Protein Alignment Smurf and Yap1

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_006509915.1
• Gene: Yap1 / 22601
• MGIID: 103262
• Length: 494
• Species: Mus musculus
• Alignment Length: 596
• Identity: 134/596 - (22%)
• Similarity: 197/596 - (33%)
• Gaps: 195/596 - (32%)

  Fly   335 PKHQTNGHAPPE--------STPTSPTGQQ-NYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQED 390
            |:....|.|||.        :.|..|.|.| .:|.|:::                      |..:
Mouse     9 PQPAPQGPAPPSVSPAGTPAAPPAPPAGHQVVHVRGDSE----------------------TDLE 51

  Fly   391 AA--TTTSPSTTTSP---PRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTA 450
            |.  ...:|.|...|   |...:..|.....||   .|.:    ||..| ||.||:.|      |
Mouse    52 ALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPP---EPKS----HSRQA-STDAGTAG------A 102

  Fly   451 ATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLD- 514
            .||               ...|..||..:...|....|....||.....||..||....:...:
Mouse   103 LTP---------------QHVRAHSSPASLQLGAVSPGTLTASGVVSGPAAAPAAQHLRQSSFEI 152

  Fly   515 -----LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPR--------IPRDFD---TQHLTLDAIGPL 563
                 ||.|:||..|..||.||.:.....:||.|||        :|....   .|.|...|.|||
Mouse   153 PDDVPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPAPASPAVPQTLMNSASGPL 217

  Fly   564 PSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATP 628
            |.||||..|..|.||:::|.|:||.:.||||.
Mouse   218 PDGWEQAMTQDGEVYYINHKNKTTSWLDPRLD--------------------------------- 249

  Fly   629 SAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQ 693
                   |:...|.|...|.......|| .:.|..|||.:.|            |.....:.::|
Mouse   250 -------PRFGKAMNQRITQSAPVKQPP-PLAPQSPQGGVLG------------GGSSNQQQQIQ 294

  Fly   694 TMQPQSGHCRLEVSRNEIFE----ESYRLIMKMRA-----KDMRKRLMVKFKGEEG-----LDYG 744
            ..|.|....||.:.:.|:|.    ::.|.|....|     :::..|..:....::|     :...
Mouse   295 LQQLQMEKERLRLKQQELFRQVRPQAIRNINPSTANAPKCQELALRSQLPTLEQDGGTPNAVSSP 359

  Fly   745 GVAREWLHLLSREMLNP--QYGLFQYSRDD---------HYTLQINPDSGVN------------- 785
            |:::| |..::....:|  ..|.: :|||:         .|::...||..:|
Mouse   360 GMSQE-LRTMTTNSSDPFLNSGTY-HSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTGDTISQ 422

  Fly   786 ----------PDHLSYFHFVGRTLGIAVFHGHC--LDGGFTTPFYKQLLNKPITLGDIEGV---- 834
                      ||:|.  ...|..:.:....|..  ::|....|..::.|:..|.  |:|.|
Mouse   423 STLPSQQSRFPDYLE--ALPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSEIL--DVESVLAAT 483

  Fly   835 DPDLHRSLTWM 845
            ..|....|||:
Mouse   484 KLDKESFLTWL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	15/45 (33%)
		WW	562..594	CDD:197736	17/31 (55%)
		HECTc	702..1058	CDD:238033	37/198 (19%)
		HECTc	726..1058	CDD:214523	30/165 (18%)
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	27/108 (25%)
		WW	159..188	CDD:238122	12/28 (43%)
		WW	217..246	CDD:366073	14/28 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810