Protein Alignment Smurf and Su(dx)

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001259898.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 1112
• Identity: 344/1112 - (30%)
• Similarity: 485/1112 - (43%)
• Gaps: 270/1112 - (24%)

  Fly    11 GTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDA 75
            |.|::.:||..|.  .|.:.|..|:|:.::.:|...: ..|::.|:|..||||..:
  Fly    47 GYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEF--------- 99

  Fly    76 ITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLL---- 136
             |:.:.....:|                       |:.||......|   .:.|:.||:|.
  Fly   100 -TVLITPNSTLH-----------------------FKVLDHSSFRKD---AMLGERIINLAHILQ 137

  Fly   137 SKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQP 201
            ..:|......|.|     |:...|:.|:           |:|.:|.:..:.:..|........||
  Fly   138 HYNGRCEFLELTI-----DLFVTSKSDN-----------RQTKSGELVAILNGLKLDMSKLQIQP 186

  Fly   202 GVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEIL 266
             |.|..:...|.|..|.    |....|.||    .:|  ::..|.|:|
  Fly   187 -VAGQQNGNPPVQAVNP----SVVSDAAAG----RSC--MIYGGVRAR----------------- 223

  Fly   267 SSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNH 331
                                 .:..||:.:|.||.|....|..                 ..|
  Fly   224 ---------------------MRLRSSSGNSNGGETRSPLPNG-----------------GGD-- 248

  Fly   332 VKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTS 396
                 |:.:..|||      ...||...:.|.|......|||| ||.||:|.
  Fly   249 -----HRRSTQAPP------VWEQQQQQSQNQQQPLRMVNGSG-AAVPQTAP------------- 288

  Fly   397 PSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGG-----GSRSYTAATPG-- 454
                     :.|.||.|.::.|.:....|......|.|...|||.|.     |........||
  Fly   289 ---------YPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVG 344

  Fly   455 ----QRSQRRSSRQQGEE----SSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARP 511
                |.:..:...|..::    :....|..:               .|:||.......:....:|
  Fly   345 LPVSQSTDPQLQTQPADDEPLPAGWEIRLDQ---------------YGRRYYVDHNTRSTYWEKP 394

  Fly   512 FLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQH---------------------- 554
             ..||||:|:|...:|:||:....|..:||..|...|....||
  Fly   395 -TPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQ 458

  Fly   555 -----LTL-------DAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTV 607
                 :|.       ||:||||.|||::..:..|||||:|.|||||:.|||..|..:.:|..|.:
  Fly   459 QQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPL 523

  Fly   608 PP------TSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQG 666
            ||      |:|..                          .......|..||...|.   |..|:|
  Fly   524 PPGWEIRYTAAGE--------------------------RFFVDHNTRRTTFEDPR---PGAPKG 559

  Fly   667 LLEGADLLPK-YRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKR 730
             .:|...:|: |.|....||...|...|:....| |.::.|:|..:||:||..||::.|.::|:|
  Fly   560 -AKGVYGVPRAYERSFRWKLSQFRYLCQSNALPS-HIKITVTRQTLFEDSYHQIMRLPAYELRRR 622

  Fly   731 LMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFV 795
            |.:.|:||||||||||:|||..|||.|:|||.|.||:|:..::|:|||||.|.||||||.||.|:
  Fly   623 LYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFI 687

  Fly   796 GRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFS 859
            ||.:.:|::||..:..|||.||||::|||.:|:.|||.:||:.:.||.|:.::||... :|..||
  Fly   688 GRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFS 752

  Fly   860 VENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLR 924
            |:....|.::.||||..|....||||||.||:.|...:|..||||||.....:||.|::|...|:
  Fly   753 VDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLK 817

  Fly   925 PFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSR 989
            .||||||||::.|:..:||.||:.||..:|....:.||:||||.|....:|.||||||||||:.|
  Fly   818 YFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCR 882

  Fly   990 VPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEE 1054
            ||:.||..|.||.   ||:.|.|........  ||::||||||:|||||::|..|.:|||.|:||
  Fly   883 VPVGGFAELMGSN---GPQRFCIEKVGKETW--LPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE 942

  Fly  1055 TCGFAVE 1061
            |.||..|
  Fly   943 TEGFCQE 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	24/120 (20%)
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736	13/31 (42%)
		WW	562..594	CDD:197736	19/31 (61%)
		HECTc	702..1058	CDD:238033	178/356 (50%)
		HECTc	726..1058	CDD:214523	169/332 (51%)
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	35/179 (20%)
		WW	364..396	CDD:197736	5/47 (11%)
		WW	397..426	CDD:278809	12/28 (43%)
		WW	478..509	CDD:197736	18/30 (60%)
		WW	522..554	CDD:197736	8/60 (13%)
		HECTc	594..946	CDD:238033	178/356 (50%)
		HECTc	620..946	CDD:214523	169/330 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446962
Domainoid	1	1.000	50	1.000	Domainoid score	I3372
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13657at50557
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.780