DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and CG4238

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	116/375 - (30%)
Similarity:	179/375 - (47%)	Gaps:	44/375 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQY 768
            |:|.|.:|.|.|.:.:......|......|.|:||:|:|:||:.|||..|:...:.:.:.|||..
  Fly   615 LKVQREKILESSMKAVKGFSVSDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCT 679

  Fly   769 SRDDHYTLQINPDSGVNPDH--LSYFHFVGRTLGIAVFHGHCLDGG---------FTTPFYKQLL 822
            ..|.|..| ::|:. ..|.|  |.:|.|.|:.:|..:|....  ||         |:..|..||:
  Fly   680 FHDKHQAL-VHPNP-TRPAHLKLKHFEFAGKMVGKCLFESAL--GGTYRQLVRARFSRSFLAQLI 740

  Fly   823 NKPITLGDIEGVDPDLHRS-LTWMLESNISG-------IIESTFSVENNSFGALVVHELKPGGAS 879
            ...:.....|..||||:.| :.::|::::..       .:|..:...:......:  ||.|.||.
  Fly   741 GLRVHYKYFEQDDPDLYLSKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTI--ELIPNGAK 803

  Fly   880 IPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVN 944
            ..||...|.:|:......|....::.:..:..||...:||.:||..|||.||||::.|.....::
  Fly   804 TRVTNATKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSIS 868

  Fly   945 DWRNNTRLKHCTN----ETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGA 1004
            |::.:    |..|    |..:|| |||..|.::|....||||||.||.|::|..||:.|
  Fly   869 DFKAH----HIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQEL------ 923

  Fly  1005 VGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEE 1054
             .|:   ..:||.....|||.||||||::.||.||:|:.....|..|:.|
  Fly   924 -NPQ---FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	116/375 (31%)
		HECTc	726..1058	CDD:214523	110/353 (31%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720
		Filamin	238..336	CDD:279024
		HECTc	615..975	CDD:238033	116/375 (31%)
		HECTc	642..974	CDD:214523	109/348 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840