Protein Alignment Smurf and YAP1

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_005271435.1
• Gene: YAP1 / 10413
• HGNCID: 16262
• Length: 510
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 132/599 - (22%)
• Similarity: 197/599 - (32%)
• Gaps: 185/599 - (30%)

  Fly   335 PKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNG----SGQAAQPQSASNG----WTQEDA 391
            |:....|...|.|.|  |.||          |..||.|    :...|.||:...|    ..:.|:
Human     9 PQPAPQGQGQPPSQP--PQGQ----------GPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDS 61

  Fly   392 AT--------TTSPSTTTSP---PRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGS 445
            .|        ..:|.|...|   |...:..|.....||   .|.:    ||..| ||.||:.|
Human    62 ETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPP---EPKS----HSRQA-STDAGTAG-- 116

  Fly   446 RSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAAR 510
                |.||               ...|..||..:...|....|....:|.....||...|....:
Human   117 ----ALTP---------------QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQ 162

  Fly   511 PFLD------LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPR----------IPRDFDT-QHLTLD 558
            ...:      ||.|:||..|..||.||.:.....:||.|||          .|..... |::...
Human   163 SSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNS 227

  Fly   559 AIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSA 623
            |.||||.||||..|..|.:|:::|.|:||.:.||||.
Human   228 ASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLD---------------------------- 264

  Fly   624 TPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRAL 688
                        |:...|.|...:.......|| .:.|..|||.:.|            |.....
Human   265 ------------PRFGKAMNQRISQSAPVKQPP-PLAPQSPQGGVMG------------GSNSNQ 304

  Fly   689 RTELQTMQPQSGHCRLEVSRNEIFEESYRLIMK---------MRAKDMRKRLMVKFKGEEG---- 740
            :.:::..|.|....||.:.:.|:..:.....|:         .:.:::..|..:....::|
Human   305 QQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQN 369

  Fly   741 -LDYGGVAREWLHLLSREMLNP--QYGLFQYSRDD---------HYTLQINPDSGVN-------- 785
             :...|:::| |..::....:|  ..|.: :|||:         .|::...||..:|
Human   370 PVSSPGMSQE-LRTMTTNSSDPFLNSGTY-HSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTG 432

  Fly   786 ---------------PDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGV- 834
                           ||:|.........||.....|..::|....|..::.|:..| |.|:|.|
Human   433 DTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDI-LNDMESVL 496

  Fly   835 ---DPDLHRSLTWM 845
               ..|....|||:
Human   497 AATKLDKESFLTWL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	15/47 (32%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	36/196 (18%)
		HECTc	726..1058	CDD:214523	32/163 (20%)
YAP1	XP_005271435.1	WW	174..203	CDD:238122	12/28 (43%)
		WW	232..261	CDD:366073	13/28 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810