DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Ube3a

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	120/382 - (31%)
Similarity:	201/382 - (52%)	Gaps:	38/382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   693 QTMQPQSGHCRLEVSRNEIFEES---YRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLL 754
            |.:.|   :.||:|.|:.|.:::   ..:|......|::|:|.|:|:||:|:|.|||::|:..|:
  Rat   510 QQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLV 571

  Fly   755 SREMLNPQYGLFQYSRDDHYT--LQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPF 817
            ..|:.||..|:|.|   |..|  ...||.|.   :....|..:|..||:|:::...||..|....
  Rat   572 VEEIFNPDIGMFTY---DEATRLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 630

  Fly   818 YKQLLNKPITLGDIEGVDPDLHRSLTWML--ESNISGIIESTFSV-ENNSFGALVVHELKPGGAS 879
            |::|:.|..|..|:....|.|::||..:|  |.|:...:..||.: :.:.||..::::||..|..
  Rat   631 YRKLMGKKGTFCDLGDSHPILYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDK 695

  Fly   880 IPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPS-----HLLRPFDERELELVIGGIS 939
            ||:|.||::|:|.||.:|...:.:|:||.|.::|| .::.:     :|.||   .|:||:|.|..
  Rat   696 IPITNENRKEFVSLYSDYILNKSVEKQFKAFRRGF-HMVTNESPLKYLFRP---EEIELLICGSR 756

  Fly   940 SIDVNDWRNNTRLK-HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTG 1003
            ::|.......|... ..|.|:..:..||::|.|::.|.:...|||.||:.|.|:.|...|:....
  Rat   757 NLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIA 821

  Fly  1004 AVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
            ..||           .|:.||.:|||||.:.||.|.:.:.|.::|.:|:....||.:
  Rat   822 KNGP-----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	116/369 (31%)
		HECTc	726..1058	CDD:214523	110/342 (32%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	117/370 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810