DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Magix

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001014131.1	Gene:	Magix / 317379	RGDID:	1549729	Length:	326	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	66/284 - (23%)
Similarity:	84/284 - (29%)	Gaps:	112/284 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 TVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD--LGKLSPDDDELVRGQIIISLLSKDGP 141
            |:...|..|:.|...|....|...||: |.:...||.  .|:.|.   |||||.....|....|.
  Rat    86 TLVEHRPQHQRSDTQGPRMEPLPVIQN-KASYASRLPQATGRFSV---ELVRGPAGFGLTLSGGR 146

  Fly   142 S-SGN-PLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVN--------HATKSTQWD 196
            : ||| |||:.|...|  ||::...   .|..|        ..|.|:|        || ::.:|.
  Rat   147 NVSGNVPLAVCGLLKD--GPAQRCG---HLQAG--------DLVLYINGQSTRGLTHA-QAVEWI 197

  Fly   197 RPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRH 261
            |      .|........||....||:   |....|            .||:..|   ...|.|
  Rat   198 R------TGGPRLCLVLQRPQEMNGS---RSKEVG------------GGHQKTD---RIPDPR-- 236

  Fly   262 STEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLH 326
                                                 |||.:|.|.|..|.
  Rat   237 -------------------------------------GGRMMESRGTISPV-------------- 250

  Fly   327 SNDNHVKTPKHQTNGHAPPESTPT 350
               :|  .||.:|.....|||..|
  Rat   251 ---HH--RPKTRTGPGPSPESVAT 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	18/57 (32%)
		WW	169..198	CDD:278809	8/36 (22%)
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
Magix	NP_001014131.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		PDZ_signaling	127..209	CDD:238492	28/104 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..267		22/128 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900