DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Plekha7

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	1062	Identity:	208/1062 - (19%)
Similarity:	333/1062 - (31%)	Gaps:	335/1062 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVG 205
            |.:|.|:    .||.:        ....||.||||..|:.|..::::|..::|.:..|    |.|
Mouse    39 PRTGEPV----NSGHM--------IRSDLPRGWEEGFTEEGASFFIDHNQQTTTFRHP----VTG 87

  Fly   206 S---------------SHATSPQQRHNTHN--------GNSGDRQAPAGPTRSTTCTNLMNNGHR 247
            .               .|.:.|::.....:        |.:...:|..||....:.:.:.:.|.|
Mouse    88 QFSSENSEYVLREEPHPHMSKPERNQRPSSMVSETSTAGTTSTLEAKPGPKIVKSSSKVHSFGKR 152

  Fly   248 S----RDLSVTA--------------------------------SDERRHSTEILSSVGKEN--T 274
            .    |:|:|..                                .|.|..:  :|.|:...:  .
Mouse   153 DQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEA--VLGSIPLPSYVI 215

  Fly   275 SPTTP--------------------VSATTTPGKKTSSSNSSS--AGGRTLEQ-----RPTNEPA 312
            ||..|                    :.:|||.|.:...|...:  ....|||.     |..|:.|
Mouse   216 SPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEHSGMRTYYFSADTLEDMNAWVRAMNQAA 280

  Fly   313 TPTSSTT------SASVRLHSNDNHVKTPKHQTNGHAPPESTPTSP-TGQQNYVNGN-------- 362
            ...|.::      ....:.....||  |...|..||..|..:...| .|.::....|
Mouse   281 QVLSRSSLRRDVDKVERQAMPQANH--TDACQECGHVGPGHSRDCPRRGYEDSYGFNRREQEEER 343

  Fly   363 --AQNGSTSG-NGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPP---TPNISPPASV 421
              ||.....| ....:|..|...:    :|||.....|    ..||..|:.|   ..|..||..:
Mouse   344 FRAQRDPLEGRRDRSKARSPYLPA----EEDALFVDLP----GGPRGQQAQPQRAEKNGVPPYGL 400

  Fly   422 TPSANGNVHSPNANSTPAGSGGGSRSY--TA---ATPGQRSQRRSSRQQGEESSTRRRSSRGTRN 481
                              |...|:..|  ||   |.|.:.|||::...|.|..:..::
Mouse   401 ------------------GEQNGTNGYQRTAPPRANPEKHSQRKTGLAQAEHWTKAQK------- 440

  Fly   482 GGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEM--RTTQQGQVYFYHIPTGVSTWHDP 544
                      |.|:.............::| |..|..|:.  ::|:       |: :|.|:....
Mouse   441 ----------GDGRSLPLDQTLPRQGPSQP-LSFPENYQSLPKSTR-------HL-SGSSSPPPR 486

  Fly   545 RIPRDFD-----TQHLTLDAIGPLPSGWEQRKTASGRVYFV---------DHNNRTT-------Q 588
            .:|.|:.     ..||.:       |..|:|....|.|:.:         .|.:.|.       :
Mouse   487 NLPSDYKYAQDRASHLKM-------SSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPE 544

  Fly   589 FTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTT 653
            ||:...|.|:|::.|..:||| |.::...|.||...|              |....||....|..
Mouse   545 FTEQGRSRSLLEVPRSISVPP-SPSDIPPPGPPRPFP--------------PRRPHTPAERVTVK 594

  Fly   654 NPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVS----RNEIFEE 714
            .|..|...|:..|   |:   |:..|....| .:...:.::| |..|:....||    ..:..||
Mouse   595 PPEQRRSVDISLG---GS---PRKARGHAAK-NSSHVDRRSM-PSMGYMTHTVSAPSLHGKSLEE 651

  Fly   715 SYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQIN 779
            ...|:.:::....:...:..|          ...:.||         .|..|...:.|...||:.
Mouse   652 LSLLLTRLQRHQSKLASVRNF----------AVGQLLH---------HYLTFPACQADDTYLQLK 697

  Fly   780 PDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLG-----DIEGVDPDLH 839
            .|       |.|       |.:.:.:...|    ....||.|  |....|     .:.|.|....
Mouse   698 KD-------LEY-------LDLKIKNNEPL----INVLYKVL--KKSARGCRPGRSMTGRDLLKD 742

  Fly   840 RSLTWMLESNISGIIESTFSVENNSF--GALVVHELKPGGASIPVTEENKREYVK-LYVNYRFMR 901
            |||..|      .|.||...|:.:.|  ...::.:|:.   .|...:|||.:... |.|.:|...
Mouse   743 RSLKPM------KIAESDIDVKLSIFCEQDRILQDLED---KIRALKENKDQLESVLEVLHRQTE 798

  Fly   902 GIEQQFLALQKGFCEL---------IPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTN 957
            ....|...|:|..|:.         |.:.|.|...|.|             |.|....:|:....
Mouse   799 QYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEME-------------NAWNEYLKLEKDVE 850

  Fly   958 ETTQVL-------WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLT 1015
            :..|.|       :|:|.......:: .|:...:.|.| ...:.:|.|.||  ...|...|:.|
Mouse   851 QLKQTLQEQHRRAFFFQEKSQIQKDL-WRIEDVMAGLS-ANKENYRVLVGS--VKNPERKTVPL- 910

  Fly  1016 ADVPTQNLPKAHTCFNRIDLPP 1037
              .|..::|......::..|.|
Mouse   911 --FPHPSVPSLSPTESKPALQP 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	10/28 (36%)
		WW	514..546	CDD:197736	6/33 (18%)
		WW	562..594	CDD:197736	9/47 (19%)
		HECTc	702..1058	CDD:238033	72/364 (20%)
		HECTc	726..1058	CDD:214523	67/336 (20%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073	208/1062 (20%)
		WW	55..84	CDD:366073	10/28 (36%)
		PH_PEPP1_2_3	158..280	CDD:270068	20/123 (16%)
		Smc	<692..>894	CDD:224117	50/245 (20%)
		PHA03247	<903..1009	CDD:223021	7/31 (23%)
		PRK10263	<912..>1118	CDD:236669	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900