DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Itch

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_001230641.1 Gene:Itch / 16396 MGIID:1202301 Length:864 Species:Mus musculus


Alignment Length:835 Identity:296/835 - (35%)
Similarity:406/835 - (48%) Gaps:198/835 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   310 EPATPTSSTTSASVRLHSNDNHVKT---PKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGN 371
            |....|:..||.|.....||:..:|   .:..|||...||            |..:.:|...:||
Mouse   145 EAEVVTNGETSCSESTTQNDDGCRTRDDTRVSTNGSEDPE------------VAASGENKRANGN 197

  Fly   372 GSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANS 436
            .|      .|.|||..:        ||   .|||.|: ||.|....||||    ||   ||:.||
Mouse   198 NS------PSLSNGGFK--------PS---RPPRPSR-PPPPTPRRPASV----NG---SPSTNS 237

  Fly   437 TPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSG----GGGGGGSGQRY 497
            ...||..||.                      ..|....:..|..|.|||    ....||||.| 
Mouse   238 DSDGSSTGSL----------------------PPTNTNVNTSTSEGATSGLIIPLTISGGSGPR- 279

  Fly   498 ASAAIAAANQAARP--------------FLD-------------LPPGYEMRTTQQGQVYFYHIP 535
               .:...:||..|              ::|             ||||:|.|....|::|:....
Mouse   280 ---PLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHF 341

  Fly   536 TGVSTWHDPRIP--RDFD------------------------------TQHLTLDAIGPLPSGWE 568
            |..:||..|.:.  |:::                              :|:...|.:||||.|||
Mouse   342 TRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQNKEFDPLGPLPPGWE 406

  Fly   569 QRKTASGRVYFVDHNNRTTQFTDPRLSGSILQ------MIRRGTVPPTSAANAGTP--------A 619
            :|..::||||||:||.|.||:.|||..|.:.:      ...|.||.       |.|        |
Mouse   407 KRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVD-------GIPYFVDHNRRA 464

  Fly   620 PPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGK 684
            .....|.|..:|....||..                                     |.||...|
Mouse   465 TTYIDPRTGKSALDNGPQIA-------------------------------------YVRDFKAK 492

  Fly   685 LRALRTELQTM-QPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAR 748
            ::..|...|.: .||  |.::.|:|..:||:|::.||....:|:|:||.|.|.||||||||||||
Mouse   493 VQYFRFWCQQLAMPQ--HIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAR 555

  Fly   749 EWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGF 813
            ||..|||.|:|||.|.||:|:..|:|.|||||.|.:|||||.||.|:||.:.:|:|||..:|.||
Mouse   556 EWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGF 620

  Fly   814 TTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGG 877
            :.||||::||||:.|.|:|.:||:.:.||.|:.|:||... :|..|||:....|.:..|:|||.|
Mouse   621 SLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNG 685

  Fly   878 ASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSID 942
            .:|.||||||.||:::...:|..||:|:|..|..:||.|::|...|:.||.:|||:::.|:..||
Mouse   686 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 750

  Fly   943 VNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGP 1007
            :|||:.:...:|.|..:.|::||||.|:...:|.|.||||||||:.|:|:.||..|.||.   ||
Mouse   751 LNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN---GP 812

  Fly  1008 RLFTIHLTADVPTQN-LPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            :.|.|.   .|..:| ||::||||||:|||||::|:.|.:||..|:|||.||..|
Mouse   813 QKFCIE---KVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809
WW 514..546 CDD:197736 13/44 (30%)
WW 562..594 CDD:197736 20/31 (65%)
HECTc 702..1058 CDD:238033 175/357 (49%)
HECTc 726..1058 CDD:214523 168/333 (50%)
ItchNP_001230641.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..294 57/205 (28%)
WW 289..318 CDD:278809 2/28 (7%)
WW 321..350 CDD:278809 11/28 (39%)
Required for interaction with FYN. /evidence=ECO:0000250 356..432 24/75 (32%)
WW 401..430 CDD:278809 17/28 (61%)
WW 440..471 CDD:197736 6/37 (16%)
HECTc 509..862 CDD:238033 176/358 (49%)
HECTc 533..861 CDD:214523 168/333 (50%)
MAP kinase docking site 535..544 5/8 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.740

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