DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and HUWE1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_016884680.1	Gene:	HUWE1 / 10075	HGNCID:	30892	Length:	4501	Species:	Homo sapiens

Alignment Length:	959	Identity:	277/959 - (28%)
Similarity:	401/959 - (41%)	Gaps:	160/959 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHR-----SRDLSVTASDERRHSTEILSSVGK 271
            |:.:.:....|||...:......|||.|........     :....||::.....:|.|.:.|..
Human  3592 PENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVA 3656

  Fly   272 ENTSPTTPVSATTT----PGKKTSSSNSS-SAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNH 331
            .:|:.|||.:||||    |..|.|.|.:. |.||              :|||....|.....:|.
Human  3657 ASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGG--------------SSSTDFKMVSSGLTENQ 3707

  Fly   332 VKTPKHQTNGHAPPE----------------STPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQ 380
            ::........|:..|                .:.|..|..:..:||....|.|.....|......
Human  3708 LQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAEL 3772

  Fly   381 SASNGWTQEDA-ATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGG 444
            ...|...|..| ..|.||....     .:.|.|..:............||....:...|.|
Human  3773 REYNLEQQRRAQCETLSPDGLP-----EEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLG---- 3828

  Fly   445 SRSYTAATPGQRSQRRSSRQQGEESSTR-----------------RRSSRGTRNGGTSGGGGGGG 492
                     |:..|..|......::||:                 ||:::..:..|..|..|.|.
Human  3829 ---------GRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGS 3884

  Fly   493 SGQRYASAAIAAANQAARPFLDL-PPGYEMRTTQQ----------GQVYFYHIPTGVSTWHDPRI 546
            :..  ..||:......|...:.: ..|...|..||          ..|.....|..|    |...
Human  3885 ASS--IQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDV----DQPS 3943

  Fly   547 PRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFV----------------------DHNNRTTQF 589
            |...|||.:..|.   .|.|.::::.....:..:                      .|:......
Human  3944 PSAQDTQSIASDG---TPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLV 4005

  Fly   590 TDPRLSGSIL-QMIRRGTVPPTS-------AANAGTPAPPSATPATPSAAAAVPPQATPASNATP 646
            ..|.:....| ....|.:.||..       |.....|.|.|..|.||    |.|....|..:..|
Human  4006 LQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTP----ATPSSLDPFFSREP 4066

  Fly   647 TTLTTTTN-PP-----------HRIVPD--LPQGLLEGAD----LLPKYRR--DLVGKLRALRTE 691
            :::..::: ||           ||.|.:  |.|.....||    :|..|.|  |...|.:..|.|
Human  4067 SSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQE 4131

  Fly   692 LQTMQP--QSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLL 754
            |:.:..  :.....:.|.|:.:||:|||.:.:...::|:.||.:.|:||||.|.||:.|||..::
Human  4132 LERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMII 4196

  Fly   755 SREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYK 819
            ||||.||.|.||:.|..|..|..|||.|..||:|||||.||||.:..||:....|:..||..|||
Human  4197 SREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYK 4261

  Fly   820 QLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGGASIPVT 883
            .:|.|.:...|:|..|...::.|.::||:::|.: .:.|||.|...||...|.:|||.||:|.||
Human  4262 HILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVT 4326

  Fly   884 EENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRN 948
            ||||:|||.|....|....|.:|..|..:||.|:||..|:..|.|:||||:|.|:.:||::|.::
Human  4327 EENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKS 4391

  Fly   949 NTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIH 1013
            ||......:.:.|:.|||:.:.|:....||:.||||||:|:||||||.||:|..|.   :.|.||
Human  4392 NTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI---QKFQIH 4453

  Fly  1014 LTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETC--GFAV 1060
             ..|..|..||.||||||::|||.||:::.|...|..|::| |  ||.:
Human  4454 -RDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE-CSEGFGL 4500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	8/42 (19%)
		WW	562..594	CDD:197736	4/53 (8%)
		HECTc	702..1058	CDD:238033	158/358 (44%)
		HECTc	726..1058	CDD:214523	151/334 (45%)
HUWE1	XP_016884680.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810