DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and hecw2b

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:XP_003197660.3 Gene:hecw2b / 100331355 ZFINID:ZDB-GENE-101001-3 Length:1472 Species:Danio rerio


Alignment Length:1382 Identity:360/1382 - (26%)
Similarity:517/1382 - (37%) Gaps:467/1382 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RKDLFRLPDPFAKVQV-----------DGTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:           ...||...|.|..::.:|.|:.....|:.: .|.:.|.
Zfish   211 KKGMFFNPDPYLKMSIQPGKRNGFPTFSHHGQERRTSIISNTTNPVWHGEKYTFVALMTDVLEIE 275

  Fly    80 VWNQ----RKIHKGSGFLG------------------------CVRIP--------------AFN 102
            |.::    |.|.|  .|||                        |.|:|              .||
Zfish   276 VKDKFAKSRPIIK--RFLGQLIIPVQRLLERHTAGDQHVSYTLCRRLPTEHVSGQLHFRVEITFN 338

  Fly   103 -----IQSLKGAGFQRLDLGKLSPDDDE--------LVRGQIIISLLSKDGPSSGNPLAIVGPSG 154
                 :.||.||.....|.|  ||.|||        :|||.   |....:|...|:...   |..
Zfish   339 GHEDAMGSLLGASAMNGDPG--SPSDDEDVLQPVSRMVRGP---SPTGSEGSLHGDAFR---PDE 395

  Fly   155 DVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPG--VVGSSHATSPQQRHN 217
            .:..|.||....|..|:..|.......|...:|....:.  :.|:.||  .:|   |:||:.|.:
Zfish   396 CMMDPEEDRLLRDGAPDLAEGAPAHTHRQSSLNDYLDAI--EAPKPPGDRPLG---ASSPKLRSS 455

  Fly   218 ----------THNGNSGDRQAPAGPTRSTTCTNLM--NNGHRSRDL---SVTASDERRHSTEILS 267
                      .|..:..|.:..|  :|.|..||.|  ..||.|.:.   .|...:..|..:|..|
Zfish   456 FPTDTRLNAMLHIDSDEDEEGHA--SRDTALTNGMPRPEGHASSERGKGEVHVKNRERLESEAAS 518

  Fly   268 SVGKENTSPTTPVSATTTPGKKTSSSNSSSA----------GGRTLEQRPTNEPATPTSSTTSAS 322
            |.  .:|..|..||::.|    |.|.|...|          ||.|.......:||          
Zfish   519 SA--TDTEATASVSSSGT----TKSQNGGGAEGGQEGAAISGGLTQSISSFQQPA---------- 567

  Fly   323 VRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWT 387
            :|:...:           |.||..|:                  .|.|:....|....|||..:|
Zfish   568 LRIQDEE-----------GAAPQASS------------------RTEGSSEAPAVSEASASAIYT 603

  Fly   388 QEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAAT 452
            ..:....|:   |..|.|.:.|..|                                        
Zfish   604 VNEVGGATA---TNQPERMNSSEMT---------------------------------------- 625

  Fly   453 PGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAA------------- 504
                    :..::.||...||||.:.:.|...:.....|...:|.|..|.||             
Zfish   626 --------NQEEEDEEIWQRRRSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQV 682

  Fly   505 -ANQAARPF------------LD--LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIP------- 547
             .:|..|..            :|  |||.:|.|....|::::.......:||..|..|       
Zfish   683 NGHQPMRSLPSVRHDISRYQRVDEPLPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 747

  Fly   548 ------------RDFDTQHLTL---------------------------------DAIGP----- 562
                        |.:.:...|:                                 ..:||     
Zfish   748 RSNSIQQMEQLNRRYQSIRRTITNERTEEQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRS 812

  Fly   563 ----------------------------------------------------------------- 562
                                                                             
Zfish   813 RLTLLLQSPSAKFLTSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLVAF 877

  Fly   563 ----------LPSGWEQRKTASGRVYFVDHNNRTTQFTDPRL------SGSIL---QMIRR---- 604
                      ||.|||.:...:|:.:|||||.|.|.|.||||      ..|:|   |.:.|    
Zfish   878 LNMFANKQLDLPRGWEMKHDHTGKPFFVDHNCRATTFIDPRLPLQSARPSSLLAHRQHLSRQRSH 942

  Fly   605 --GTV--PPTSAANAGTPAPPSATPATPSAAAAVPPQA---------------------TP---- 640
              |.|  .|..|..|..|.|.:...|..:....:.|.|                     .|    
Zfish   943 SAGEVGDDPRHAGPAVLPRPSNTFTANRNQCQDLVPVAYNEKIVAFLRQPNIFDILQERQPELIR 1007

  Fly   641 ----------------------ASNATPTTLTTTTN-------PPHRIV---------------P 661
                                  :|:|....|.:...       |||.::               |
Zfish  1008 NHSLREKVQFIRNEGASGLARLSSDADLVILLSLFEEEVMSYVPPHALLHPSYCQSPRGSPVSSP 1072

  Fly   662 DLPQGLLEGADLLP-KYRRDLVGKLRALRTELQT----MQPQSGHCRLEVSRNEIFEESYRLIMK 721
            ....|........| .|:||...|||....:|:|    ..|  |..:|.:.|:.:.|:::..||.
Zfish  1073 QNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGP--GKVKLIIRRDHLLEDAFNQIMC 1135

  Fly   722 MRAKDM-RKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVN 785
            ...||: |.:|.|.|.|||||||.|.:||:..|:|||:.||.||||:||.:|.||:||:|.|...
Zfish  1136 YSRKDLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV 1200

  Fly   786 PDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNI 850
            .:|..:|.|.||.||:|:.|.:.||..||.||||.||..|..|.|:|.:|.:.|:||.||.:::|
Zfish  1201 DNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDNDI 1265

  Fly   851 SGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFC 915
            ..:::.||:|....||.:...|||||||:|||:|:||:||::..|.:|..||:.||..:|.:||.
Zfish  1266 EDMLDLTFTVNEEVFGQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVRGFY 1330

  Fly   916 ELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRAR 979
            |::.:.|:..||.|||||||.|.:.||:.||||||..:...::...|: |||..||.:::|.|.|
Zfish  1331 EVVDARLVSVFDARELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1395

  Fly   980 LLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLL 1044
            |||||||:|.:|.:||.:|:||.   |||.|.:.....:  .:||:|||||||:|||||.::.:|
Zfish  1396 LLQFVTGTSSIPYEGFASLRGSN---GPRRFCVEKWGKI--TSLPRAHTCFNRLDLPPYPSFSML 1455

  Fly  1045 CDKLTQAVEETCGFAVE 1061
            .:|:..|||||..|.:|
Zfish  1456 YEKMLTAVEETSTFGLE 1472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 41/174 (24%)
WW 169..198 CDD:278809 4/28 (14%)
WW 514..546 CDD:197736 10/33 (30%)
WW 562..594 CDD:197736 17/111 (15%)
HECTc 702..1058 CDD:238033 167/357 (47%)
HECTc 726..1058 CDD:214523 161/333 (48%)
hecw2bXP_003197660.3 HECW_N 58..177 CDD:318711
C2_NEDL1-like 198..334 CDD:176073 25/124 (20%)
LGT <491..633 CDD:320995 40/237 (17%)
WW 708..737 CDD:306827 8/28 (29%)
WW 887..919 CDD:197736 16/31 (52%)
HECTc 1117..1470 CDD:238033 167/357 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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