Sequence 1: | NP_001261061.1 | Gene: | Smurf / 36999 | FlyBaseID: | FBgn0029006 | Length: | 1061 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001230641.1 | Gene: | Itch / 16396 | MGIID: | 1202301 | Length: | 864 | Species: | Mus musculus |
Alignment Length: | 835 | Identity: | 296/835 - (35%) |
---|---|---|---|
Similarity: | 406/835 - (48%) | Gaps: | 198/835 - (23%) |
- Green bases have known domain annotations that are detailed below.
Fly 310 EPATPTSSTTSASVRLHSNDNHVKT---PKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGN 371
Fly 372 GSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANS 436
Fly 437 TPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSG----GGGGGGSGQRY 497
Fly 498 ASAAIAAANQAARP--------------FLD-------------LPPGYEMRTTQQGQVYFYHIP 535
Fly 536 TGVSTWHDPRIP--RDFD------------------------------TQHLTLDAIGPLPSGWE 568
Fly 569 QRKTASGRVYFVDHNNRTTQFTDPRLSGSILQ------MIRRGTVPPTSAANAGTP--------A 619
Fly 620 PPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGK 684
Fly 685 LRALRTELQTM-QPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAR 748
Fly 749 EWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGF 813
Fly 814 TTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGG 877
Fly 878 ASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSID 942
Fly 943 VNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGP 1007
Fly 1008 RLFTIHLTADVPTQN-LPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Smurf | NP_001261061.1 | C2_Smurf-like | 14..135 | CDD:176028 | |
WW | 169..198 | CDD:278809 | |||
WW | 514..546 | CDD:197736 | 13/44 (30%) | ||
WW | 562..594 | CDD:197736 | 20/31 (65%) | ||
HECTc | 702..1058 | CDD:238033 | 175/357 (49%) | ||
HECTc | 726..1058 | CDD:214523 | 168/333 (50%) | ||
Itch | NP_001230641.1 | C2_E3_ubiquitin_ligase | 17..140 | CDD:175988 | |
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 151..294 | 57/205 (28%) | |||
WW | 289..318 | CDD:278809 | 2/28 (7%) | ||
WW | 321..350 | CDD:278809 | 11/28 (39%) | ||
Required for interaction with FYN. /evidence=ECO:0000250 | 356..432 | 24/75 (32%) | |||
WW | 401..430 | CDD:278809 | 17/28 (61%) | ||
WW | 440..471 | CDD:197736 | 6/37 (16%) | ||
HECTc | 509..862 | CDD:238033 | 176/358 (49%) | ||
HECTc | 533..861 | CDD:214523 | 168/333 (50%) | ||
MAP kinase docking site | 535..544 | 5/8 (63%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5021 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 1 | 1.000 | - | - | FOG0000080 | |
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100256 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2273 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
5 | 4.740 |