Protein Alignment Smurf and hecw-1

DIOPT Version :10

• Sequence 1: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001317872.1
• Gene: hecw-1 / 175438
• WormBaseID: WBGene00009738
• Length: 1247
• Species: Caenorhabditis elegans
• Alignment Length: 1167
• Identity: 278/1167 - (23%)
• Similarity: 450/1167 - (38%)
• Gaps: 289/1167 - (24%)

  Fly    15 VRITILCARNLARKDLFRLPDPFAK------------VQVDGTGQVYSTEISKSSLDPKWNAHYD 67
            |:..:|...||..:||    :.|.|            ::|.|.......|:.| .||.:.:|:..
 Worm   250 VQTAMLIENNLTEQDL----NAFIKQWLRSDSDKLWWLEVKGKMMFNREEVLK-DLDVQDDAYRS 309

  Fly    68 LFLGIGDAITITVWN-QRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQI 131
            |         .|.|. .|:........||.|         |..|..|..|.:|.|....::.|.|
 Worm   310 L---------NTRWYVARRSRANPSGNGCAR---------KKMGSLRPKLTELWPFKVYIIFGSI 356

  Fly   132 IISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWD 196
            :|..    ||::.|.:..:                         ||.|             .:.|
 Worm   357 LIVF----GPAALNRMITL-------------------------RRMD-------------VETD 379

  Fly   197 RP--RQPGVVGSSHATSPQQRHNTHNGNSG---------DRQAPAGPTRSTTCTNLMNNGHRSRD 250
            ||  .:.|:..|..|..|       .||..         |:     |........|.:|...|
 Worm   380 RPSGSETGIFVSKSAVYP-------FGNKNEVVKVWWNIDK-----PENCLDWIGLFDNNDSS-- 430

  Fly   251 LSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKK----TSSSNSSSAGGRTLEQRPTNEP 311
            ..:.....|:|.:.::.::..:|....:.|......|..    ..|.|.......:|......:|
 Worm   431 FYLDQKSLRQHISPVVFTLTSKNLLNASEVYFGLIDGMTGRLLAKSENVEICKSASLVVHEVKKP 495

  Fly   312 ATPTSSTTSASVRLHSNDNHVKTPKHQT----NGH----------------APPESTP------- 349
                   .:.:|.|::|...::.||.::    ||.                :..|::.
 Worm   496 -------ENINVYLNTNHGRIEIPKKRSFSRKNGSFRSSFEFDFDVEDLHISLVENSEKLNFDHF 553

  Fly   350 -TSPTGQQNYVNGNAQNGS------------TSGNGSGQAAQPQSAS-----NGW-TQEDAAT-- 393
             .|...|.||:...:.:.|            ||...:....:..|:|     :.| |..||..
 Worm   554 IASNQLQNNYIQSKSFSHSHVVEIVFSIEPKTSKKSAPDIMEIASSSQTPPESHWKTYLDAKKRK 618

  Fly   394 -----TTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSP-NANSTPAGSGGGSRSYTAAT 452
                 .|..:..|.|...:.:    :|.|...|....:....|| |:..||      .|:.|..:
 Worm   619 FYVNHVTKETRWTKPDTLNNN----HIEPETPVHKRLSDRSASPRNSFITP------RRTITVRS 673

  Fly   453 PG----------QRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIA--AA 505
            .|          ||.:.:::..:.:::.                        |.|...::.  |.
 Worm   674 AGCPKSDLIQFFQRDEFKTALYENQDAM------------------------QIYNECSVVRHAI 714

  Fly   506 NQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQ-------HLTLDAIGPL 563
            ::..:   ||.|                             |..|:.|       :|..|...||
 Worm   715 HRIQK---DLDP-----------------------------PSKFENQPLFVRFVNLFADITQPL 747

  Fly   564 PSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPP--TSAANAG---------- 616
            ||||| ..|.:.|..|::|.|:.|.|.|||:.....:..|||...|  :|.|:.|
 Worm   748 PSGWE-CITMNNRTVFLNHANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKGKIDHALISKC 811

  Fly   617 TPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDL 681
            ......|....|..|..:..:...........:.:..|       ||...|  ...:|......|
 Worm   812 EDLRKIAQDNFPQIAERISKKLMLIERFGGLAVASLAN-------DLDITL--ALSMLDSNTEKL 867

  Fly   682 VGKLRALRTELQTMQPQ---SGHCRL--EVSRNEIFEESYRLIMKMRAKDMRK-RLMVKFKGEEG 740
            .|:...::...:.|:.:   .|..||  :|||:.:.::::|:|:.:....::| ||.::|:||..
 Worm   868 AGEGDNIKMFYEDMKKEKLGKGPSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIRFEGELA 932

  Fly   741 LDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFH 805
            |||||::||:..|||||:.:|:.|.|:|..:| |.||:.|..........:....||.|.:||.|
 Worm   933 LDYGGLSREFFILLSRELFHPKNGYFEYEGND-YHLQLRPRGCETEKEKKWLILCGRVLALAVIH 996

  Fly   806 GHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVV 870
            ...:|..||..|||.|..:|:||.|.:..|.:.::|:.|:||:::.. :|.:|...:...|.|..
 Worm   997 RCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLENDVVD-LEMSFVYSSMVNGKLAE 1060

  Fly   871 HELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVI 935
            .||.|||.|..|||.||.|::.|....:.:||:|:....|...|.:::..:||...:..:|:.::
 Worm  1061 QELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLLNSLESSDLKRIL 1125

  Fly   936 GGISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQ 999
            .|...:|:||||.||..|...::...|: |||:|:|:.:::.|..||.||||||.||.:||.||:
 Worm  1126 SGSLELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALR 1190

  Fly  1000 GSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            |:...   ..|.|....|  ..:.|:|||||||:.||.|.|.|.|..||.||:.....:::|
 Worm  1191 GNEEI---SKFCIEKWGD--ATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQAIVNGMSYSIE 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	31/132 (23%)
		PRP40	155..>283	CDD:227435	21/138 (15%)
		WW	169..198	CDD:459800	4/28 (14%)
		WW	514..546	CDD:197736	3/31 (10%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	133/359 (37%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:429626	8/38 (21%)
		WW	603..634	CDD:197736	6/30 (20%)
		HECW1_helix	679..741	CDD:465766	12/117 (10%)
		WW	746..777	CDD:197736	16/31 (52%)
		HECTc	918..1244	CDD:214523	126/332 (38%)