DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Hectd2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001156943.1	Gene:	Hectd2 / 226098	MGIID:	2442663	Length:	775	Species:	Mus musculus

Alignment Length:	818	Identity:	202/818 - (24%)
Similarity:	309/818 - (37%)	Gaps:	248/818 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 SGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQ-----RYASA 500
            |.|...:..||.|.:|..:...|::.....|          .|.:.|...|..||     .:.|.
Mouse     9 SPGAPPAVAAAAPEERKGKEPEREKLPPIVT----------AGAAAGLDRGSKGQISTFSSFVST 63

  Fly   501 AI----AAANQAA---------RPFLDLPP-GYEMRTTQQGQVYFYHIPTGVSTWHDPRIP---- 547
            ..    ||.|:::         |...|||| ..::|..|:..|........|....:|.:|
Mouse    64 VTQKKEAAENRSSPTHLALPNIRNVRDLPPICLDVRQKQRMSVEALPSEVKVPPLPEPSLPSQPK 128

  Fly   548 --RDFD-------------TQH----LTLDAIGPLPSGWEQRKTASG------------------ 575
              :||:             |.|    ...|:...|.:.:::..|||.
Mouse   129 TVKDFEEDLEKAEATGNWKTVHAFYITAFDSFTELNTAFKKDATASFNTIEDSGLNANLVNAVFD 193

  Fly   576 ----------------------------------RVYFV-------------------------- 580
                                              |.||:
Mouse   194 ALLNTPQDIQKSVLKGIINSLLQEWKGPRTKDDLRAYFILLQNPQFNITSTYVIYAHLLRQIATL 258

  Fly   581 ---DHN------NRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPAT---PSAAAA 633
               ||:      .:.:|....:|...:||.:.....|      |.....|..|..|   ||||..
Mouse   259 VEADHHFLVHWLKKLSQKKFKQLVERLLQFVSLRLFP------AKPEEFPPLTKCTWWIPSAAKV 317

  Fly   634 VPPQATPASNATPTTLTTTTNPPHRIVP--DLPQGLLEGADLLPKY------------------- 677
            :         |...|.....:||  :||  |.....|:..||:.:|
Mouse   318 L---------ALLNTANNLVHPP--LVPYTDFYNSTLDHIDLMEEYHTWQSFGNSHSRFSFCQYP 371

  Fly   678 ------------------------RRDLVGKL-RALRTELQTMQPQSGHCRLEVSRNEIFEESYR 717
                                    |:.||.|: |..|.::..:     ...::|.|..:..:|..
Mouse   372 FVISIAAKKIIIQRDSEQQMISIARQSLVDKVSRRQRPDMNML-----FLNMKVRRTHLVSDSLD 431

  Fly   718 LIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDS 782
            .:.:.|| |::|:|.|.|.||.|||.||:.:||..||.|::.:|.||:|.|.:|.|    .:..|
Mouse   432 ELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSH----CHWFS 491

  Fly   783 GVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP--------------ITLGDIEG 833
            ....|:.|.|..||..:|:||::...||..|....||:||:.|              :|:.|:..
Mouse   492 SFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDLCQ 556

  Fly   834 VDPDLHRSLTWML--ESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVN 896
            |.|:|...|..:|  |.|:.....|||.|....||.:..:.|||||..||||.:|:||||:||.:
Mouse   557 VMPELAHGLKELLSYEGNVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLYTD 621

  Fly   897 YRFMRGIEQQFLALQKGFCELIPSH---LLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNE 958
            :...:.|.:||.|...||..:..|:   ||||   .|:|:::.|...:|::..:.:|:.......
Mouse   622 FLLNKSIYKQFAAFYCGFHSVCASNALMLLRP---EEVEILVCGSPELDMHALQRSTQYDGYAKT 683

  Fly   959 TTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNL 1023
            ...:.:||.||..:..|::.:||.|.|||.|||:.|...|.          |.|... :..|..|
Mouse   684 DLTIRYFWDVVLGFPLELQKKLLHFTTGSDRVPVGGMADLN----------FKISKN-ETSTNWL 737

  Fly  1024 PKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            |.||||||::.||||::.:.|..||...:..:.||.:|
Mouse   738 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/32 (28%)
		WW	562..594	CDD:197736	10/118 (8%)
		HECTc	702..1058	CDD:238033	127/374 (34%)
		HECTc	726..1058	CDD:214523	122/350 (35%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		11/51 (22%)
		HECTc	416..773	CDD:238033	128/375 (34%)
		HECTc	439..772	CDD:214523	122/350 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810