DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	1210	Identity:	235/1210 - (19%)
Similarity:	360/1210 - (29%)	Gaps:	437/1210 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVG 205
            |.:|.|:    .||.:        ....||.||||..|:.|..|:::|..::|.:..|    |.|
Human    40 PRTGEPV----NSGHM--------IRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHP----VTG 88

  Fly   206 SSHATSP-------QQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHST 263
            .   .||       |:..|.|.......|.|:.....|:.....:.........:..|..:.|
Human    89 Q---FSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVH-- 148

  Fly   264 EILSSVGKEN----TSPTTPVSATTTPGKKTSSS------------------------------- 293
                |.||.:    .:|..||.......|:.||.
Human   149 ----SFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSI 209

  Fly   294 ----------------------------------NSSSAGGRTLEQ------------------- 305
                                              |||:||.:. ||
Human   210 PLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQA-EQSGMRTYYFSADTQEDMNAW 273

  Fly   306 -RPTNEPATPTSSTT------SASVRLHSNDNHVKTPKHQTNGHAPPESTPTSP-TGQQNYVNGN 362
             |..|:.|...|.::      ....:.....||.:: .|:. |...|..|...| .|..:.||..
Human   274 VRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTES-CHEC-GRVGPGHTRDCPHRGHDDIVNFE 336

  Fly   363 AQNGSTSGNGS-----------GQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPP---TP 413
            .|........|           .:|..|.|.:    :|||.....|    :.||..|:.|   ..
Human   337 RQEQEGEQYRSQRDPLEGKRDRSKARSPYSPA----EEDALFMDLP----TGPRGQQAQPQRAEK 393

  Fly   414 NISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAAT-PGQRSQRRSSRQQGEE-SSTRRRSS 476
            |...|||..|....            |:||..|::...| |.:.|||:|:..|.|. :..::..|
Human   394 NGMLPASYGPGEQN------------GTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDS 446

  Fly   477 RGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEM--RTTQQGQVYFYHIPTGVS 539
            |......|....|.|.|                   |..|..|:.  ::|:.        |:|.|
Human   447 RSLPLDQTLPRQGPGQS-------------------LSFPENYQTLPKSTRH--------PSGGS 484

  Fly   540 TWHDPRIPRDFD-----TQHLTLDAIGPLPSGWEQRKTASGRVYFV---------DHNNRTT--- 587
            :.....:|.|:.     ..||.:       |..|:|....|.|:.:         .|.:.|.
Human   485 SPPPRNLPSDYKYAQDRASHLKM-------SSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIC 542

  Fly   588 ----QFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSA----TPATPSAAAAVPPQATPAS-- 642
                :|||...|.|:|::.|..:||| |.::...|.||..    .|.||:....|.|.....|
Human   543 LGSPEFTDQGRSRSMLEVPRSISVPP-SPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVD 606

  Fly   643 --------NATPTTLTTTTNPPHRIVPDL-------------PQGLLEGADLLPKYRRDLVGKLR 686
                    .|....:..:::...|.:|.:             .:.|.|.:.||.:.||. ..||.
Human   607 ISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLRRH-QAKLA 670

  Fly   687 ALR---------------------TELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKR 730
            ::|                     |.|| ::....:..|::..||........::|..|:..|.|
Human   671 SVRNFAISQLLQHQLTFPTCQADDTYLQ-LKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPR 734

  Fly   731 LMVKFKGEEGLDYGGVAREWLHLLSREMLNP-----------------QYGLFQYSRDDHYTLQI 778
                 :...|.|          ||....|.|                 |..:.|...|....|:.
Human   735 -----RSMTGRD----------LLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKE 784

  Fly   779 NPDS---------------GVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPF------YKQLL 822
            |.|.               ...|.||....:..:.|...:.|........:|..      |.:|.
Human   785 NKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLE 849

  Fly   823 NKPITLGDIEGVDPDL---HRSL------------TWMLESNISGIIESTFSVENNSFGALVVHE 872
            |      |:|.:...|   ||..            .|.:|...:|:     |....:|..||...
Human   850 N------DVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGL-----SANKENFRILVESV 903

  Fly   873 LKPGGASIPV----------TEENK------------------REYVKL--YVNYR----FMRGI 903
            ..|...::|:          |.|:|                  |.:.:|  ||.||    .:|.:
Human   904 KNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKV 968

  Fly   904 EQQFLALQKGFCEL----------IPSHLLRPFDE--------RELELV----IGGISSIDVNDW 946
            .....:..|...::          :| .|..|.|:        ||..::    :.|:..  .:|.
Human   969 TSPLQSPTKAKPKVQEDEAPPRPPLP-ELYSPEDQPPAVPPLPREATIIRHTSVRGLKR--QSDE 1030

  Fly   947 RNNTR-LKHCTNETTQVLWFWQVVESYSSE---------MRARLLQFVTGSSRVPLQGFRALQGS 1001
            |...| |..|.|..::|     .:.||.||         |....|..|...||......|.|.||
Human  1031 RKRDRELGQCVNGDSRV-----ELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGS 1090

  Fly  1002 T------GAVGPRLFTIH--LTADVPTQNLPKAHTCFNRI 1033
            |      ..:.|.: |:.  |.|:......|:..:...|:
Human  1091 TSRLQQSSTIAPYV-TLRRGLNAESSKATFPRPKSALERL 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	11/28 (39%)
		WW	514..546	CDD:197736	6/33 (18%)
		WW	562..594	CDD:197736	10/47 (21%)
		HECTc	702..1058	CDD:238033	87/459 (19%)
		HECTc	726..1058	CDD:214523	82/435 (19%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827	235/1210 (19%)
		WW	56..85	CDD:306827	11/28 (39%)
		PH_PEPP1_2_3	159..281	CDD:270068	15/122 (12%)
		NESP55	<299..460	CDD:115071	43/182 (24%)
		DUF1640	779..905	CDD:311647	24/136 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900