DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and hecw1

DIOPT Version :10

Sequence 1:NP_523779.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:XP_017950053.1 Gene:hecw1 / 100170498 XenbaseID:XB-GENE-5969056 Length:1600 Species:Xenopus tropicalis


Alignment Length:1407 Identity:366/1407 - (26%)
Similarity:543/1407 - (38%) Gaps:398/1407 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 RKDLFRLPDPFAKVQVD-----------GTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:.           ..||...::|..::::|.|......|:.: .|.:.|.
 Frog   220 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQEKRSKIVCNTVNPVWKRELFSFVSLPTDVLEIE 284

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD--LGK-------------------- 118
            |.::    |.|.|  .|||.:.:|...:......|.:.:.  ||:                    
 Frog   285 VKDKFAKSRPIIK--RFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSS 347

  Fly   119 LSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDV----RGPSEDDSSEDSLPEGWEERRTD 179
            :.|||:|     |.:|..:..|.:|.:||........:    |.....:.|...||   .|..:.
 Frog   348 IHPDDEE-----ISVSSDTVPGTASASPLHNTNEETPIESQRRASVATECSSQELP---NECISA 404

  Fly   180 NGRVYYVNHATKSTQWDRPRQPGVVGS--SHATSPQQRHNTHNGN-------------------- 222
            ||........::||. .......:.||  ::|:..:...|..:|.                    
 Frog   405 NGHDKNSASGSRSTS-QNSLHKNITGSAMANASGAELTENLDSGQAEMTLPVDFIDSVQEQAACV 468

  Fly   223 ---------------------------------------SGDRQ-APAGP------------TRS 235
                                                   |.|:: ||..|            .|:
 Frog   469 DSEAKLENIVVSVAAAAAAGQNENPEILDVDEENMLLEASKDQEKAPEEPEGGCPLPDGEPKLRN 533

  Fly   236 TT------CT----------------------------NLMNNGHRSRDLSVTASDERRHSTEIL 266
            |.      |:                            ||::: ..|..:|....:|.::|.::.
 Frog   534 TVKRKNRPCSLPVSELETVIASACGEPETPRTHYIRIHNLLHS-LPSAQMSGDGDEEEQNSVDLD 597

  Fly   267 SSVGKENTSPTTPVSATTTPGKKTSS-----SNSSSAGGRTLEQRPTNEPATP------------ 314
            .....:.||....||.|.|.....||     .|......|:.....:..|..|            
 Frog   598 EESTVKETSEKDIVSETETVAPDPSSEVVIDENDDVENSRSPLPLDSTSPHLPSCNHNCLDVELL 662

  Fly   315 -TSSTTSASVRLHSN-------------------------------DNHVKTPKH---------- 337
             |.|.:.:|.|:|.:                               |:|.:...|          
 Frog   663 RTESESDSSARVHGDHECDTCDTSCYSTSCYSTSCYSTSCYSPSCYDSHNRFSSHTRFSSVDSAR 727

  Fly   338 ------------QTNGHAPPESTP---TSPTGQQNYVNGNAQ-NGSTSGNG------SGQAAQPQ 380
                        :.:.::..||.|   .||..:::..:|:.| :..|||..      .|....|.
 Frog   728 MSESTVFSSQDDEEDENSAFESMPDSNQSPEPERDQADGSNQWSDDTSGQSVNSERTLGVLESPV 792

  Fly   381 SASNGWTQEDAA-TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHS-------PNANST 437
            :..:..|:.|.. ..|:||.|..|...:.....|.|..|  :.|:....:.|       .:.|.|
 Frog   793 AGPSNRTEGDCTLPNTTPSVTQLPSLRADHHHYPTIDEP--LPPNWEARIDSHGRVFYVDHVNRT 855

  Fly   438 PAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGT----RNGGTSGGGGGGGSGQRYA 498
            ..    ..|..|||||...| |..|.||.|:.:.|.::.:.|    |....|.|......|...:
 Frog   856 TT----WQRPTTAATPDGIS-RSGSIQQMEQLNRRYQNIQRTIATERTEEDSLGRNDRAPGVGDS 915

  Fly   499 SAAIAAANQAARPFLDLPPGYEMRTT---QQGQVYFYHIPTGVSTWHD----------------- 543
            ...::..|...|....|.|....:.|   |...|.|...|...:..|.                 
 Frog   916 ETDLSQPNTELRREGSLTPINSQKITLLLQSPAVKFITNPEFFTILHANYSAYRVFTNSTCLKHM 980

  Fly   544 ----PRIPRDFDTQHLTLDAIG----------PLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRL 594
                .|..|:|:......|.:.          .||.|||.:....|:.:|||||:|.|.|.|||:
 Frog   981 VLKIRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1045

  Fly   595 ---SGSI---------LQMIRRGTVPPTSAANAGTPAPPSATPATPSAAA--------AVP---- 635
               :|.:         ||.:|..:....|..:....|...|.|......|        |||    
 Frog  1046 PLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVTAVRNQHQHEAVPLAYN 1110

  Fly   636 ------------------PQATPASN----------ATPTT------------------------ 648
                              .|.:.|.|          .|..|                        
 Frog  1111 DKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTHGLEKLSCDADLVILLSLFEEDIM 1175

  Fly   649 ----LTTTTNPPHRIVP-----DLPQ---GLLEGADLLPK-YRRDLVGKLRALRTELQT----MQ 696
                |....:|.:...|     ..||   ||...:...|. ||||...|||....:|:.    ..
 Frog  1176 SYIPLQAAFHPGYSFSPRCSPGSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGYGQG 1240

  Fly   697 PQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGVAREWLHLLSREMLN 760
            |  |..:|.:.|:.:.|.::..:|....|:: |.:|.:.|.|||||||.|.:||:..|||:|:.|
 Frog  1241 P--GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFN 1303

  Fly   761 PQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
            |.||||:||.:|.||:||:|.|....:||.:|.|.||.||:|:.|.:.||..||.||||.||..|
 Frog  1304 PYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLP 1368

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREY 890
            ..|.|:|.:|.:.|:||.||.:::|:.|::.||:|....||.:...|||.|||:|.|:|:||:||
 Frog  1369 CDLSDLEYLDEEFHQSLQWMKDNDITDILDLTFTVNEEVFGQVTERELKSGGANIQVSEKNKKEY 1433

  Fly   891 VKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHC 955
            ::..|.:|..||:.||..||.:||.|::.|.|:..||.|||||||.|.:.||:|||||||..:..
 Frog  1434 IEKMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGG 1498

  Fly   956 TNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVP 1019
            .::...|: |||..||.:::|.|.||||||||:|.||.:||.||:||.|.   |.|.|.....: 
 Frog  1499 YHDGHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKI- 1559

  Fly  1020 TQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
             .:||:|||||||:|||||.:|.:|.:||..|||||..|.:|
 Frog  1560 -TSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTFGLE 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_523779.1 C2_Smurf-like 14..135 CDD:176028 30/145 (21%)
PRP40 155..>283 CDD:227435 32/239 (13%)
WW 169..198 CDD:459800 7/28 (25%)
WW 514..546 CDD:197736 8/55 (15%)
WW 562..594 CDD:197736 16/31 (52%)
HECTc 702..1058 CDD:238033 171/357 (48%)
hecw1XP_017950053.1 HECW_N 67..184 CDD:465177
C2_NEDL1-like 207..343 CDD:176073 25/124 (20%)
PRK08581 576..>791 CDD:236304 35/215 (16%)
Keratin_B2_2 680..710 CDD:464017 0/29 (0%)
WW 832..861 CDD:459800 4/32 (13%)
HECW1_helix 942..1008 CDD:465766 9/65 (14%)
WW 1014..1045 CDD:197736 16/30 (53%)
HECTc 1268..1597 CDD:214523 166/333 (50%)
Blue background indicates that the domain is not in the aligned region.

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