DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Nedd4

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001344927.1	Gene:	Nedd4 / 17999	MGIID:	97297	Length:	1207	Species:	Mus musculus

Alignment Length:	1041	Identity:	311/1041 - (29%)
Similarity:	429/1041 - (41%)	Gaps:	338/1041 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 FLGIGDAITITVWNQRKI--------HKGSGFLGCVRIPAFNI--------------------QS 105
            |....|....:.|.||.:        .....|||.|.:|.:.:                    :|
Mouse   450 FASGNDGKVDSFWRQRDLTNELSDVCKTRDDFLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRS 514

  Fly   106 LKG--AGFQRLDLGKL----SPDD-----DELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGP 159
            .|.  .|:.||.:..|    |.|:     :||..|.:::     |.|.:...|           |
Mouse   515 HKSRVKGYLRLKMTYLPKNGSEDENADQAEELEPGWVVL-----DQPDAATHL-----------P 563

  Fly   160 SEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSG 224
            ...:.|  .||.|||||:...||.|||||.::.|||.||            ||..  :..:.::.
Mouse   564 HPPEPS--PLPPGWEERQDVLGRTYYVNHESRRTQWKRP------------SPDD--DLTDEDND 612

  Fly   225 DRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKK 289
            |.|..|  .|:.|....:     |.|:....:.|...:.||:..  .|||
Mouse   613 DMQLQA--QRAFTTRRQI-----SEDVDGPDNRESPENWEIVRE--DENT--------------- 653

  Fly   290 TSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTG 354
                   ...|:.::..|:......|......:.||....|             |..|.|.
Mouse   654 -------EYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGN-------------PATSQPV---- 694

  Fly   355 QQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPA 419
                         ||.|.|.:....|:..                      ..:.|..|.:.|
Mouse   695 -------------TSSNHSSRGGSLQTCI----------------------FEEQPTLPVLLP-- 722

  Fly   420 SVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGT 484
                                                                            |
Mouse   723 ----------------------------------------------------------------T 723

  Fly   485 SGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRI--- 546
            |.|                           ||||:|.:...:|:.|:....:..:||..|.:
Mouse   724 SSG---------------------------LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDD 761

  Fly   547 PRDFDTQHL----TLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTV 607
            ||.....||    ..:.:||||.|||:|....|||:|::||.:.||:.||||.
Mouse   762 PRSKIPAHLRGKTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQ------------ 814

  Fly   608 PPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGAD 672
                  |.....|            |||
Mouse   815 ------NVAITGP------------AVP------------------------------------- 824

  Fly   673 LLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRK-RLMVKFK 736
                |.||...|....|.:|:..........:::.|..|.|:|||.||.::..|:.| ||.::|.
Mouse   825 ----YSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFD 885

  Fly   737 GEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGV-NPDHLSYFHFVGRTLG 800
            ||:|||||||||||..|:|:||.||.||||:||..|:|||||||:||: |.||||||.|:||..|
Mouse   886 GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAG 950

  Fly   801 IAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSF 865
            :||:||..|||.|..||||.:|.|.|||.|:|.||.:.:.||.|:||::.:. ::..|.::...|
Mouse   951 MAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTE-LDLRFIIDEELF 1014

  Fly   866 GALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERE 930
            |....||||.||:.|.||.:||:||:.|.:.:||:..|::|..|.::||.||||..|::.|||.|
Mouse  1015 GQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENE 1079

  Fly   931 LELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQG 994
            |||::.|:..:||||||.:|:.|:..:...||: |||:.|....||.|.||||||||:||||:.|
Mouse  1080 LELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNG 1144

  Fly   995 FRALQGSTGAVGPRLFTIHL--TADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCG 1057
            |..|.||.   ||:.||:..  |.|    .||:|||||||:||||||::..|.|||..|:|.|.|
Mouse  1145 FAELYGSN---GPQSFTVEQWGTPD----KLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQG 1202

  Fly  1058 F 1058
            |
Mouse  1203 F 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	21/104 (20%)
		WW	169..198	CDD:278809	17/28 (61%)
		WW	514..546	CDD:197736	10/31 (32%)
		WW	562..594	CDD:197736	17/31 (55%)
		HECTc	702..1058	CDD:238033	184/360 (51%)
		HECTc	726..1058	CDD:214523	176/336 (52%)
Nedd4	NP_001344927.1	C2	<477..530	CDD:326325	10/52 (19%)
		WW	574..602	CDD:238122	17/39 (44%)
		WW	727..756	CDD:306827	9/28 (32%)
		WW	781..813	CDD:197736	17/31 (55%)
		HECTc	874..1203	CDD:214523	176/336 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740