:...|             :.......||.|||||:...||.|||||.
Human   586 ELEPGWVVL-----DQPDAACHL-------------QQQQEPSPLPPGWEERQDILGRTYYVNHE 632

  Fly   190 TKSTQWDRPRQPGVVGSSHATSPQQR-HNTHNGNSGDRQAPAGPTRSTTC--TNLMNNGHRSRDL 251
            ::.|||.||            :||.. .:..|||...:...|..||....  |..::|...|.:.
Human   633 SRRTQWKRP------------TPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENW 685

  Fly   252 SVTASDERRHSTEILSSVGKENTSPTTPVSA--------------------TTTPGKKTSSSNSS 296
            .:...||        :::......|:.|.|:                    .:...:..||||.|
Human   686 EIIREDE--------ATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHS 742

  Fly   297 SAGGR----TLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQN 357
            |..|.    |.|::||.....||||                       |..|.........|:..
Human   743 SRRGSLQAYTFEEQPTLPVLLPTSS-----------------------GLPPGWEEKQDERGRSY 784

  Fly   358 YVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVT 422
            ||:.|                  |.:..||:.....|...|..||    |||
Human   785 YVDHN------------------SRTTTWTKPTVQATVETSQLTS----SQS------------- 814

  Fly   423 PSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGG 487
                              |.|.....:.:..||:..:.|..:||
Human   815 ------------------SAGPQSQASTSDSGQQVTQPSEIEQG--------------------- 840

  Fly   488 GGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPR--IPRDF 550
                                      .||.|:|:|....|:.:|....|..:||.|||  ||
Human   841 --------------------------FLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIP--- 876

  Fly   551 DTQHL-------TLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVP 608
              .||       |.:.:||||.|||:|....||:::::||.:.||:.||||.
Human   877 --AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLE------------- 926

  Fly   609 PTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADL 673
                 |.....|            |||
Human   927 -----NVAITGP------------AVP-------------------------------------- 936

  Fly   674 LPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKD-MRKRLMVKFKG 737
               |.||...|....|.:|:..........:::.|..:.|:|||.||.::..| ::.||.::|.|
Human   937 ---YSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDG 998

  Fly   738 EEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGV-NPDHLSYFHFVGRTLGI 801
            |:|||||||||||..|:|:||.||.||||:||..|:|||||||:||: |.||||||.|:||..|:
Human   999 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGM 1063

  Fly   802 AVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFG 866
            ||:||..|||.|..||||.:|:|||||.|:|.||.:.:.||.|:||::.:. ::..|.::...||
Human  1064 AVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFG 1127

  Fly   867 ALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDEREL 931
            ....||||.||:.|.||.:||:||:.|.:.:||:..|::|..|.::||.||||..|::.|||.||
Human  1128 QTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENEL 1192

  Fly   932 ELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGF 995
            ||::.|:..:||||||.:|:.|:..:...||: |||:.|....||.|.||||||||:||||:.||
Human  1193 ELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGF 1257

  Fly   996 RALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ..|.||.   ||:.||:....  ..:.||:|||||||:||||||:::.|.|||..|:|.|.||
Human  1258 AELYGSN---GPQSFTVEQWG--TPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	17/74 (23%)
		WW	169..198	CDD:278809	17/28 (61%)
		WW	514..546	CDD:197736	13/33 (39%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033	181/358 (51%)
		HECTc	726..1058	CDD:214523	174/334 (52%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..229
		C2	<517..570	CDD:417471	10/48 (21%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		134/639 (21%)
		WW	611..643	CDD:197736	19/43 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..780		8/47 (17%)
		WW	769..798	CDD:395320	8/46 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	796..834		12/72 (17%)
		WW	842..871	CDD:395320	10/28 (36%)
		WW	893..925	CDD:197736	15/31 (48%)
		HECTc	986..1315	CDD:214523	174/334 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740