DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and WWP2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens

Alignment Length:	910	Identity:	310/910 - (34%)
Similarity:	431/910 - (47%)	Gaps:	218/910 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 TRSTTCTN-LMNNGHRSRDLSVTASDERRHSTEILSSVGKENT----SPT-----TPVSATTTPG 287
            |.|...:| |.|||.:..::.:|.:.:..:...::|  |.|.|    .||     .|..:..|.|
Human    98 TASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVS--GGELTIFLDGPTVDLGNVPNGSALTDG 160

  Fly   288 KKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSP 352
            .:..|.:||...     ..|.|....|:::......|.|.              |:...:..|..
Human   161 SQLPSRDSSGTA-----VAPENRHQPPSTNCFGGRSRTHR--------------HSGASARTTPA 206

  Fly   353 TGQQN--YVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPST-----TTSPPRHSQSP 410
            ||:|:  ..:.:.|....||: ||.|       ||...::..|.|.|..     .||||
Human   207 TGEQSPGARSRHRQPVKNSGH-SGLA-------NGTVNDEPTTATDPEEPSVVGVTSPP------ 257

  Fly   411 PTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRS 475
                 :.|.||||       :||..|.||          .|||.          :|||.||
Human   258 -----AAPLSVTP-------NPNTTSLPA----------PATPA----------EGEEPST---- 286

  Fly   476 SRGTRNGGTSGGGGGGGSGQRYASAAIAAAN-------QAARP-----FLD-----------LPP 517
                             ||.:...||..|.:       |...|     ::|           |||
Human   287 -----------------SGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP 334

  Fly   518 GYEMRTTQQGQVYFYHIPTGVSTWHDP--RIPRDFD------------TQHLTL----------- 557
            |:|.||..:|:.|:....|..:||..|  ...|:::            .||.:.
Human   335 GWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399

  Fly   558 --DAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPP------TSAA- 613
              |.:||||.|||:|:. :||||:|:||.||||:.|||..|    ||:...:||      ||..
Human   400 DHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQG----MIQEPALPPGWEMKYTSEGV 459

  Fly   614 ------NAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGAD 672
                  |                                 |.|||...|.   |....|..:|:.
Human   460 RYFVDHN---------------------------------TRTTTFKDPR---PGFESGTKQGSP 488

  Fly   673 LLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKG 737
              ..|.|....|....|. |........|.::.|||..:||:|::.||.|:..|:|:||.:..:|
Human   489 --GAYDRSFRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRG 550

  Fly   738 EEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIA 802
            ||||||||:||||..|||.|:|||.|.||:|:..::|.|||||.|.:|||||:||.|:||.:.:|
Human   551 EEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMA 615

  Fly   803 VFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFG 866
            ::||..:|.|||.||||::|||..||.|:|.:||:.:.|:.|:.|:|:... :|..|..:....|
Human   616 LYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILG 680

  Fly   867 ALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDEREL 931
            .:..||||.||.||.||||||.||:.|..::||.||:|:|..|...||.|:.|...||.|||:||
Human   681 KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKEL 745

  Fly   932 ELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFR 996
            ||::.|:..||::||:.:|..:|.|..:.|:.||||||:...:|.|.||||||||:.|:|:.||.
Human   746 ELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFA 810

  Fly   997 ALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            .|.||.   ||:.|.|........  ||::||||||:|||||::|:.|.:||..|:|||.||..|
Human   811 ELIGSN---GPQKFCIDKVGKETW--LPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870

Fly 1062 1061
Human 871 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	14/44 (32%)
		WW	562..594	CDD:197736	20/31 (65%)
		HECTc	702..1058	CDD:238033	175/356 (49%)
		HECTc	726..1058	CDD:214523	166/332 (50%)
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	12/45 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299		53/233 (23%)
		Atrophin-1	<164..343	CDD:331285	61/264 (23%)
		WW	302..331	CDD:306827	3/28 (11%)
		WW	332..361	CDD:306827	12/28 (43%)
		WW	407..435	CDD:306827	17/28 (61%)
		WW	447..477	CDD:238122	10/65 (15%)
		HECTc	516..868	CDD:238033	176/356 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750