DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smurf and hyd

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster


Alignment Length:1485 Identity:283/1485 - (19%)
Similarity:451/1485 - (30%) Gaps:563/1485 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 HKVRITILCARNLA-----RKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFL-- 70
            ||:.|..||..:.|     |..:.|...||.              :|.|:||.: |:. |||.  
  Fly  1526 HKISIEELCEVSEALIAPVRLGVVRPTAPFT--------------MSSSNLDVR-NSD-DLFSVD 1574

  Fly    71 GIGDAITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSP-------------- 121
            .:..:...:...|..:|..    |..:...||||       |..|:..:..              
  Fly  1575 PLAPSNVESPSEQILVHDA----GNDQSANFNIQ-------QNYDVVAMETIRDASESEEVINRE 1628

  Fly   122 -----DDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNG 181
                 .||||:..|     .::||                   .:||.|::.......|..:|:.
  Fly  1629 ANSHNQDDELIENQ-----RNEDG-------------------MQDDESDNDFTFNDAETESDSD 1669

  Fly   182 RVYYVNHATKSTQWDRPRQPG-VVGS------------SHATSPQQRHNTHNGNSGD-------- 225
            .    |.:.:..|  |..|.| .|||            |..:|.|:...:.:|.|.|        
  Fly  1670 D----NQSNQEVQ--RSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFN 1728

  Fly   226 -----RQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSP------TTP 279
                 |::.....||......|....||||.:       |.|..:.:........|      |.|
  Fly  1729 EQQLERRSTNSNARSDLAPQTMQWAIRSRDTA-------RSSVRVPTGSNMVFIDPMALRRSTVP 1786

  Fly   280 VSAT-TTPG-----KKTSSSNSSSAGGRTLEQ--------------------RPTNEPATPTSS- 317
            .|.| |||.     ..|::||.:.|.|.|:.|                    :..|:.|....: 
  Fly  1787 ASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAF 1851

  Fly   318 -----------------TTSASVRL------HSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYV 359
                             .|.|.::.      :::.||   |.|..|..|...|:.|......:.|
  Fly  1852 VEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNH---PLHPLNLSAQASSSQTPAPATSSSV 1913

  Fly   360 NGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRH------------------ 406
            ||....||.|.............|:.....||.    |....:..||                  
  Fly  1914 NGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDAL----PVLDITALRHIAYVLDAFVYYMRNDSGF 1974

  Fly   407 -----SQSPPTPNISPPASV--TPSANGNVHSPN------ANSTPAGSGGGSR-SYTAATPGQRS 457
                 :.|....|:||....  |.....|:...|      |:|.|:||.|..| ::.|.:....|
  Fly  1975 YDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLS 2039

  Fly   458 --------------------------QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQR 496
                                      |..|.||:...:.....::....:|.|:.|.||.     
  Fly  2040 LGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGS----- 2099

  Fly   497 YASAAIAAANQAARPFLDLPP---GYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLD 558
                           ..|..|   |:.....:..:|| ..:|...|...|..:         |..
  Fly  2100 ---------------IFDYTPTRLGFSNSLKRNERVY-ETVPIDSSKTGDGNV---------TNK 2139

  Fly   559 AIGPLPSG-WEQRKTASGRVYFVDHNNRTTQFTDPRLS--GSILQMIRRGTVPPTS----AANAG 616
            |.|...|. :.|.|...|...|..|..     .|...|  ..::.|....::|.||    |..|.
  Fly  2140 AEGSTDSNIYVQLKKKQGSDDFKSHKE-----ADGNQSKYEKVVLMETDDSLPSTSKSTEALMAT 2199

  Fly   617 TP----APPSATPATPSAAAAVPPQA---------TPASNATPTTLTTT-----------TNPPH 657
            .|    ||..|:.:..:||.:|...|         :..:|.:.:.|:|.           :...|
  Fly  2200 RPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDH 2264

  Fly   658 RIV-------------PDLPQ-----------------------GLLEGADLLPKYRRDLVGKLR 686
            .::             .:||.                       |:..|: :||:.|...|.::|
  Fly  2265 LLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGS-VLPELRGFPVKEMR 2328

  Fly   687 ALRTELQTMQPQSGH------CRLEVSRNEIFEESYRLIMKMRAKDMRK--------RLMVKFKG 737
             .|..::.:  ::|.      |:||.:|..:..::::.:........|:        |:.|.||.
  Fly  2329 -FRRHMEKL--RNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKD 2390

  Fly   738 EEGLDYGGVAREWLHLLSREML---------NPQYGL--FQY---------------SRDDHYTL 776
            |.| :..||||.:...::..:|         :.|.|.  .:|               |..|..||
  Fly  2391 EPG-EGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTL 2454

  Fly   777 Q------------------IN--------PDSGVNP------DHLSY------------------ 791
            |                  :|        |:|..|.      ||||.                  
  Fly  2455 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQ 2519

  Fly   792 ----------------------------------------------------------------- 791
                                                                             
  Fly  2520 THAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDP 2584

  Fly   792 --------------------------------FHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNK 824
                                            |..:||.:|:.:.....|.........|.:|.:
  Fly  2585 VDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGR 2649

  Fly   825 PITLGDIEGVDPDLHRSLTWML--------ESNISGIIESTFSVENNSFGALVVHELKPGGASIP 881
            .|...|:...||.|:.|...::        |..|:. :|..|.::..........||.|||..:.
  Fly  2650 KIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINR-MELCFVIDLMKEEGCGNRELIPGGRDVA 2713

  Fly   882 VTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDW 946
            ||..|..|||:.|..||.::..|:...||:.|..:::|.:.:......:|.|::.|:..|:|:..
  Fly  2714 VTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTL 2778

  Fly   947 RNNTRLKHCTNETTQVL-----WFWQVVESYSSEMRARLLQFVTGSSRVPL--QGFRALQGSTGA 1004
            .:.|.....::|....|     |||.:||..:...|..|:.|.|||..:|.  :||:.|...|  
  Fly  2779 ISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVT-- 2841

  Fly  1005 VGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVE-ETCGF 1058
            :.|        ||  ..:||.|:||.:|:.:|.|.:..:|..|:..|:: :..||
  Fly  2842 IRP--------AD--DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 31/146 (21%)
WW 169..198 CDD:278809 4/28 (14%)
WW 514..546 CDD:197736 8/34 (24%)
WW 562..594 CDD:197736 7/32 (22%)
HECTc 702..1058 CDD:238033 106/552 (19%)
HECTc 726..1058 CDD:214523 102/528 (19%)
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562 48/254 (19%)
PolyA 2498..2561 CDD:197769 3/62 (5%)
HECTc 2589..2885 CDD:238033 74/308 (24%)
HECTc 2589..2884 CDD:214523 74/307 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446964
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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