Protein Alignment Smurf and WWP1

DIOPT Version :10

• Sequence 1: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Alignment Length: 1127
• Identity: 333/1127 - (29%)
• Similarity: 488/1127 - (43%)
• Gaps: 294/1127 - (26%)

  Fly    10 NGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGD 74
            :|..::::|:..|:...:|:.|... .:.:|.||  |::..|..|.||.:|||:....:.:....
Human    15 SGRLQLQVTVSSAKLKRKKNWFGTA-IYTEVVVD--GEITKTAKSSSSSNPKWDEQLTVNVTPQT 76

  Fly    75 AITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKD 139
            .:...||:.|.: |....||...|      .||.|  ..:...||     |.|:.|:.:||.:|:
Human    77 TLEFQVWSHRTL-KADALLGKATI------DLKQA--LLIHNRKL-----ERVKEQLKLSLENKN 127

  Fly   140 GPSSGNPLAIV----------------GPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNH 188
            |.:....|.:|                .|:.:::      .:.|:|.|..|.......|:
Human   128 GIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQ------ENGDALHENGEPSARTTARL----- 181

  Fly   189 ATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHR--SRDL 251
            |.:.|                            |..|...|.......:|.:.:.||..  |...
Human   182 AVEGT----------------------------NGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPS 218

  Fly   252 SVTASDERRHSTEILSSVGKENT--------SPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPT 308
            .|.|..:...:.:.|:|...::|        :||...|.|.||.....::.|.:....|:|..|.
Human   219 QVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPV 283

  Fly   309 N---------------------------EPATPTSSTTSASVRLHSND-NHVKTPKHQTNGHAPP 345
            .                           ||.|..|.::||.....|.. :....|..|.:|:|..
Human   284 QEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANT 348

  Fly   346 ESTPT------SPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGW------------TQEDAA 392
            |:.|:      .|.|:..||:.|.:..:..        :||....||            ...:..
Human   349 ETLPSGWEQRKDPHGRTYYVDHNTRTTTWE--------RPQPLPPGWERRVDDRRRVYYVDHNTR 405

  Fly   393 TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRS 457
            |||....|....|:.:.                                          ...||:
Human   406 TTTWQRPTMESVRNFEQ------------------------------------------WQSQRN 428

  Fly   458 QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQR--YASAAIAAANQAARPFLDLPPGYE 520
            |.:.:.||                           ..||  |:::.:||.|.   |:..||||:|
Human   429 QLQGAMQQ---------------------------FNQRYLYSASMLAAEND---PYGPLPPGWE 463

  Fly   521 MRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNR 585
            .|.....:|||.:..|..:.|.|||      ||.|..:.  |||.|||.|.|..|..||||||.|
Human   464 KRVDSTDRVYFVNHNTKTTQWEDPR------TQGLQNEE--PLPEGWEIRYTREGVRYFVDHNTR 520

  Fly   586 TTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLT 650
            ||.|.|||...|                        |.|...|..|
Human   521 TTTFKDPRNGKS------------------------SVTKGGPQIA------------------- 542

  Fly   651 TTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEES 715
                                      |.|....||...|...|:....| |.::.|||..:||:|
Human   543 --------------------------YERGFRWKLAHFRYLCQSNALPS-HVKINVSRQTLFEDS 580

  Fly   716 YRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINP 780
            ::.||.::..|:|:||.|.|:|||||||||:||||..|||.|:|||.|.||:|:..::|.|||||
Human   581 FQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINP 645

  Fly   781 DSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWM 845
            .|.:||||||||.|:||.:.:|:|||..:|.||:.||||::|:|.:|:.|:|.:|.:.:.||.|:
Human   646 ASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWI 710

  Fly   846 LESNISGI-IESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLA 909
            .::||... :|..|||:....|.:..|:||.||::|.||||||.||:.|...:||.||:::|..|
Human   711 RDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKA 775

  Fly   910 LQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSS 974
            ...||.|::|...|:.|||:|||:::.|:..:|:.||:.||..:|.|..:.|::||||.|:...:
Human   776 FLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN 840

  Fly   975 EMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYE 1039
            |:|.||||||||:.|:||.||..|.||.   ||:.|.|....  ....||::||||||:|||||:
Human   841 EVRMRLLQFVTGTCRLPLGGFAELMGSN---GPQKFCIEKVG--KDTWLPRSHTCFNRLDLPPYK 900

  Fly  1040 TYQLLCDKLTQAVEETCGFAVE 1061
            :|:.|.:||..|:|||.||..|
Human   901 SYEQLKEKLLFAIEETEGFGQE 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	30/120 (25%)
		PRP40	155..>283	CDD:227435	22/137 (16%)
		WW	169..198	CDD:459800	6/28 (21%)
		WW	514..546	CDD:197736	13/31 (42%)
		WW	562..594	CDD:197736	21/31 (68%)
		HECTc	702..1058	CDD:238033	172/356 (48%)
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	36/139 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		38/185 (21%)
		SP1-4_N	<236..>344	CDD:425404	20/107 (19%)
		HUL4	<307..922	CDD:227354	265/777 (34%)
		Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000269|PubMed:34404733	349..531		67/269 (25%)