DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Hectd1

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus


Alignment Length:1420 Identity:273/1420 - (19%)
Similarity:436/1420 - (30%) Gaps:537/1420 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 LGKLSPDDD-------ELVRGQIIISLL--------------SKDGPSSGNPLAIVGPSGDVRGP 159
            |||.:.:.:       .|||.|::..::              .:||...|        .|.|.| 
  Rat  1248 LGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQG--------EGTVTG- 1303

  Fly   160 SEDDSSEDSLPEGWEERRTDNG--RVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNG- 221
                    .|..||.:...|.|  ..|.:....|   :|....||....:.| ||:...:|.:| 
  Rat  1304 --------ELHNGWIDVTWDAGGSNSYRMGAEGK---FDLKLAPGYDPDTVA-SPKPVSSTVSGT 1356

  Fly   222 ----------NSGDR-QAPAGPTRSTTCTNLMNNGHRSRDLSV-TASDERR------HS------ 262
                      |..|: .|.||.:.....::.:.:...|.|:|: :...|||      ||      
  Rat  1357 TQSWSSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGAD 1421

  Fly   263 ----TEILSS--------VGKENTSPTTPVSATT----------------TPGKKTSSS----NS 295
                ..:|||        ||..:::.|:.::|.|                .||:.::.|    :.
  Rat  1422 VHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRAPGESSAISMGIVSV 1486

  Fly   296 SSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVN 360
            ||....::.:....|.|:....::|||.|| |..:.:......::..:.|..:....:..:::|.
  Rat  1487 SSPDVSSVSELTNKEAASQRPLSSSASNRL-SVSSLLAAGAPMSSSASVPNLSSRETSSLESFVR 1550

  Fly   361 GNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTT----SPSTTTSPPRHSQSPPTPNISPP--- 418
            ..|....|:...:...::..|.:|        |.|    ..||.|||...:||  .||::.|   
  Rat  1551 RVANIARTNATNNMNLSRSSSDNN--------TNTLGRNVMSTATSPLMGAQS--FPNLTTPGTT 1605

  Fly   419 ASVTPSANGNVHSPN-ANSTPAGSGGGSRSYTAAT----------PGQRSQ----------RRSS 462
            ::||.|.:....|.| |.:|...|.|.|.|.|..|          .||.::          |.|:
  Rat  1606 STVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRAST 1670

  Fly   463 ---------------------------RQQGEESSTRRRSSRGTRNGGTS--------------- 485
                                       .|:.||....||.|...|.|..|               
  Rat  1671 LLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVP 1735

  Fly   486 GGGGGGGSGQ-----------------------RYASAAIAA-------ANQAARPFLDLPPG-- 518
            .|.|....|:                       |..||.:.|       .|......|::||.  
  Rat  1736 SGAGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT 1800

  Fly   519 ------YEMRTTQQGQVYFYHIPTGVSTWHDPRIPRD--------FDTQHLTLDAIGPLPSG--- 566
                  .|:..|...::......||:.|..:..:|..        :..:.|.|...|.:.|.   
  Rat  1801 PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLR 1865

  Fly   567 --WE-------------QRKTASGRV--------------------------------YFVDHNN 584
              ||             .::..:|::                                .|:.|..
  Rat  1866 RIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWK 1930

  Fly   585 RTTQFTDPRLSGSILQMI-------RRGTVPPTSAANAGTPAPPSA------TPATPSAAAA--- 633
            .|......|.:.:..|:|       ..||   .|..|.|..:...:      |...|.|.|.   
  Rat  1931 LTGTNKSIRKNRNCSQLIAAYKDFCEHGT---RSGLNQGASSSLQSSDILNLTKEQPQAKAGNGQ 1992

  Fly   634 --------------------------------VPPQAT-PASNATPTTLTTTTNPPHRIVPDLPQ 665
                                            ..||.| |....|...:||      :|:..:.:
  Rat  1993 NPCGVEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITT------KILQQIEE 2051

  Fly   666 GLLEGADLLPKYRRDLVGKL---------------------RAL--------------RTELQTM 695
            .|...:..||.:...|..|.                     ||:              ||.....
  Rat  2052 PLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVR 2116

  Fly   696 QPQSG--------HCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLH 752
            :...|        |.|::|.|.|...|....:|::.| |.:..|.|:|.||||...|... |:..
  Rat  2117 RDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHA-DRKSVLEVEFLGEEGTGLGPTL-EFYA 2179

  Fly   753 LLSREMLNPQYGLFQYSRDDHY----TLQINPDSGVNP--------------------DHL---- 789
            |::.|......|  .:..||::    :..::...|:.|                    |.|    
  Rat  2180 LVAAEFQRTDLG--TWLCDDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERIT 2242

  Fly   790 SYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEG----------VDPDLHRS--- 841
            ..|||:|..|...:.....:|...:.||:|.:     .:|||:.          .|.|||.:   
  Rat  2243 KLFHFLGIFLAKCIQDNRLVDLPISKPFFKLM-----CMGDIKSNMSKLIYESRGDRDLHCTESQ 2302

  Fly   842 -----------------------------------------LTW--------------------- 844
                                                     |||                     
  Rat  2303 SEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLA 2367

  Fly   845 -----------------------MLESNISGI----------IESTFSVENNSFGALVVHELKPG 876
                                   ::..|.||.          :...|...:..:|...| :|||.
  Rat  2368 IKRRQILGNKSLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAV-DLKPS 2431

  Fly   877 GASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSI 941
            |....:|.:|..|||.|..::....||::|..|.:.||.::.|...|..|...|:::::.|..|.
  Rat  2432 GEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSP 2496

  Fly   942 D--VNDWRNNTRLK-HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTG 1003
            .  ..|..|.|..| ..|.::...|.|.:|:...||:.|...|||.||.|.:|..|...|.    
  Rat  2497 SWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLH---- 2557

  Fly  1004 AVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
               ||| |:....|....:.|..:||.:.:.||.|.:.:::.::|..|..|. ||
  Rat  2558 ---PRL-TVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEK-GF 2607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 7/25 (28%)
WW 169..198 CDD:278809 8/30 (27%)
WW 514..546 CDD:197736 7/39 (18%)
WW 562..594 CDD:197736 7/81 (9%)
HECTc 702..1058 CDD:238033 107/494 (22%)
HECTc 726..1058 CDD:214523 100/470 (21%)
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560
ANK repeat 366..393 CDD:293786
ANK 369..479 CDD:238125
ANK repeat 396..426 CDD:293786
ANK repeat 428..457 CDD:293786
F5_F8_type_C 1107..1240 CDD:304887
MIB_HERC2 1277..1335 CDD:284184 14/77 (18%)
HECTc 2131..2608 CDD:238033 109/496 (22%)
HECTc 2155..2607 CDD:214523 99/469 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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