DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1083	Identity:	337/1083 - (31%)
Similarity:	474/1083 - (43%)	Gaps:	296/1083 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 HKGSG------FLGCVRIPAFNI--------------------QSLKG--AGFQRLDLGKL---- 119
            |.|:|      |||.|.:|..::                    :|.|.  .||.||.:..:
  Rat   358 HPGTGVPTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG 422

  Fly   120 ------SPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRT 178
                  |...|::..|..::.                  |.|.....:::.....||.||||:..
  Rat   423 GQDEENSEQRDDMEHGWEVVD------------------SNDSASQHQEELPPPPLPPGWEEKVD 469

  Fly   179 DNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMN 243
            :.||.|||||..:||||.||       |....|.:..:|....|   ::|.....||
  Rat   470 NLGRTYYVNHNNRSTQWHRP-------SLMDVSSESDNNIRQIN---QEAAHRRFRS-------- 516

  Fly   244 NGHRSRDLSVTASDERRHSTEILSSVGKE-NTS--------PTTPVSATTTPGKKTSSSNSSSAG 299
            ..|.|.||...||:......|...::.:| |.:        |..|.|    |..:||....|...
  Rat   517 RRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPAS----PVSRTSPQELSEEL 577

  Fly   300 GRTLEQRPTNE--------PATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQ 356
            .|.|:..|.:.        ...|:|...|.||          |.......|.||.||||.
  Rat   578 SRRLQITPDSNGEQFSALIQREPSSRLRSCSV----------TDTVAEQAHLPPPSTPTR----- 627

  Fly   357 NYVNGNAQNGSTSGNGSGQAAQPQSA--------SNGWTQ-EDAATTT-----SPSTTTSPPRHS 407
                 .|::.:.:|   |:.:.|..|        .:||.: :||...|     :..|||
  Rat   628 -----RARSSTVTG---GEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT------ 678

  Fly   408 QSPPTPNISPPASVTPSANGNVH-------SPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQ 465
            .:.|...::...:...:.|.|.|       .|.:.|:|        :.|.:.|          .:
  Rat   679 WTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSP--------TVTLSAP----------LE 725

  Fly   466 GEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVY 530
            |.:.|..||:.:.|.:...|.......|.:        ..::..:.|  ||||:|||....|:.:
  Rat   726 GAKDSPIRRAVKDTLSNPQSPQPSPYNSPK--------PQHKVTQSF--LPPGWEMRIAPNGRPF 780

  Fly   531 FYHIPTGVSTWHDPRI-------------PRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDH 582
            |....|..:||.|||:             |.|          :||||.|||:|....||.:::||
  Rat   781 FIDHNTKTTTWEDPRLKFPVHMRSKASLNPND----------LGPLPPGWEERIHLDGRTFYIDH 835

  Fly   583 ------------------NNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPS 629
                              :::.||:.||||..                       |....||.|
  Rat   836 SSQVLCGENDTRESVPLYDSKITQWEDPRLQN-----------------------PAITGPAVP- 876

  Fly   630 AAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQT 694
                                                           |.|:...|....|.:|:.
  Rat   877 -----------------------------------------------YSREFKQKYDYFRKKLKK 894

  Fly   695 MQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRK-RLMVKFKGEEGLDYGGVAREWLHLLSREM 758
            .........:::.||.|||||||.||.::..|:.| ||.::|:.|:|||||||||||..|||:||
  Rat   895 PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEM 959

  Fly   759 LNPQYGLFQYSRDDHYTLQINPDSGV-NPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLL 822
            .||.||||:||..|:|||||||:||: |.||||||.|:||..|:|||||..|||.|..||||.:|
  Rat   960 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 1024

  Fly   823 NKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENK 887
            .|.|||.|:|.||.:.:.||.|:||::.:. ::..|.::..:||.....:|||.|:.|.||.|||
  Rat  1025 GKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENK 1088

  Fly   888 REYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRL 952
            |||:.|.:.:||:..:::|..|..:||.||:|..|::.|||.||||::.|:..:||||||.::..
  Rat  1089 REYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIY 1153

  Fly   953 K--HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLT 1015
            |  :|.|... :.|||:.|....:|.|.||||||||:||||:.||..|.||.   ||:||||...
  Rat  1154 KNGYCPNHPV-IQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQLFTIEQW 1214

  Fly  1016 ADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ..  .:.||:|||||||:|||||||::.|.:||..|||...||
  Rat  1215 GS--PEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	17/85 (20%)
		WW	169..198	CDD:278809	17/28 (61%)
		WW	514..546	CDD:197736	14/31 (45%)
		WW	562..594	CDD:197736	15/49 (31%)
		HECTc	702..1058	CDD:238033	184/359 (51%)
		HECTc	726..1058	CDD:214523	173/335 (52%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471	11/52 (21%)
		WW	463..489	CDD:395320	15/25 (60%)
		WW	653..682	CDD:395320	8/34 (24%)
		WW	766..796	CDD:238122	13/29 (45%)
		WW	815..865	CDD:197736	15/49 (31%)
		HECTc	926..1255	CDD:214523	173/335 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710