DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Ube3a

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	1104	Identity:	224/1104 - (20%)
Similarity:	380/1104 - (34%)	Gaps:	393/1104 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 NTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDL--SVTASDERRHSTEILSSVGKENTSPTTP 279
            |...|...|:..|...:.|.:....: .|..:.::  |...|..:|:..::.|..|..|
  Fly     2 NGGGGGEDDQHLPGVSSASGSAAGAV-GGRATPEMKRSAVRSLIKRYFHQLQSGCGNAN------ 59

  Fly   280 VSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAP 344
                      .|::|.:|:|        ...|.|| :...:.:::|.|.|..: .....:..::|
  Fly    60 ----------CSNANCASSG--------KVAPMTP-NEVAARALQLFSQDAQL-CEAFTSEANSP 104

  Fly   345 PESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQS 409
            .:....||         |..:.|:||:.:                  :|.||.||||:..|.|||
  Fly   105 QDVDMLSP---------NDSSSSSSGSST------------------STITSASTTTTTSRQSQS 142

  Fly   410 PPTPNISPPAS--VTPS-----------ANGN----------VHSPNANS--------------- 436
            .|...:.|.:|  :|.|           ::|:          |||.:|||
  Fly   143 TPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYD 207

  Fly   437 ------------------------TPAGS-----------GGGSRSYTAATPGQRSQRRSSRQQG 466
                                    .||.|           |..::.......|:..:...|.||.
  Fly   208 RICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQV 272

  Fly   467 EESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPP---------GYEMR 522
            :|.|....::..|.....|       ..:.........::|::...:|||.         |.::|
  Fly   273 DEQSESAANATATAESVES-------EAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIR 330

  Fly   523 TTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLT------LDAIGPLPSGWEQ-----------R 570
            ..                           |:.||      .|.:..:.:.||:           .
  Fly   331 AI---------------------------TEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLA 368

  Fly   571 KTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAA---- 631
            ...:..|..:|:.:|                    .:|....|.:..|.|..|..|...||
  Fly   369 TNTNNSVVDMDYLDR--------------------VLPKLCQAASAMPVPAQARLARIWAAHCSD 413

  Fly   632 ------AAVPPQAT-------------------------------------------PASNATPT 647
                  ||...|.|                                           |..:.|.
  Fly   414 QLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTE- 477

  Fly   648 TLTTTTNPPHRIVPDL--PQGLLEGADLLPKYRRDLVGK--------------------LRALRT 690
              ..|.:....:..||  ...|||  ..:||:..|...|                    ..||..
  Fly   478 --AATASGSAAVEDDLFVYNSLLE--PHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSE 538

  Fly   691 ELQ-----------TMQPQ--SGHC---------------------------------------- 702
            .:|           .|:.:  |||.
  Fly   539 NIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSI 603

  Fly   703 -----------------RLEVSRNEIFEES---YRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVA 747
                             :|.|.|:::..::   ..::.....||::|:|:|:|.||:|:|.|||:
  Fly   604 LNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVS 668

  Fly   748 REWLHLLSREMLNPQYGLF-QYSRDDHYTLQINP-DSGVNPDHLSYFHFVGRTLGIAVFHGHCLD 810
            :|:..|:..|:.||.:|:| |....::......| ::|      :.|..:|..:|:|:::...|.
  Fly   669 KEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG------AQFTLIGIIIGLAIYNNVTLA 727

  Fly   811 GGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLE---SNISGIIESTFSVE-NNSFGALVVH 871
            ..|....|::|:....|..|:....|.|::||..||:   .::..:.|.||.:. ::.||.:|.|
  Fly   728 VNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQH 792

  Fly   872 ELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELI----PSHLLRPFDERELE 932
            ||.|.|..:.|.:.||..:|.||.::.....|||||.|.:||| |::    |..||  |...|:|
  Fly   793 ELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGF-EMVTDESPLKLL--FRPEEIE 854

  Fly   933 LVIGGISSIDVNDWRNNTRLKHCTNETTQVLW-FWQVVESYSSEMRARLLQFVTGSSRVPLQGFR 996
            :::.|....|..:..|:|..:....|.:|.:. ||.:|.:..||.:.:||:|.|||:|||:.|.:
  Fly   855 MLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLK 919

  Fly   997 ALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
            .|:......||           .:..||.:|||||.:.||.|.:.:.|.::|.:|:..:.||.:
  Fly   920 CLRLLITRHGP-----------DSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	5/40 (13%)
		WW	562..594	CDD:197736	5/42 (12%)
		HECTc	702..1058	CDD:238033	112/426 (26%)
		HECTc	726..1058	CDD:214523	108/342 (32%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/79 (19%)
		HECTc	620..971	CDD:238033	113/370 (31%)
		HECTc	647..970	CDD:214523	108/342 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740