DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Bag3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	629	Identity:	128/629 - (20%)
Similarity:	192/629 - (30%)	Gaps:	212/629 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SSEDSLPEGWEER-RTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNS--GD 225
            |..|.||.|||.: ....|..::|:|.:::|.|:.||.|       ...|:...::.||.|  |.
Mouse    19 SDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVP-------PEGPKDTASSANGPSRDGS 76

  Fly   226 RQAPAGPTRSTTCTNLMNNGH------RSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATT 284
            |..|            :..||      |...:.:....|           |.||..|.. ..|.:
Mouse    77 RLLP------------IREGHPIYPQLRPGYIPIPVLHE-----------GSENRQPHL-FHAYS 117

  Fly   285 TPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTP 349
            .||                .||...|.|..|...:.:.:|
Mouse   118 QPG----------------VQRFRTEAAAATPQRSQSPLR------------------------- 141

  Fly   350 TSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSA-----SNGWTQEDAATTTSPSTTTSPPRHS-- 407
               .|.......:.|.|......:..||||.:|     |......|.::::|.::..|..|.|
Mouse   142 ---GGMTEAAQTDKQCGQMPATATTAAAQPPTAHGPERSQSPAASDCSSSSSSASLPSSGRSSLG 203

  Fly   408 --QSP----PTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQG 466
              |.|    |.|.|.......|:|..:.|.......||..|    .|      |..|....:.||
Mouse   204 SHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYPAQQG----EY------QPQQPVYHKIQG 258

  Fly   467 EESSTR--RRSS--RGTRNGGTSGGGGGGGSGQR-YASAAIAAANQAARP--------------- 511
            ::...|  |.:|  |....|.:|..|....||.. :..:.|.......||
Mouse   259 DDWEPRPLRAASPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPE 323

  Fly   512 ----------FLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSG 566
                      ..|||||              |||..|       |.|:.|::.::..:  |.|:.
Mouse   324 NKPESKPGPAGPDLPPG--------------HIPIQV-------IRREADSKPVSQKS--PPPAE 365

  Fly   567 WEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAA 631
            ..:.|.:|..:                            ..|..|.|.:..|:||....|...||
Mouse   366 KVEVKVSSAPI----------------------------PCPSPSPAPSAVPSPPKNVAAEQKAA 402

  Fly   632 AAVPPQATPASNATPTTLTTTTNPPH------RIVPDLPQGLLEGADLLPKYRRD---------L 681
                |...||..|.|.:....|.|.|      ..:.:..|||.:..|.....:.|         |
Mouse   403 ----PSPAPAEPAAPKSGEAETPPKHPGVLKVEAILEKVQGLEQAVDSFEGKKTDKKYLMIEEYL 463

  Fly   682 VGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAK 725
            ..:|.|    |.::.|: |...:..:|.:...:...::.|:..|
Mouse   464 TKELLA----LDSVDPE-GRADVRQARRDGVRKVQTILEKLEQK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	10/29 (34%)
		WW	514..546	CDD:197736	9/31 (29%)
		WW	562..594	CDD:197736	4/31 (13%)
		HECTc	702..1058	CDD:238033	3/24 (13%)
		HECTc	726..1058	CDD:214523	128/629 (20%)
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		22/80 (28%)
		WW	23..55	CDD:197736	10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		18/108 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		54/262 (21%)
		BAG	426..503	CDD:214591	14/82 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900