Protein Alignment Smurf and WWC1

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_011532787.1
• Gene: WWC1 / 23286
• HGNCID: 29435
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 89/410 - (21%)
• Similarity: 138/410 - (33%)
• Gaps: 126/410 - (30%)

  Fly   510 RPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTL-DAIG-PLPSGWEQRKT 572
            ||.|.||.|:|......|:||:.......::|.|   |||..|:.||. |.|. .||.|||:...
Human     3 RPELPLPEGWEEARDFDGKVYYIDHTNRTTSWID---PRDRYTKPLTFADCISDELPLGWEEAYD 64

  Fly   573 ASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQ 637
            .....||:|||.:|||..|||:
Human    65 PQVGDYFIDHNTKTTQIEDPRV------------------------------------------- 86

  Fly   638 ATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHC 702
                                       |...|...:|..|   ||....||..:.:..|
Human    87 ---------------------------QWRREQEHMLKDY---LVVAQEALSAQKEIYQ------ 115

  Fly   703 RLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYG--------GVAREWLHLLSREML 759
             ::..|.|:.::.|:.:..:....:..::.:.........|.        ..|:..::.|.|||:
Human   116 -VKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMV 179

  Fly   760 NPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNK 824
            :.|:.| |:......||: ..|..::....||                .||.........:.:.|
Human   180 HLQHEL-QFKERGFQTLK-KIDKKMSDAQGSY----------------KLDEAQAVLRETKAIKK 226

  Fly   825 PITLGDIEGVDPDLHRSLTWMLESNI-------SGIIESTFSVENNSFGA----LVVHELKPGGA 878
            .||.|:.|  ..||.:||. ||:...       |.:..|:.|:|::||..    |.|........
Human   227 AITCGEKE--KQDLIKSLA-MLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISG 288

  Fly   879 SIPVTEENK-REYVKLYVNY 897
            |..:...|: .|.|:|.:.|
Human   289 SFGINSNNQLAEKVRLRLRY 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/31 (29%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033	44/216 (20%)
		HECTc	726..1058	CDD:214523	41/192 (21%)
WWC1	XP_011532787.1	WW	9..39	CDD:238122	9/32 (28%)
		WW	55..84	CDD:278809	13/28 (46%)
		ALDH-SF	429..>481	CDD:299846
		C2_Kibra	721..844	CDD:176062

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900