Protein Alignment Smurf and hecw2a

DIOPT Version :10

• Sequence 1: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_021334623.2
• Gene: hecw2a / 100150269
• ZFINID: ZDB-GENE-090311-22
• Length: 1475
• Species: Danio rerio
• Alignment Length: 1356
• Identity: 354/1356 - (26%)
• Similarity: 521/1356 - (38%)
• Gaps: 402/1356 - (29%)

  Fly    27 RKDLFRLPDPFAKVQV-----------DGTGQVYSTEISKSSLDPKWNAHYDLFLGI-GDAITIT 79
            :|.:|..|||:.|:.:           ...||...:.|:.::.:|.|:.....|:.: .|.:.|.
Zfish   201 KKGMFFNPDPYLKMSIHPGKRSCFPTFSHHGQERRSGITTNTTNPVWHGEKHTFVALMTDVLVIE 265

  Fly    80 VWNQ----RKIHKGSGFLGCVRIPAFNIQSLKGAGFQ---------------------RLDLGKL 119
            |.::    |.|.|  .|||.:.||...:......|.|                     ::|:..:
Zfish   266 VKDKFAKSRPIIK--RFLGQLNIPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMHFKVDVTSM 328

  Fly   120 SPDD--DELVRGQIIIS----------------LLSKDGPS---------SGNPLAIVGPSGDVR 157
            .|||  .|.:.|...::                .:|..|||         :|...:|..|..::.
Zfish   329 GPDDVSPETILGAAALNGAPGTPSDDEELPHPLPISSAGPSPTASLGSNRNGEGSSIPSPDTEIY 393

  Fly   158 GPSEDD---SSEDSLPEGWEERRTDNGRVYYVNHATKSTQWD---RPRQPG--VVGSSHATSPQQ 214
            |.:.||   ||.|.|...:.|                  |.|   .|:.||  .:|   |.||:.
Zfish   394 GGTLDDEAPSSPDLLQGSFSE------------------QLDAIEAPKGPGDRPLG---AASPKL 437

  Fly   215 RHN--THNGNSG----------DRQAPAGPTRSTTCTNLMNNGHRSRDLSVTA------------ 255
            |.:  ||...|.          ||.|....|.||     .|...||......|
Zfish   438 RSSFPTHTRLSAMLHIDSDEDEDRSAATEATLST-----FNGIPRSYQTPPKAAARGAVFDGGVE 497

  Fly   256 --SDERRHSTEILS-SVGKENTSPTTPVSATTTPGKKTSS-SNSSSAGGRTLEQRPTNEPATPTS 316
              |:|....:|:.: :.|:|.......|.::..|..:|:| .......||.:|.....|.....|
Zfish   498 EPSEEAGLESEVETLNAGEEVPPEPEVVPSSVAPEVETASLMERQEEQGREVEVEEEEEEGLARS 562

  Fly   317 ------------------STTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNA 363
                              ...|||............|..:.....||.:...:.|.::.::....
Zfish   563 EELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYEVAETAEETHLTNEP 627

  Fly   364 QNGSTSGNGSGQAAQPQSASN-----------------------GWTQEDA--------ATTTSP 397
            :.         :|.:|:..:|                       |.:|||.        ..:...
Zfish   628 ER---------EAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDELIPSGDGESVDS 683

  Fly   398 STTTSPPRHSQSPPTPNISPPASVTPSANGNVH---------SPNANSTPAGSG------GGSRS 447
            .|..:........|..|.....:..||...::|         .||..:.....|      ..:|:
Zfish   684 ETFVTETESELGVPQVNGDQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNRT 748

  Fly   448 YTAATP-----GQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQ 507
            .|...|     .|...|.||..|.|:.:.|.:|.|.|                       ..:.:
Zfish   749 TTWQRPTGPPAPQGLTRSSSILQMEQLNRRYQSIRRT-----------------------MTSER 790

  Fly   508 AARPFLDLPPGYEMRTTQQ-----------GQ---------------VYFYHIPTGVSTWH-DPR 545
            :..|.::.||..|.....|           ||               ..|...|...|..| :|.
Zfish   791 SEEPRVEDPPADETDVLAQSISEYRRDGIIGQASSRSRLALLLQSPGAKFLSSPDFFSVLHSNPS 855

  Fly   546 IPRDF---------------DTQHL-----TLDAIG----------PLPSGWEQRKTASGRVYFV 580
            ..|.|               |.||.     ..|.:.          .||.|||.:...:|:.:||
Zfish   856 AYRMFTSNTCLKHMISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFV 920

  Fly   581 DHNNRTTQFTDPRL-------SGSILQMIRRGTVPPTSAANAG----TPAPP------------- 621
            |||.|.|.|.||||       ||.:............||...|    :|:||
Zfish   921 DHNCRATTFIDPRLPLQNSRSSGLLAHRQHLSRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQD 985

  Fly   622 ----------------------------------------------SATPATPSAAAA------- 633
                                                          .||..|..::.|
Zfish   986 LVPVAYNDKIVAFLRQPNIFEILQERQPELVRNHSLREKVQFIRNEGATGLTRLSSDADLVMLLS 1050

  Fly   634 ---------VPPQATPAS---NATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLR 686
                     |||.|...|   :|:|.:           .|..|:.   .|.....|:||...|||
Zfish  1051 LFEEEVMSYVPPNALLLSSYCHASPQS-----------SPGTPRA---NARAPAPYKRDFEAKLR 1101

  Fly   687 ALRTELQT----MQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGV 746
            ....:::|    ..|  |..:|.:.|:.:.|:::..||....||: |.||.|.|.|||||||.|.
Zfish  1102 NFYRKMETKGYGQGP--GKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGP 1164

  Fly   747 AREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDG 811
            :||:..|:|||:.||.||||:||.:|.||:||:|.|....:|..:|.|.||.||:|:.|.:.||.
Zfish  1165 SREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDA 1229

  Fly   812 GFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPG 876
            .||.||||.||..|..|.|:|.:|.:.|:||.||.:::|..:::.||:|....||.:...|||||
Zfish  1230 FFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDMLDLTFTVNEEVFGQITERELKPG 1294

  Fly   877 GASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSI 941
            |:.|.|:::||:||::..|.:|..||:.||..:|.:||.|::...|:..||.|||||||.|.:.|
Zfish  1295 GSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEI 1359

  Fly   942 DVNDWRNNTRLKHCTNETTQVL-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
            |::||||||..:...::...|: |||..||.:::|.|.||||||||:|.:|.:||.:|:||.
Zfish  1360 DLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN--- 1421

  Fly  1006 GPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            |||.|.:.....|  .:||:|||||||:|||||.::.:|.:|:..|||||..|.:|
Zfish  1422 GPRRFCVEKWGKV--TSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETSTFGLE 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	31/162 (19%)
		PRP40	155..>283	CDD:227435	37/162 (23%)
		WW	169..198	CDD:459800	4/31 (13%)
		WW	514..546	CDD:197736	11/58 (19%)
		WW	562..594	CDD:197736	16/31 (52%)
		HECTc	702..1058	CDD:238033	166/357 (46%)
hecw2a	XP_021334623.2	None