DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Hecw2

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1441 Identity:381/1441 - (26%)
Similarity:557/1441 - (38%) Gaps:466/1441 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RKDLFRLPDPFAKVQVD-----------GTGQVYSTEISKSSLDPKWNAH-YDLFLGIGDAITIT 79
            :|.:|..|||:.|:.:.           ..||...:.|..::.:|.|:.. |..|..:.|.:.|.
  Rat   198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIE 262

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRL--DLGKLSPDDDELVRGQIIISLLSK 138
            :.::    |.|.|  .|||.:.||...:...:..|.|.|  :||:..|.|.  |.|.:...:   
  Rat   263 IKDKFAKSRPIIK--RFLGKLTIPVQRLLERQAVGDQMLSYNLGRRLPADH--VSGYLQFRV--- 320

  Fly   139 DGPSS----------GNPLAIVGPSGDVRGPSEDDS----------------SEDSLPEGWEER- 176
            :.|||          |..|.:...:||:..||:|:.                ||||:.:|..:. 
  Rat   321 EVPSSAQEDASPEAVGTILGVHTVNGDLGSPSDDEDMPGSHHDSTICANGPVSEDSVADGTPKHS 385

  Fly   177 -RTDN--------------------GRVYYVNHATKSTQWDRPRQPGVVGSS------------- 207
             ||.:                    ||...:|....:.:.:.|.:||...||             
  Rat   386 FRTSSTLEIDTEDLISTSSRNSPPRGRQDSLNDYLDAIEHNGPSRPGTASSSERPMGASPKLRSS 450

  Fly   208 -----------HATSPQQRHN----------------------THNGNSGDRQAPAGPTRSTTCT 239
                       |..|.::.|:                      |...:.|...:...|.......
  Rat   451 FPTDTRLNAMLHIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKPEDDNPVE 515

  Fly   240 NLMNNGHRSRDL----------------SVTASDER-----------RHSTEILSSVGKENTSPT 277
            |...:.|.:..|                |.||.||.           :.|||:.||  :|...||
  Rat   516 NEDASVHETASLEERPENLPEVEDGSLPSGTAPDENEASVEPQPSADQGSTELCSS--QEVDQPT 578

  Fly   278 TPVSA---TTTPGKKTSSSNSSS--AGGRTLEQRPTNEPATP--TSSTTSASVRLHSNDNHVKTP 335
            :...|   .|:.|.:.::|.:.|  .|....:.....||:.|  |.|.:.||.|          |
  Rat   579 SGTDAGASDTSVGSRRAASETESLDQGSEPSQVSSETEPSDPARTESVSEASTR----------P 633

  Fly   336 KHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQS-ASNGWTQEDAATTTSPST 399
            :.:::......|...|.|.|.:.|       .|..:....|..|:: |.:...:||.|....| |
  Rat   634 EGESDLEGADSSCNESVTTQLSSV-------ETRCSSLESARFPETPAFSSQEEEDGACAAEP-T 690

  Fly   400 TTSPPRHSQ-SPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRS---QRR 460
            ::.|...|| |..||. |.||...||..             ..|.|:.:...:..|:..   |||
  Rat   691 SSGPTEGSQESVCTPG-SLPAVQVPSRE-------------EEGSGAEATALSEQGELGEVWQRR 741

  Fly   461 SSRQQGEESSTRRRS------------SRGTRNGGTS---GGGGGGGSGQRYASAAIAAANQAAR 510
            .|.:....::|...:            ::|...|.|:   |..||..:.......::.:..|...
  Rat   742 GSLEGAAAAATAAATDSQPQEDGDPGDTQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVS 806

  Fly   511 PF--LD--LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIP------------------------ 547
            .:  :|  |||.:|.|....|::::.......:||..|..|                        
  Rat   807 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQS 871

  Fly   548 ------------------------------RDF-------------------------------- 550
                                          .||                                
  Rat   872 IRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPPVKFLISPEF 936

  Fly   551 -----------------------------DTQHL-----TLDAIG----------PLPSGWEQRK 571
                                         ||.|.     ..|.:|          .||.|||.:.
  Rat   937 FTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKH 1001

  Fly   572 TASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSA----------------------AN 614
            ...|:.:|||||:|||.|.||||.   ||..|     ||||                      .:
  Rat  1002 DHQGKAFFVDHNSRTTTFIDPRLP---LQSSR-----PTSALVHRQHLTRQRSHSAGEVGEDSRH 1058

  Fly   615 AGTPAPPSA-----TPATPSAAAAVP--------------------------------------- 635
            ||.|..|..     |.:.|.....||                                       
  Rat  1059 AGPPVLPRPASTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNILEILQERQPDLARNHSLREKIQF 1123

  Fly   636 --PQATP-----ASNATPTTLTTTTN-------PPHRIV---------------PDLPQGLLEGA 671
              .:.||     :|:|....|.:...       |||.::               |....|.....
  Rat  1124 IRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRAN 1188

  Fly   672 DLLP-KYRRDLVGKLRALRTELQT----MQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKR 730
            ...| .|:||...|||....:|:|    ..|  |..:|.:.|:.:.|:::..||....||: |.:
  Rat  1189 ARAPAPYKRDFEAKLRNFYRKLETKGYGQGP--GKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNK 1251

  Fly   731 LMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFV 795
            |.|.|.|||||||.|.:||:..|:|||:.||.||||:||.:|.||:||:|.|....:|..:|.|.
  Rat  1252 LYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFS 1316

  Fly   796 GRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSV 860
            ||.||:|:.|.:.||..||.||||.||.....|.|:|.:|.:.|:||.||.:::|..|::.||:|
  Rat  1317 GRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTV 1381

  Fly   861 ENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRP 925
            ....||.:...|||||||:|||||:||:||::..|.:|..||:.||..:|.:||.|::.:.|:..
  Rat  1382 NEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1446

  Fly   926 FDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSR 989
            ||.|||||||.|.:.||:|||||||..:...::...|: |||..||.:::|.|.||||||||:|.
  Rat  1447 FDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSS 1511

  Fly   990 VPLQGFRALQGSTGAVGPRLFTIH----LTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQ 1050
            :|.:||.:|:||.   |||.|.:.    :||      ||:|||||||:|||||.::.:|.:||..
  Rat  1512 IPYEGFASLRGSN---GPRRFCVEKWGKITA------LPRAHTCFNRLDLPPYPSFSMLYEKLLT 1567

  Fly  1051 AVEETCGFAVE 1061
            |||||..|.:|
  Rat  1568 AVEETSTFGLE 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 32/125 (26%)
WW 169..198 CDD:278809 6/50 (12%)
WW 514..546 CDD:197736 10/33 (30%)
WW 562..594 CDD:197736 17/31 (55%)
HECTc 702..1058 CDD:238033 172/361 (48%)
HECTc 726..1058 CDD:214523 166/337 (49%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:406866
C2_NEDL1-like 185..321 CDD:176073 32/129 (25%)
MDN1 <396..741 CDD:227596 74/378 (20%)
NESP55 <464..632 CDD:115071 34/169 (20%)
WW 815..844 CDD:395320 8/28 (29%)
HECW1_helix 921..987 CDD:408233 5/65 (8%)
WW 993..1024 CDD:197736 17/30 (57%)
HECTc 1222..1576 CDD:238033 172/362 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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