Protein Alignment Smurf and HECW1

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_016867371.1
• Gene: HECW1 / 23072
• HGNCID: 22195
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 1425
• Identity: 376/1425 - (26%)
• Similarity: 541/1425 - (37%)
• Gaps: 425/1425 - (29%)

  Fly    27 RKDLFRLPDPFAKVQVD-----------GTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:.           ..||...::|..::::|.|.|....|:.: .|.:.|.
Human   250 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIE 314

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD--LGK-------------------- 118
            |.::    |.|.|  .|||.:.:|...:......|.:.:.  ||:
Human   315 VKDKFAKSRPIIK--RFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSS 377

  Fly   119 LSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSE-DDSSEDSLPEGWEERRTDNGR 182
            :.|.|||    :|.:|...:......:|:..:..||.....|| .:|||...||...|....:|
Human   378 IHPADDE----EISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDG- 437

  Fly   183 VYYVNHATKSTQWDRPRQPGVV---------------GSSHATSPQQR------------HNTHN 220
                 ...:|.:..||.:...|               |:....:..|:            .....
Human   438 -----PGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDL 497

  Fly   221 GNSG------DRQAPAGPTRSTTCTNLMNNGHRSR-----------DLSVTASDERRHSTEILSS 268
            |...      |.:|||..................|           |:|.....|.|  .::.:|
Human   498 GEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGR--LQLRAS 560

  Fly   269 VGKENTSPTTPVSATTT--------PGKKTS---------SSNSSSAGGRTLEQRPTNEPATPTS 316
            |.:::...:.|||...|        |....:         .|..|:.||...|:....|..: |.
Human   561 VKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEES-TL 624

  Fly   317 STTSASVRLHSNDNHVKTPKHQTNGHAPPE-STP-TSPTGQQ-----NYVNGNAQNGST-SGNGS 373
            ..:|....|...|.....|.........|| :|| |:..|..     :..||.||:|.| ...||
Human   625 KDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGS 689

  Fly   374 GQAAQPQ---------------------------------------------------------- 380
            ...:.|:
Human   690 ESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSS 754

  Fly   381 ------------SASNGWTQEDAATTTSPSTTTSP---------------------------PRH 406
                        |:.:...:|::|..:.|.:..||                           |..
Human   755 VDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEG 819

  Fly   407 SQSP------------PTPNISPPASVTPSANGNVH---------SPN----------------A 434
            .:||            |..:.|.|.|..||.....|         .||                .
Human   820 LESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHV 884

  Fly   435 NSTPAGSGGGSRSYTAATP-GQRSQRRSSRQQGEESSTRRR-------SSRGTRNGGT------- 484
            |.|..    ..|...|||| |.|  |..|.||.|:.:.|.:       :.|...:.|:
Human   885 NRTTT----WQRPTAAATPDGMR--RSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAP 943

  Fly   485 SGGGGGGGSGQRYASAAIAAANQAARPFLD------LPPGYEMRTT---QQGQVYFYHIPTGVST 540
            :||||||||...      |.::|::   ||      |.|....:.|   |...|.|...|...:.
Human   944 AGGGGGGGSDSE------AESSQSS---LDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTV 999

  Fly   541 WHD---------------------PRIPRDFDTQHLTLDAIG----------PLPSGWEQRKTAS 574
            .|.                     .|..|:|:......|.:.          .||.|||.:....
Human  1000 LHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQ 1064

  Fly   575 GRVYFVDHNNRTTQFTDPRL---SGSI---------LQMIRRGTVPPTSAANAGTPAPPSATPAT 627
            |:.:|||||:|.|.|.|||:   :|.:         ||.:|..:....|..:....|...|.|..
Human  1065 GKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGH 1129

  Fly   628 PSAAA--------AVP----------------------PQATPASNAT----------------- 645
            ...||        ::|                      .|.:.|.|.|
Human  1130 SLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLE 1194

  Fly   646 ---------------------PTTLTTTTNPPHRIVP-----DLPQ---GLLEGADLLPK-YRRD 680
                                 ...|....:|.:...|     ..||   ||...:...|. ||||
Human  1195 KLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRD 1259

  Fly   681 LVGKLRAL--RTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLD 742
            ...|||..  :.|.:......|..:|.:.|:.:.|.::..:|....|:: |.:|.|.|.||||||
Human  1260 FEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLD 1324

  Fly   743 YGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGH 807
            |.|.:||:..|||:|:.||.||||:||.:|.||:||:|.|....:||.:|.|.||.||:|:.|.:
Human  1325 YSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY 1389

  Fly   808 CLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHE 872
            .||..||.||||.||..|..|.|:|.:|.:.|:||.||.::||:.|::.||:|....||.:...|
Human  1390 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERE 1454

  Fly   873 LKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGG 937
            ||.|||:..|||:||:||::..|.:|..||:.||..||.:||.|::.|.|:..||.|||||||.|
Human  1455 LKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAG 1519

  Fly   938 ISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGS 1001
            .:.||:|||||||..:...::...|: |||..||.:::|.|.||||||||:|.||.:||.||:||
Human  1520 TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGS 1584

  Fly  1002 TGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            .|.   |.|.|.....:  .:||:|||||||:|||||.:|.:|.:||..|||||..|.:|
Human  1585 NGL---RRFCIEKWGKI--TSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	31/145 (21%)
		WW	169..198	CDD:278809	5/28 (18%)
		WW	514..546	CDD:197736	9/61 (15%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	173/357 (48%)
		HECTc	726..1058	CDD:214523	168/333 (50%)
HECW1	XP_016867371.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810