DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and pub3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_595793.1	Gene:	pub3 / 2539956	PomBaseID:	SPBC16E9.11c	Length:	786	Species:	Schizosaccharomyces pombe

Alignment Length:	1071	Identity:	340/1071 - (31%)
Similarity:	487/1071 - (45%)	Gaps:	308/1071 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDA 75
            |..:||..|:.|..|:::||||.|||||.:.|||. |.::|::.|.|::|.||..:::.:.....
pombe     4 GAKRVRFYIVAADGLSKRDLFRQPDPFAILTVDGE-QTHTTKVIKKSVNPYWNEGFEVTVKPSSV 67

  Fly    76 ITITVWNQRKI-HKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISL---L 136
            |:|.:::|:|. .|..||||.|             .|:..::|..        |....:||   |
pombe    68 ISIRLFDQKKFKKKDQGFLGLV-------------SFRMREVGSF--------RSNREVSLTRPL 111

  Fly   137 SKDGPSS----GNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDR 197
            .|...::    ||.:..|.|| .:|.|:.:.||..:       .||.:.........|::|
pombe   112 KKSSTTNLSVLGNLVLKVAPS-KIRAPAGNHSSTTA-------NRTTSTPTTTTARTTRTT---- 164

  Fly   198 PRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHS 262
            ||                                ||.:|..:|            .:.|:..|:.
pombe   165 PR--------------------------------PTATTNTSN------------QSTSNSTRNG 185

  Fly   263 TEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHS 327
            |                 ||.|:.|..|.:...:|.....:..|.||        .|||   |.:
pombe   186 T-----------------SAATSNGTGTGAGTGASHRSSPVTNRQTN--------NTSA---LSN 222

  Fly   328 NDNHVKTPKHQTNGHAPP--ESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQED 390
            ::.|:.:......|..||  |....| .|:..||:.|.:
pombe   223 SNAHIMSSFEDQYGRLPPGWERRADS-LGRTYYVDHNTR-------------------------- 260

  Fly   391 AATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQ 455
            ..|.|.|:::|:|                         ||:.:::|                  |
pombe   261 TTTWTRPASSTNP-------------------------VHNTSSDS------------------Q 282

  Fly   456 RSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYE 520
            |...::.....:.:.:..:|..|.                                  |||.|:|
pombe   283 RLNHQNRHLPDDSNPSLMQSDSGN----------------------------------DLPFGWE 313

  Fly   521 MRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDT----------QHLTLDAIGPLPSGWEQRKTASG 575
            ||.|..|:.||....|..:||.|||.|.....          |..:|..:||||||||.|.|.|.
pombe   314 MRYTDTGRPYFVDHNTRTTTWVDPRNPLVRPNGGSSTVGSLMQPQSLSHLGPLPSGWEMRLTNSA 378

  Fly   576 RVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATP 640
            ||||||||.:||.:.||||                                 |||
pombe   379 RVYFVDHNTKTTTWDDPRL---------------------------------PSA---------- 400

  Fly   641 ASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLE 705
                              :..|:||           |:.|...||...|:: ..|:|..|.|.::
pombe   401 ------------------LDQDVPQ-----------YKCDFRRKLIYFRSQ-PGMRPLPGQCNVK 435

  Fly   706 VSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSR 770
            |.|:.|||:||..||:..|.|::||||::|.||:||||||::||:..|||.:|.:|.|.||:||.
pombe   436 VRRDHIFEDSYAEIMRYSAHDLKKRLMIRFDGEDGLDYGGLSREFFFLLSHKMFDPIYCLFEYSA 500

  Fly   771 DDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVD 835
            .|:|||||||.|.:||:||:||.|:||.:|:|:||...||..|....||:||.|.::|.|:|.:|
pombe   501 VDNYTLQINPHSSINPEHLNYFRFIGRVIGLAIFHRRFLDAFFVVSLYKKLLRKKVSLADMESID 565

  Fly   836 PDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFM 900
            .:.:|||.|:||::|:||::.|||||.:.||.:...||...|.:|.||||||::||.|...:|..
pombe   566 AEFYRSLKWVLENDITGILDLTFSVEEDHFGEVRTVELITNGENIEVTEENKKKYVDLVTEWRVS 630

  Fly   901 RGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWF 965
            :.:||||.|...||.||:...|:..||||||||:|||||.:||.||:::|..:........:.||
pombe   631 KRVEQQFNAFYSGFVELVSPDLVNVFDERELELLIGGISDVDVEDWKSHTEYRTYIATDPVIKWF 695

  Fly   966 WQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCF 1030
            |:::..:.:|.|::||||.||:||:|:.|||.||||.   |||.|||. .|..|.| ||.|||||
pombe   696 WEIIAGWKNEDRSKLLQFATGTSRIPVNGFRDLQGSD---GPRKFTIE-KAGTPDQ-LPVAHTCF 755

  Fly  1031 NRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            ||:|||.|.:...|.:||:.|||.|.||..|
pombe   756 NRLDLPDYPSKDTLHEKLSLAVENTVGFGNE 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	37/121 (31%)
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736	16/31 (52%)
		WW	562..594	CDD:197736	22/31 (71%)
		HECTc	702..1058	CDD:238033	179/355 (50%)
		HECTc	726..1058	CDD:214523	168/331 (51%)
pub3	NP_595793.1	HUL4	4..786	CDD:227354	339/1069 (32%)
		C2_Smurf-like	7..130	CDD:176028	43/144 (30%)
		WW	238..267	CDD:278809	10/55 (18%)
		WW	308..337	CDD:278809	13/28 (46%)
		WW	365..397	CDD:197736	22/31 (71%)
		HECTc	434..784	CDD:238033	179/354 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2674
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2041
TreeFam	0	0.000	Not matched by this tool.
	7	6.810