DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and CG3356

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	114/373 - (30%)
Similarity:	194/373 - (52%)	Gaps:	37/373 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKG-----EEGLDYGGVAREWLHLLSREMLNPQY 763
            :.|.|:.::|::|..:......|:|.:..::|..     |.|:|.|||.||:|..|.:...:|..
  Fly   766 ITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNR 830

  Fly   764 GLFQYSRDDHYTLQINPD-SGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNK--P 825
            |.|..:.|:  .|..||: :.:..|:..:::|:||.||.:::....::......|..:|..|  .
  Fly   831 GFFMVTTDN--KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSD 893

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIES---TFSVENNSFGALVVHELKPGGASIPVTEENK 887
            :.:..:..:||:|:|:|.::  .:.||.:..   .|:|.::|.|...:.||||.|.|||||..|:
  Fly   894 VDIHQLASLDPELYRNLLYL--KDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNR 956

  Fly   888 REYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGIS-SIDVNDWRNNTR 951
            .||::|..:|:....|.:...|.:||...::|...|..|..:||:::|.|.. .||:.|.:
  Fly   957 IEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLK---- 1017

  Fly   952 LKHC------TNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLF 1010
             |||      :.|...::.||:|:|.:....|.:||:|||..||.||.||:.|.       |..|
  Fly  1018 -KHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLD-------PPFF 1074

  Fly  1011 TIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
             |..|.|:  :.||.|.||.|.:.|||::|.:.:.:||..|::...||
  Fly  1075 -IQNTGDM--ERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	112/371 (30%)
		HECTc	726..1058	CDD:214523	108/349 (31%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	114/373 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	108/349 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740