DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and bag3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001003533.1	Gene:	bag3 / 445139	ZFINID:	ZDB-GENE-040801-40	Length:	459	Species:	Danio rerio

Alignment Length:	247	Identity:	60/247 - (24%)
Similarity:	87/247 - (35%)	Gaps:	83/247 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 PLPSGWEQR-KTASGRVYFVDHNNRTTQFTDPR------------LSGSILQ------------- 600
            |||.|||.: ...:|..:|||||||||.:.|||            :|....|
Zfish     6 PLPPGWEIKIDPQTGWPFFVDHNNRTTTWNDPRHDTKKIFSNGPSMSPETPQDMHKTFINEMRQP 70

  Fly   601 MIRRGTVP----------------------PTSAAN----AGTPAPPSATPATPSAAAAVPPQAT 639
            |:|:|.:|                      |....|    ..||:|..|....|.:....|.:|
Zfish    71 MLRQGYIPIPVCHENPEPRLQQYPSFSYIHPAVQQNLRTDGRTPSPTPAAHCRPRSPVQTPSEA- 134

  Fly   640 PASNATPTTLTTTTNPP---HRIVPDLPQ-------GLLEGADLLPKYRRDLVGKLRALRTELQT 694
             .|:.:||:.......|   |:.:..|.|       ||..|...:|.......|   .|.::|.
Zfish   135 -CSSCSPTSHGPEGYQPQGTHQQISGLHQQPRSSNTGLRAGYIPIPVIHEGAGG---VLPSQLS- 194

  Fly   695 MQPQSGHCRLEVSRNEIFEESYRL-IMKMRAKD-------MRKRLMVKFKGE 738
               ||.|    .:|.:|:.|...: |.:.||..       .:..:|.:..||
Zfish   195 ---QSSH----PTREKIYREQVPIQIQQNRAASPIQVPLRAQSPVMAQIMGE 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736	19/44 (43%)
		HECTc	702..1058	CDD:238033	9/45 (20%)
		HECTc	726..1058	CDD:214523	3/20 (15%)
bag3	NP_001003533.1	WW	6..38	CDD:197736	17/31 (55%)
bag3	NP_001003533.1	BAG	358..432	CDD:214591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900