DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Ube3b

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	438	Identity:	130/438 - (29%)
Similarity:	212/438 - (48%)	Gaps:	52/438 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 PHRIVPDLPQGLLEGADLLPKYRRDLVGKLRAL-RTELQTMQPQSGHCRLEVSRNEIFEESYRLI 719
            || :||...:.||        :|..::.:...| ..|..:..|...|  :.:.|:.:.|:.|..:
Mouse   647 PH-VVPHKNRVLL--------FRNMVIKEKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQL 700

  Fly   720 MKMRAKDMRKRLMVKFKG-----EEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQIN 779
            .::....|:..:.|||..     |.|:|..||.:|:|..:.:.:.:|...||:.:..|. .|..:
Mouse   701 RQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYPS 764

  Fly   780 PDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP-----ITLGDIEGVDPDLH 839
            |.|.::.::|..|.|||:.||.||:.|..:|..|.:.|..|:|...     .::.::..:|.:.:
Mouse   765 PTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFY 829

  Fly   840 RSLTWM--LESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRG 902
            ::||.:  .:.:|:. :..|.|.:.:..|.||.|||.|||.:||||:|||..|:.|..::|....
Mouse   830 KNLTSIKRYDGDIAD-LGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQ 893

  Fly   903 IEQQFLALQKGFCELIPSHLLRPFDERELE-LVIGGISSIDVNDWRNNTRLK---HCTNETTQVL 963
            |:.|..||..||..:|....:|.|...||: |:.|..:.||:.|.:.:|...   |.::..  ::
Mouse   894 IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRV--II 956

  Fly   964 WFWQVVES-YSSEMRARLLQFVTGSSRVPLQGFRALQ----------------GST-GAVGPRLF 1010
            |.|.::.| ::.|.||..|:|||..||.||.||..|:                |.| |:|....|
Mouse   957 WLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1021

  Fly  1011 TIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ||....  |...||.:.||||.:.||.|....:|.:||..|:....||
Mouse  1022 TIRKRE--PGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	117/389 (30%)
		HECTc	726..1058	CDD:214523	114/365 (31%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	120/392 (31%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	113/363 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810