DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Wwc1

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_740749.1 Gene:Wwc1 / 211652 MGIID:2388637 Length:1104 Species:Mus musculus


Alignment Length:571 Identity:117/571 - (20%)
Similarity:180/571 - (31%) Gaps:189/571 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   510 RPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTL-DAIG-PLPSGWEQRKT 572
            ||.|.||.|:|......|:||:.......::|.|   |||..|:.||. |.|. .||.|||:...
Mouse     3 RPELPLPEGWEEARDFDGKVYYIDHRNRTTSWID---PRDRYTKPLTFADCISDELPLGWEEAYD 64

  Fly   573 ASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQ 637
            .....||:|||.:|||..|||:                                           
Mouse    65 PQVGDYFIDHNTKTTQIEDPRV------------------------------------------- 86

  Fly   638 ATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHC 702
                                       |...|...:|..|   ||....||..:.:..|      
Mouse    87 ---------------------------QWRREQEHMLKDY---LVVAQEALSAQKEIYQ------ 115

  Fly   703 RLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYG--------GVAREWLHLLSREML 759
             ::..|.|:.::.|:.:..:....:..::.:.........|.        ..|:..::.|.|||:
Mouse   116 -VKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMV 179

  Fly   760 NPQYGLFQYSRDDHYTL-----QINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYK 819
            :.|:.| |:......||     :::...|                      |:.||.........
Mouse   180 HLQHEL-QFKERGFQTLKKIDERMSDAQG----------------------GYKLDEAQAVLRET 221

  Fly   820 QLLNKPITLGDIEGVDPDLHRSLTWMLESNI-------SGIIESTFSVENNSFGA----LVVHEL 873
            :.:.|.||.|:.|  ..||.:||. ||:...       |.:..|:.|:|::||..    |.|...
Mouse   222 KAIKKAITCGEKE--KQDLIKSLA-MLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQ 283

  Fly   874 KPGGASIPVTEENK-REYVKLYVNY-RFMRGIEQQFLALQKGFCELIPSHLLRPFDE----RELE 932
            .....|...:..|: .|.|:|.:.| ...|.|....:.|.|...|..|..|....|.    .|.|
Mouse   284 TDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKE 348

  Fly   933 LVIGGISSIDVNDW--------------------------------------RNNTRLKHCTNET 959
            .::..:..|....|                                      :.|..::.....|
Mouse   349 ELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEAT 413

  Fly   960 TQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFR------ALQGSTGA 1004
            .||......::|.||.|::    ..:|||...|...|      :|..||.|
Mouse   414 RQVATLHSQLKSLSSSMQS----LSSGSSPGSLTSSRGSLAASSLDSSTSA 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809
WW 514..546 CDD:197736 9/31 (29%)
WW 562..594 CDD:197736 15/31 (48%)
HECTc 702..1058 CDD:238033 72/377 (19%)
HECTc 726..1058 CDD:214523 69/353 (20%)
Wwc1NP_740749.1 WW 9..39 CDD:238122 9/32 (28%)
WW 55..84 CDD:278809 13/28 (46%)
ALDH-SF 378..>420 CDD:299846 4/41 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..449 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..547
C2_Kibra 661..784 CDD:176062
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..949
Interaction with histone H3. /evidence=ECO:0000250 836..1104
Interaction with PRKCZ. /evidence=ECO:0000250 945..988
ADDV motif 1102..1104
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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