DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and HECTD1

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:1420 Identity:274/1420 - (19%)
Similarity:436/1420 - (30%) Gaps:537/1420 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 LGKLSPDDD-------ELVRGQIIISLL--------------SKDGPSSGNPLAIVGPSGDVRGP 159
            |||.:.:.:       .|||.|::..::              .:||...|        .|.|.| 
Human  1248 LGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQG--------EGTVTG- 1303

  Fly   160 SEDDSSEDSLPEGWEERRTDNG--RVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNG- 221
                    .|..||.:...|.|  ..|.:....|   :|....||....:.| ||:...:|.:| 
Human  1304 --------ELHNGWIDVTWDAGGSNSYRMGAEGK---FDLKLAPGYDPDTVA-SPKPVSSTVSGT 1356

  Fly   222 ----------NSGDR-QAPAGPTRSTTCTNLMNNGHRSRDLSV-TASDERR------HS------ 262
                      |..|: .|.||.:.....::.:.:...|.|:|: :...|||      ||      
Human  1357 TQSWSSLVKNNCPDKTSAAAGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGAD 1421

  Fly   263 ----TEILSS--------VGKENTSPTTPVSATT----------------TPGKKTSSS----NS 295
                ..:|||        ||..:::.|:.::|.|                |||:.::.|    :.
Human  1422 VHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSV 1486

  Fly   296 SSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVN 360
            ||....::.:....|.|:....::|||.|| |..:.:......::..:.|..:....:..:::|.
Human  1487 SSPDVSSVSELTNKEAASQRPLSSSASNRL-SVSSLLAAGAPMSSSASVPNLSSRETSSLESFVR 1550

  Fly   361 GNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTT----SPSTTTSPPRHSQSPPTPNISPP--- 418
            ..|....|:...:...::..|.:|        |.|    ..||.|||...:||  .||::.|   
Human  1551 RVANIARTNATNNMNLSRSSSDNN--------TNTLGRNVMSTATSPLMGAQS--FPNLTTPGTT 1605

  Fly   419 ASVTPSANGNVHSPN-ANSTPAGSGGGSRSYTAAT----------PGQRSQ----------RRSS 462
            ::||.|.:....|.| |.:|...|.|.|.|.|..|          .||.::          |.|:
Human  1606 STVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRAST 1670

  Fly   463 ---------------------------RQQGEESSTRRRSSRGTRNGGTS--------------- 485
                                       .|:.||....||.|...|.|..|               
Human  1671 LLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVP 1735

  Fly   486 GGGGGGGSGQ-----------------------RYASAAIAA-------ANQAARPFLDLPPG-- 518
            .|.|....|:                       |..||.:.|       .|......|::||.  
Human  1736 AGAGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT 1800

  Fly   519 ------YEMRTTQQGQVYFYHIPTGVSTWHDPRIPRD--------FDTQHLTLDAIGPLPSG--- 566
                  .|:..|...::......||:.|..:..:|..        :..:.|.|...|.:.|.   
Human  1801 PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKSDKLR 1865

  Fly   567 --WE-------------QRKTASGRV--------------------------------YFVDHNN 584
              ||             .::..:|::                                .|:.|..
Human  1866 RIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWK 1930

  Fly   585 RTTQFTDPRLSGSILQMI-------RRGTVPPTSAANAG-------------TPAPPSATPATPS 629
            .|......|.:.:..|:|       ..||   .|..|.|             |...|.|......
Human  1931 LTGTNKSIRKNRNCSQLIAAYKDFCEHGT---KSGLNQGAISTLQSSDILNLTKEQPQAKAGNGQ 1992

  Fly   630 AAAAV----------------------------PPQAT-PASNATPTTLTTTTNPPHRIVPDLPQ 665
            .:..|                            .||.| |....|...:||      :|:..:.:
Human  1993 NSCGVEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITT------KILQQIEE 2051

  Fly   666 GLLEGADLLPKYRRDLVGKL---------------------RAL--------------RTELQTM 695
            .|...:..||.:...|..|.                     ||:              ||.....
Human  2052 PLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVR 2116

  Fly   696 QPQSG--------HCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLH 752
            :...|        |.|::|.|.|...|....:|::.| |.:..|.|:|.||||...|... |:..
Human  2117 RDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHA-DRKSVLEVEFLGEEGTGLGPTL-EFYA 2179

  Fly   753 LLSREMLNPQYGLFQYSRDDHY----TLQINPDSGVNP--------------------DHL---- 789
            |::.|......|  .:..||::    :..::...|:.|                    |.|    
Human  2180 LVAAEFQRTDLG--AWLCDDNFPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERIT 2242

  Fly   790 SYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEG----------VDPDLHRS--- 841
            ..|||:|..|...:.....:|...:.||:|.:     .:|||:.          .|.|||.:   
Human  2243 KLFHFLGIFLAKCIQDNRLVDLPISKPFFKLM-----CMGDIKSNMSKLIYESRGDRDLHCTESQ 2302

  Fly   842 -----------------------------------------LTW--------------------- 844
                                                     |||                     
Human  2303 SEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLA 2367

  Fly   845 -----------------------MLESNISGI----------IESTFSVENNSFGALVVHELKPG 876
                                   ::..|.||.          :...|...:..:|...| :|||.
Human  2368 IKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAV-DLKPS 2431

  Fly   877 GASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSI 941
            |....:|.:|..|||.|..::....||::|..|.:.||.::.|...|..|...|:::::.|..|.
Human  2432 GEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSP 2496

  Fly   942 D--VNDWRNNTRLK-HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTG 1003
            .  ..|..|.|..| ..|.::...|.|.:|:...||:.|...|||.||.|.:|..|...|.    
Human  2497 SWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLH---- 2557

  Fly  1004 AVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
               ||| |:....|....:.|..:||.:.:.||.|.:.:::.::|..|..|. ||
Human  2558 ---PRL-TVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEK-GF 2607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 7/25 (28%)
WW 169..198 CDD:278809 8/30 (27%)
WW 514..546 CDD:197736 7/39 (18%)
WW 562..594 CDD:197736 7/81 (9%)
HECTc 702..1058 CDD:238033 107/494 (22%)
HECTc 726..1058 CDD:214523 100/470 (21%)
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269
Ank_2 366..457 CDD:403870
ANK repeat 366..393 CDD:293786
ANK 1 395..424
ANK repeat 396..426 CDD:293786
ANK 2 426..455
ANK repeat 428..457 CDD:293786
ANK 3 459..491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513
ANK 4 579..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748
Sad1_UNC 1107..1240 CDD:400199
MIB_HERC2 1277..1335 CDD:399589 14/77 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 13/63 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 9/49 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 12/82 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 3/19 (16%)
BTHB 1892..1965 CDD:408209 9/75 (12%)
K-box 2029..2103 13/79 (16%)
HECTc 2131..2608 CDD:238033 109/496 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 1/20 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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