DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Herc4

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	119/369 - (32%)
Similarity:	195/369 - (52%)	Gaps:	22/369 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 PQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNP 761
            |.|....|.|:|..:.::|.|.:......|::|.|.:||.|||..|.|||.:|:..||.:::|:|
  Fly   710 PISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDP 774

  Fly   762 QYGLF-QYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
            :||:| :|.:.   .|....|.....::: || .:|...|:|:::...::..|....:|:||.||
  Fly   775 KYGMFKEYEQS---RLLWFADLTFETENM-YF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKP 834

  Fly   826 ITLGDIEGVDPDLHRSLTWMLE---SNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENK 887
            :.|.|:..:.|....|:..:|:   .:...:.:.||.:..:.||......|||.|..|.||.||:
  Fly   835 VDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENR 899

  Fly   888 REYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRL 952
            :|:|.|||::.|.:.:|..:.|..|||.::....::..|...||..|:.|....|....::|...
  Fly   900 QEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEY 964

  Fly   953 KH-CTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTA 1016
            :. .|:....:.|||:|:...|...:...|.|:|||.|:|:||.:||:          .||..|.
  Fly   965 REGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK----------LTIQPTP 1019

  Fly  1017 DVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
            |  .:.||.||||||.:|||.|:|.:.|..||.||:::|.||::
  Fly  1020 D--ERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	115/360 (32%)
		HECTc	726..1058	CDD:214523	110/336 (33%)
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	116/361 (32%)
		HECTc	739..1059	CDD:214523	110/336 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740