DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and hecw1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_017950053.1	Gene:	hecw1 / 100170498	XenbaseID:	XB-GENE-5969056	Length:	1600	Species:	Xenopus tropicalis

Alignment Length:	1407	Identity:	366/1407 - (26%)
Similarity:	543/1407 - (38%)	Gaps:	398/1407 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RKDLFRLPDPFAKVQVD-----------GTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:.           ..||...::|..::::|.|......|:.: .|.:.|.
Frog   220 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQEKRSKIVCNTVNPVWKRELFSFVSLPTDVLEIE 284

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLD--LGK-------------------- 118
            |.::    |.|.|  .|||.:.:|...:......|.:.:.  ||:
Frog   285 VKDKFAKSRPIIK--RFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSS 347

  Fly   119 LSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDV----RGPSEDDSSEDSLPEGWEERRTD 179
            :.|||:|     |.:|..:..|.:|.:||........:    |.....:.|...||   .|..:.
Frog   348 IHPDDEE-----ISVSSDTVPGTASASPLHNTNEETPIESQRRASVATECSSQELP---NECISA 404

  Fly   180 NGRVYYVNHATKSTQWDRPRQPGVVGS--SHATSPQQRHNTHNGN-------------------- 222
            ||........::||. .......:.||  ::|:..:...|..:|.
Frog   405 NGHDKNSASGSRSTS-QNSLHKNITGSAMANASGAELTENLDSGQAEMTLPVDFIDSVQEQAACV 468

  Fly   223 ---------------------------------------SGDRQ-APAGP------------TRS 235
                                                   |.|:: ||..|            .|:
Frog   469 DSEAKLENIVVSVAAAAAAGQNENPEILDVDEENMLLEASKDQEKAPEEPEGGCPLPDGEPKLRN 533

  Fly   236 TT------CT----------------------------NLMNNGHRSRDLSVTASDERRHSTEIL 266
            |.      |:                            ||::: ..|..:|....:|.::|.::.
Frog   534 TVKRKNRPCSLPVSELETVIASACGEPETPRTHYIRIHNLLHS-LPSAQMSGDGDEEEQNSVDLD 597

  Fly   267 SSVGKENTSPTTPVSATTTPGKKTSS-----SNSSSAGGRTLEQRPTNEPATP------------ 314
            .....:.||....||.|.|.....||     .|......|:.....:..|..|
Frog   598 EESTVKETSEKDIVSETETVAPDPSSEVVIDENDDVENSRSPLPLDSTSPHLPSCNHNCLDVELL 662

  Fly   315 -TSSTTSASVRLHSN-------------------------------DNHVKTPKH---------- 337
             |.|.:.:|.|:|.:                               |:|.:...|
Frog   663 RTESESDSSARVHGDHECDTCDTSCYSTSCYSTSCYSTSCYSPSCYDSHNRFSSHTRFSSVDSAR 727

  Fly   338 ------------QTNGHAPPESTP---TSPTGQQNYVNGNAQ-NGSTSGNG------SGQAAQPQ 380
                        :.:.::..||.|   .||..:::..:|:.| :..|||..      .|....|.
Frog   728 MSESTVFSSQDDEEDENSAFESMPDSNQSPEPERDQADGSNQWSDDTSGQSVNSERTLGVLESPV 792

  Fly   381 SASNGWTQEDAA-TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHS-------PNANST 437
            :..:..|:.|.. ..|:||.|..|...:.....|.|..|  :.|:....:.|       .:.|.|
Frog   793 AGPSNRTEGDCTLPNTTPSVTQLPSLRADHHHYPTIDEP--LPPNWEARIDSHGRVFYVDHVNRT 855

  Fly   438 PAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGT----RNGGTSGGGGGGGSGQRYA 498
            ..    ..|..|||||...| |..|.||.|:.:.|.::.:.|    |....|.|......|...:
Frog   856 TT----WQRPTTAATPDGIS-RSGSIQQMEQLNRRYQNIQRTIATERTEEDSLGRNDRAPGVGDS 915

  Fly   499 SAAIAAANQAARPFLDLPPGYEMRTT---QQGQVYFYHIPTGVSTWHD----------------- 543
            ...::..|...|....|.|....:.|   |...|.|...|...:..|.
Frog   916 ETDLSQPNTELRREGSLTPINSQKITLLLQSPAVKFITNPEFFTILHANYSAYRVFTNSTCLKHM 980

  Fly   544 ----PRIPRDFDTQHLTLDAIG----------PLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRL 594
                .|..|:|:......|.:.          .||.|||.:....|:.:|||||:|.|.|.|||:
Frog   981 VLKIRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1045

  Fly   595 ---SGSI---------LQMIRRGTVPPTSAANAGTPAPPSATPATPSAAA--------AVP---- 635
               :|.:         ||.:|..:....|..:....|...|.|......|        |||
Frog  1046 PLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVTAVRNQHQHEAVPLAYN 1110

  Fly   636 ------------------PQATPASN----------ATPTT------------------------ 648
                              .|.:.|.|          .|..|
Frog  1111 DKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTHGLEKLSCDADLVILLSLFEEDIM 1175

  Fly   649 ----LTTTTNPPHRIVP-----DLPQ---GLLEGADLLPK-YRRDLVGKLRALRTELQT----MQ 696
                |....:|.:...|     ..||   ||...:...|. ||||...|||....:|:.    ..
Frog  1176 SYIPLQAAFHPGYSFSPRCSPGSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGYGQG 1240

  Fly   697 PQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGVAREWLHLLSREMLN 760
            |  |..:|.:.|:.:.|.::..:|....|:: |.:|.:.|.|||||||.|.:||:..|||:|:.|
Frog  1241 P--GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFN 1303

  Fly   761 PQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
            |.||||:||.:|.||:||:|.|....:||.:|.|.||.||:|:.|.:.||..||.||||.||..|
Frog  1304 PYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLP 1368

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREY 890
            ..|.|:|.:|.:.|:||.||.:::|:.|::.||:|....||.:...|||.|||:|.|:|:||:||
Frog  1369 CDLSDLEYLDEEFHQSLQWMKDNDITDILDLTFTVNEEVFGQVTERELKSGGANIQVSEKNKKEY 1433

  Fly   891 VKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHC 955
            ::..|.:|..||:.||..||.:||.|::.|.|:..||.|||||||.|.:.||:|||||||..:..
Frog  1434 IEKMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGG 1498

  Fly   956 TNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVP 1019
            .::...|: |||..||.:::|.|.||||||||:|.||.:||.||:||.|.   |.|.|.....:
Frog  1499 YHDGHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKI- 1559

  Fly  1020 TQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
             .:||:|||||||:|||||.:|.:|.:||..|||||..|.:|
Frog  1560 -TSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTFGLE 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	30/145 (21%)
		WW	169..198	CDD:278809	7/28 (25%)
		WW	514..546	CDD:197736	8/55 (15%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	171/357 (48%)
		HECTc	726..1058	CDD:214523	166/333 (50%)
hecw1	XP_017950053.1	HECW_N	67..186	CDD:374632
		C2_NEDL1-like	207..343	CDD:176073	25/124 (20%)
		MSCRAMM_SdrC	<588..786	CDD:380146	32/197 (16%)
		WW	832..861	CDD:366073	4/32 (13%)
		HECW1_helix	942..1008	CDD:375862	9/65 (14%)
		WW	1014..1045	CDD:197736	16/30 (53%)
		HECTc	1268..1597	CDD:214523	166/333 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000