DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smurf and Hecw1

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:XP_017455974.1 Gene:Hecw1 / 291209 RGDID:1561038 Length:1603 Species:Rattus norvegicus


Alignment Length:1424 Identity:380/1424 - (26%)
Similarity:545/1424 - (38%) Gaps:428/1424 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RKDLFRLPDPFAKVQVD-----------GTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:.           ..||...:.|..::::|.|.|.:..|:.: .|.:.|.
  Rat   219 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSTIIGNTVNPIWQAEHFSFVSLPTDVLEIE 283

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD--LGKLSP----------------- 121
            |.::    |.|.|  .|||.:.:|...:......|.:.:.  ||:..|                 
  Rat   284 VKDKFAKSRPIIK--RFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGHLQFRFEITSS 346

  Fly   122 ---DDDEL----------VRGQIIISLLSKDGPSSGNPLAIVGPSGDV---------RGPSEDDS 164
               ||:|:          |:..::.|::..   |||.      |.||.         ..|||:|.
  Rat   347 IHADDEEISLNAEPESAEVQDSVMNSVVEN---SSGE------PPGDAAEFLKDLKPEAPSEEDG 402

  Fly   165 SEDSLPEGWEERRTDNGRVYYVNHA--TKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQ 227
            ...|..|..|..|.       |..|  ...|:.|.....|.........|:| |:|....|.:..
  Rat   403 VRGSENENREHARP-------VEEAAGAMETRDDSKFSEGPEEVGELQDPEQ-HDTQPTLSAEEV 459

  Fly   228 A---PAG--------PTRSTTCTN------LMNNGHRSRDLSVTASDERRH-----------STE 264
            |   |.|        |..||...:      :..||....::.....||...           ..|
  Rat   460 AERLPLGEGCPPSLLPEESTALGSKAEEEAIPENGAGEEEMQEKGKDEEEEEGVSALEQGEPGLE 524

  Fly   265 ILSSVGKENTSPTTPVSATTTP-----GKKTS-------------SSNSSSAGGRTLEQRPTNEP 311
            :.:||.|::...:.|||...|.     |:..:             |..|:..|..|.|:....|.
  Rat   525 LRASVRKKSRPCSLPVSELETVIASACGEAETPRTHYIRIHTLLHSMPSAQRGSTTEEEDAMEEE 589

  Fly   312 ATPTSST-----------------------TSASVRLHSND-------NHVKTPKHQTNGHAPPE 346
            :|...|:                       ..|::.:.|:|       |..|:.....:|.|.|.
  Rat   590 STLKESSEKDGLSEVDTIAADPQSMEDGENNGATLCMASSDCSGGHFSNLSKSIGAGQDGEAHPS 654

  Fly   347 STPTSPTGQQ-------------------------------------NYVNGNAQNGSTSGNGSG 374
            :...|.:..|                                     :..|||.:..|.:...|.
  Rat   655 TGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSSSCYNGNNRFASHTRFSSV 719

  Fly   375 QAAQ-----------------------PQS---------ASNG---WTQE------DAATTT--- 395
            .:|:                       |.|         ::||   |..|      :||.||   
  Rat   720 DSAKISESTVFSSQEDEEEENSAFESVPDSVQSPELDPESTNGAGPWQDELAAPGGNAARTTEGL 784

  Fly   396 -SPSTTTSPPRHSQSPPTPNISPPASVTPS------------------------ANGNV------ 429
             ||....|..|....|...| |.|.|..||                        ::|.|      
  Rat   785 DSPMAGPSNRREGDCPMLHN-SQPISQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHV 848

  Fly   430 ------HSPNANSTPAG---SGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTS 485
                  ..|:...||.|   ||...:........|..||..:.::.||.|           |..|
  Rat   849 NRTTTWQRPSMAPTPDGMIRSGSVHQMEQLNRRYQNIQRTIATERSEEDS-----------GNQS 902

  Fly   486 ------GGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTT---QQGQVYFYHIPTGVSTW 541
                  ||.|||||.   :.|..:.:|...|....|.|....:.|   |...|.|...|...:..
  Rat   903 CEQIPDGGAGGGGSD---SEAESSQSNLDLRREGSLSPVNSQKVTLLLQSPAVKFITNPEFFTVL 964

  Fly   542 HD---------------------PRIPRDFDTQHLTLDAIG----------PLPSGWEQRKTASG 575
            |.                     .|..|:|:......|.:.          .||.|||.:....|
  Rat   965 HANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQG 1029

  Fly   576 RVYFVDHNNRTTQFTDPRL---SGSI---------LQMIRRGTVPPTSAANAGTPAPPSATPATP 628
            :.:|||||:|.|.|.|||:   :|.:         ||.:|..:....|..:....|...|.|...
  Rat  1030 KSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHS 1094

  Fly   629 SAAA--------AVP----------------------PQATPASNAT------------------ 645
            ..||        ::|                      .|.:.|.|.|                  
  Rat  1095 LIAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEK 1159

  Fly   646 --------------------PTTLTTTTNPPHRIVP-----DLPQ---GLLEGADLLPK-YRRDL 681
                                ...|.:..:|.:...|     ..||   ||...:...|. ||||.
  Rat  1160 LSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDF 1224

  Fly   682 VGKLRAL--RTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDY 743
            ..|||..  :.|.:......|..:|.:.|:.:.|.::..:|....|:: |.:|.:.|.|||||||
  Rat  1225 EAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDY 1289

  Fly   744 GGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHC 808
            .|.:||:..|||:|:.||.||||:||.:|.||:||:|.|....::|.:|.|.||.||:|:.|.:.
  Rat  1290 SGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQYL 1354

  Fly   809 LDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHEL 873
            ||..||.||||.||..|..|.|:|.:|.:.|:||.||.::||:.|::.||:|....||.:...||
  Rat  1355 LDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTEREL 1419

  Fly   874 KPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGI 938
            |.|||:..|||:||:||::..|.:|..||:.||..||.:||.|::.|.|:..||.|||||||.|.
  Rat  1420 KSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGT 1484

  Fly   939 SSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGST 1002
            :.||:|||||||..:...::...|: |||..||.:::|.|.||||||||:|.||.:||.||:||.
  Rat  1485 AEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSN 1549

  Fly  1003 GAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            |.   |.|.|.....:  .:||:|||||||:|||||.:|..|.:||..|||||..|.:|
  Rat  1550 GL---RRFCIEKWGKI--TSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTFGLE 1603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 31/155 (20%)
WW 169..198 CDD:278809 7/30 (23%)
WW 514..546 CDD:197736 8/55 (15%)
WW 562..594 CDD:197736 16/31 (52%)
HECTc 702..1058 CDD:238033 171/357 (48%)
HECTc 726..1058 CDD:214523 166/333 (50%)
Hecw1XP_017455974.1 HECW_N 66..185 CDD:293170
C2_NEDL1-like 206..342 CDD:176073 27/124 (22%)
WW 827..857 CDD:197736 2/29 (7%)
WW 1017..1048 CDD:197736 16/30 (53%)
HECTc 1247..1601 CDD:238033 171/358 (48%)
HECTc 1271..1600 CDD:214523 166/333 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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